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Lack of Evidence for Attributing Chlorhexidine as the Main Active Ingredient in Skin Antiseptics Preventing Surgical Site Infections

Published online by Cambridge University Press:  02 January 2015

Matthias Maiwald*
Affiliation:
. Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore
Andreas F. Widmer
Affiliation:
Division of Infectious Diseases and Hospital Epidemiology, University of Basel Hospitals, Basel, Switzerland
Manfred L. Rotter
Affiliation:
Institute of Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria
*Corresponding
Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore (matthias.maiwald@kkh.com.sg)
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Abstract

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Type
Letters to the Editor
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2011

References

1. Noorani, A, Rabey, N, Walsh, SR, Davies, RJ. Systematic review and meta-analysis of preoperative antisepsis with Chlorhexidine versus povidone-iodine in clean-contaminated surgery. Br J Surg 2010;97:16141620.CrossRefGoogle ScholarPubMed
2. Lee, I, Agarwal, RK, Lee, BY, Fishman, NO, Umscheid, CA. Systematic review and cost analysis comparing use of Chlorhexidine with use of iodine for preoperative skin antisepsis to prevent surgical site infection. Infect Control Hosp Epