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High Prevalence of Hepatitis C Infection Among Patients Receiving Hemodialysis at an Urban Dialysis Center

  • Sumathi Sivapalasingam (a1), Sharp F. Malak (a2), John F. Sullivan (a1), Jonathan Lorch (a1) and Kent A. Sepkowitz (a1) (a2)...
<span class='bold'>Objective:</span>

To determine the seroprevalence and risk factors for hepatitis C virus (HCV) infection among patients at an urban outpatient hemodialysis center.

<span class='bold'>Methods:</span>

This was a cross-sectional study of 227 patients undergoing hemodialysis at the Rogosin Kidney Center on December 15, 1998, with a response rate of 90% (227 of 253). Laboratory records were used to retrieve the total number of blood transfusions received and serologic study results. Univariate and multivariate analyses were used to examine the relationship among HCV serostatus, patient demographics, and HCV risk factors (eg, intravenous drug use [IVDU], intranasal cocaine use, multiple sexual partners, comorbidities, length of time receiving hemodialysis, and total number of blood transfusions received).

<span class='bold'>Results:</span>

The seroprevalence of antibody to HCV (anti-HCV) was 23.3% (53 of 227) in the population. In univariate analysis, factors associated with HCV seropositivity included male gender, younger age, history of IVDU, history of intranasal cocaine use, history of multiple sexual partners, human immunodeficiency virus coinfection, increased time receiving dialysis, history of renal transplant, and positive antibody to hepatitis B core antigen. Multivariate logistic regression analysis showed that longer duration receiving dialysis and a history of IVDU were the only risk factors that remained independently associated with HCV seropositivity.

<span class='bold'>Conclusions:</span>

HCV is markedly more common in our urban cohort of patients receiving hemodialysis compared with patients receiving dialysis nationally and is associated with a longer duration of receiving dialysis and a history of IVDU. Stricter and more frequent enforcement of universal precautions may be required in hemodialysis centers located in areas with a high prevalence of HCV infection or IVDU among the general population.

Corresponding author
Clinical Infectious Disease Section, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 288, New York, NY 10021
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2. MJ Alter , D Kruszon-Moran , OV Nainan , et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 1999;341:556562.

4. CO Stehman-Breen , S Emerson , D Gretch , RJ Johnson . Risk of death among chronic dialysis patients infected with hepatitis C virus. Am J Kidney Dis 1998,32:629634.

5. P Mathurin , C Mouquet , T Poyard , et al. Impact of hepatitis B and C virus on kidney transplantation outcome. Hepatology 1999;29:257263.

8. MT Niu , PJ Coleman , MJ Alter . Multicenter study of hepatitis C virus infection in chronic hemodialysis patients and hemodialysis center staff members. Am J Kidney Dis 1993;22:568573.

9. LJ Jeffers , GO Perez , MD de Medina , et al. Hepatitis C infection in two urban hemodialysis units. Kidney Int 1990;38:320322.

10. JP dos Santos , A Loureiro , M Cendoroglo , BJG Pereira . Impact of dialysis room and reuse strategies on the incidence of hepatitis C virus infection in hemodialysis units. Nephrol Dial Transplant 1996;11:20172022.

12. R Brugnano , D Francisci , G Quintaliani , et al. Antibodies against hepatitis C virus in hemodialysis patients in the central Italian region of Umbria: evaluation of some risk factors. Nephron 1992;61:263265.

13. JB Zeldis , TA Depner , IK Kuramoto , RG Gish , PV Holland . The prevalence of hepatitis C virus antibodies among hemodialysis patients. Ann Intern Med 1990;112:958960.

14. G Forseter , GP Wormser , S Adler , E Lebovics , M Calmann , TA O'Brien . Hepatitis C in the health care setting: II. Seroprevalence among hemodialysis staff and patients in suburban New York City. Am J Infect Control 1993;21:58.

15. A Mitwalli , S al-Mohaya , J al-Wakeel , et al. Hepatitis C in chronic renal failure patients. Am J Nephrol 1992;12:288291.

17. N Petrosillo , P Gilli , D Serraino , et al. Prevalence of infected patients and understaffing have a role in hepatitis C virus transmission in dialysis. Am J Kidney Dis 2001;37:10041010.

18. K Seme , M Poljak , S Zuzek-Resek , M Debeljak , P Dove , S Koren . Molecular evidence for nosocomial spread of two different hepatitis C virus strains in one hemodialysis unit. Nephron 1997;77:273278.

19. J Izopet , C Pasquier , K Sandres , J Puel , L Rostaing . Molecular evidence for nosocomial transmission of hepatitis C virus in a French hemodialysis unit. J Med Virol 1999;58:139144.

20. MJ Alter . Hepatitis C infection in the United States. J Hepatol 1999:31(suppl 1):8891.

21. C Conry-Cantilena , M Van Raden , J Gibble , et al. Routes of infection, viremia, and liver disease in blood donors found to have hepatitis C virus infection. N Engl J Med 1996;334:16911696.

22. BJ Pereira , EL Milford , RL Kirkman , AS Levey . Transmission of hepatitis C virus by organ transplantation. N Engl J Med 1991;325:454460.

23. BJG Pereira , EL Milford , RL Kirkman , et al. Prevalence of hepatitis C virus RNA in organ donors positive for hepatitis C antibody and in the recipients of their organs. N Engl J Med 1992;327:910915.

24. M Jadoul , C Cornu , C Van Ypersele De Strihou . Universal precautions prevent hepatitis C virus transmission: a 54 month follow-up of the Belgian Multicenter Study. Kidney Int 1998;53:10221025.

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Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
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