Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 10
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Gordon, Adrienne Greenhalgh, Mark McGuire, William and McGuire, William 2016. Cochrane Database of Systematic Reviews.


    Cantey, Joseph B. and Milstone, Aaron M. 2015. Bloodstream Infections. Clinics in Perinatology, Vol. 42, Issue. 1, p. 1.


    Hilde Verstraete, Evelien De Coen, Kris Vogelaers, Dirk and Blot, Stijn 2015. Risk Factors for Health Care–Associated Sepsis in Critically Ill Neonates Stratified by Birth Weight. The Pediatric Infectious Disease Journal, Vol. 34, Issue. 11, p. 1180.


    Balkhy, Hanan H. and Zingg, Walter 2014. Update on infection control challenges in special pediatric populations. Current Opinion in Infectious Diseases, Vol. 27, Issue. 4, p. 370.


    Keir, Amy Giesinger, Regan and Dunn, Michael 2014. How long should umbilical venous catheters remain in place in neonates who require long-term (≥5-7 days) central venous access?. Journal of Paediatrics and Child Health, Vol. 50, Issue. 8, p. 649.


    Verstraete, Evelien Boelens, Jerina Coen, Kris De Claeys, Geert Vogelaers, Dirk Vanhaesebrouck, Piet and Blot, Stijn 2014. Healthcare-Associated Bloodstream Infections in a Neonatal Intensive Care Unit over a 20-Year Period (1992–2011): Trends in Incidence, Pathogens, and Mortality. Infection Control & Hospital Epidemiology, Vol. 35, Issue. 05, p. 511.


    Lepainteur, Margaux Desroches, Marine Bourrel, Anne Sophie Aberrane, Said Fihman, Vincent L’Hériteau, François Razafimahefa, Hasini Derouin, Véronique Doucet-Populaire, Florence and Decousser, Jean-Winoc 2013. Role of the Central Venous Catheter in Bloodstream Infections Caused by Coagulase-negative Staphylococci in Very Preterm Neonates. The Pediatric Infectious Disease Journal, Vol. 32, Issue. 6, p. 622.


    Zingg, Walter Tomaske, Maren and Martin, Maria 2012. Risk of Parenteral Nutrition in Neonates—An Overview. Nutrients, Vol. 4, Issue. 12, p. 1490.


    Cho, Il Hyun Jung, Tae Woong Lee, Ju-young Moon, Se Na Bin, Joong Hyun Lee, Hyun Seung Lee, Jung-Hyun Kim, So Young and Sung, In Kyung 2011. Risk Factors of Catheter-related Bloodstream Infection Due to Methicillin-resistantStaphylococcus aureusin Very Low Birth Weight Infants. Journal of the Korean Society of Neonatology, Vol. 18, Issue. 2, p. 288.


    Lee, Jung Hyun 2011. Catheter-related bloodstream infections in neonatal intensive care units. Korean Journal of Pediatrics, Vol. 54, Issue. 9, p. 363.


    ×
  • Infection Control & Hospital Epidemiology, Volume 32, Issue 1
  • January 2011, pp. 42-49

Individualized Catheter Surveillance among Neonates: A Prospective, 8-Year, Single-Center Experience

  • Walter Zingg (a1), Klara M. Posfay-Barbe (a2), Riccardo E. Pfister (a2), Sylvie Touveneau (a1) and Didier Pittet (a1)
  • DOI: http://dx.doi.org/10.1086/657634
  • Published online: 02 January 2015
Abstract
Objective.

To monitor trends in central line-associated bloodstream infections and clinical sepsis (CLABICS) among neonates and to determine risk factors for infection, especially dwell time.

Design.

Prospective, single-center cohort study conducted from 2001 through 2008.

Setting.

University-affiliated tertiary care center.

Methods.

Individualized surveillance of catheter use and CLABICS episodes was conducted. Data were obtained via regular on-site visits made 3 times a week. Trends over time were estimated by Poisson regression, and risk factor analysis was conducted using a Cox proportional hazards model and logistic regression.

Results.

In all, 1,124 neonates were exposed to 2,210 central lines for a total of 12,746 catheter-days and 11,467 catheter-days at risk. The median duration of catheter use was 8 (interquartile range, 5–11) days for peripherally inserted central catheters (PICCs) and 4 (interquartile range, 2-6) days for umbilical catheters; 102 CLABICS episodes were detected. The median time to infection was 7 days. Incidence densities were 8.5 CLABICS episodes per 1,000 catheter-days at risk and 8.0 CLABICS episodes per 1,000 catheter-days. The highest rates were identified among neonates weighing 750 g or lower (14.9 CLABICS episodes per 1,000 catheter days at risk) and for PICCs (13.2 CLABICS episodes per 1,000 catheter days at risk). Catheter dwell time was associated with CLABICS for all umbilical catheters (odds ratio [OR], 1.2 per day of use [95% confidence interval {CI}, 1.1–1.3] P< .001) and for PICCs for up to 7 days (OR, 1.2 [95% CI, 1.1–1.4]; P = .041), but not thereafter (OR, 1.0 [95% CI, 0.9–1.1]; P = .90).

Conclusion.

Catheter dwell time is a risk factor for CLABICS during the first 7 days, irrespective of catheter type. After 7 days, PICCs are less likely to become infected.

Copyright
Corresponding author
University of Geneva Hospitals and Faculty of Medicine, 4 rue Gabrielle Perret-Gentil, 1211 Genève 14, Switzerland (didier.pittet@hcuge.ch)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.MT Brady . Health care-associated infections in the neonatal intensive care unit. Am J Infect Control 2005;33:268275.

3.BH Stover , ST Shulman , DF Bratcher , MT Brady , GL Levine , WR Jarvis . Nosocomial infection rates in US children's hospitals' neonatal and pediatric intensive care units. Am J Infect Control 2001;29:152157.

4.J Hentschel , B Brungger , K Studi , K Muhlemann . Prospective surveillance of nosocomial infections in a Swiss NICU: low risk of pneumonia on nasal continuous positive airway pressure? Infection 2005;33:350355.

5.F Schwab , C Geffers , S Barwolff , H Ruden , P Gastmeier . Reducing neo-natal nosocomial bloodstream infections through participation in a national surveillance system. J Hosp Infect 2007;65:319325.

7.H Sax , S Hugonnet , S Harbarth , P Herrault , D Pittet . Variation in nosocomial infection prevalence according to patient care setting: a hospital-wide survey. J Hosp Infect 2001;48:2732.

9.GA Contreras-Cuellar , AL Leal-Castro , R Prieto , AL Carvajal-Hermida . Device-associated infections in a Colombian neonatal intensive care unit. Rev Salud Publica (Bogota) 2007;9:439447.

10.AA El-Nawawy , MM Abd El-Fattah , HA Metwally , SS Barakat , IA Hassan . One year study of bacterial and fungal nosocomial infections among patients in pediatric intensive care unit (PICU) in Alexandria. J Trop Pediatr 2006;52:185191.

11.HH Balkhy , G Cunningham , FK Chew , et al. Hospital- and community-acquired infections: a point prevalence and risk factors survey in a tertiary care center in Saudi Arabia. Int J Infect Dis 2006;10:326333.

12.RC Couto , EA Carvalho , TM Pedrosa , ER Pedroso , MC Neto , FM Biscione . A 10-year prospective surveillance of nosocomial infections in neonatal intensive care units. Am J Infect Control 2007;35:183189.

14.UA Mireya , PO Marti , KV Xavier , LO Cristina , MM Miguel , CM Magda . Nosocomial infections in paediatric and neonatal intensive care units. J Infect 2007;54:212220.

16.SE Perlman , L Saiman , EL Larson . Risk factors for late-onset health care-associated bloodstream infections in patients in neonatal intensive care units. Am J Infect Control 2007;35:177182.

17.KM Posfay-Barbe , DM Zerr , D Pittet . Infection control in paediatrics. Lancet Infect Dis 2008;8:1931.

18.W Zingg , KM Posfay-Barbe , D Pittet . Healthcare-associated infections in neonates. Curr Opin Infect Dis 2008;21:228234.

19.CL Pessoa-Silva , S Hugonnet , R Pfister , et al. Reduction of health care associated infection risk in neonates by successful hand hygiene promotion. Pediatrics 2007;120:e382e390.

20.International Neonatal Network. The CRIB (clinical risk index for babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. Lancet 1993;342:193198.

21.V Apgar . A proposal for a new method of evaluation of the newborn infant. Curr Res Anesth Analg 1953;32:260267.

22.P Eggimann , S Harbarth , MN Constantin , S Touveneau , JC Chevrolet , D Pittet . Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care. Lancet 2000;355: 18641868.

23.TG Connell , M Rele , D Cowley , JP Buttery , N Curtis . How reliable is a negative blood culture result? volume of blood submitted for culture in routine practice in a children's hospital. Pediatrics 2007;119:891896.

24.S Hugonnet , H Sax , P Eggimann , JC Chevrolet , D Pittet . Nosocomial bloodstream infection and clinical sepsis. Emerg Infect Dis 2004;10:7681.

25.JS Garner , WR Jarvis , TG Emori , TC Horan , JM Hughes . CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988;16:128140.

26.TC Horan , M Andrus , MA Dudeck . CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008;36:309332.

27.P Eggimann , S Hugonnet , H Sax , S Touveneau , JC Chevrolet , D Pittet . Ventilator-associated pneumonia: caveats for benchmarking. Intensive Care Med 2003;29:20862089.

28.W Zingg , A Imhof , M Maggiorini , R Stacker , E Keller , C Ruef . Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections. Crit Care Med 2009; 37:21672173.

29.W Zingg , H Sax , C Inan , et al. Hospital-wide surveillance of catheter-related bloodstream infection: from the expected to the unexpected. J Hosp Infect 2009;73:4146.

30.J Freeman , DA Goldmann , NE Smith , DG Sidebottom , MF Epstein , R Piatt . Association of intravenous lipid emulsion and coagulase-negative staphylococcal bacteremia in neonatal intensive care units. N Engl J Med 1990;323:301308.

31.A Holmes , CJ Dore , A Saraswatula , et al. Risk factors and recommendations for rate stratification for surveillance of neonatal healthcare-associated bloodstream infection. J Hosp Infect 2008;68:6672.

32.E Nagata , AS Brito , T Matsuo . Nosocomial infections in a neonatal intensive care unit: incidence and risk factors. Am J Infect Control 2002; 30:2631.

33.MK Chathas , JB Paton , DE Fisher . Percutaneous central venous cathe-terization: three years' experience in a neonatal intensive care unit. Am J Dis Child 1990;144:12461250.

34.R Clark , R Powers , R White , B Bloom , P Sanchez , DK Benjamin Jr. Prevention and treatment of nosocomial sepsis in the NICU. J Perinatal 2004;24:446453.

35.BJ Stoll , N Hansen , AA Fanaroff , et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002;110:285291.

37.V Hoang , J Sills , M Chandler , E Busalani , R Clifton-Koeppel , HD Modanlou . Percutaneously inserted central catheter for total parenteral nutrition in neonates: complications rates related to upper versus lower extremity insertion. Pediatrics 2008; 121:e1152e1159.

38.N Ben Jaballah , A Bouziri , K Mnif , A Hamdi , A Khaldi , W Kchaou . Epidemiology of hospital-acquired bloodstream infections in a Tunisian pediatric intensive care unit: a 2-year prospective study. Am J Infect Control 2007;35:613618.

39.JR Edwards , KD Peterson , ML Andrus , MA Dudeck , DA Pollock , TC Horan . National Healthcare Safety Network (NHSN) report, data summary for 2006 through 2007, issued November 2008. Am J Infect Control 2008; 36:609626.

40.C Geffers , S Baerwolff , F Schwab , P Gastmeier . Incidence of healthcare-associated infections in high-risk neonates: results from the German surveillance system for very-low-birthweight infants. J Hosp Infect 2008; 68:214221.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×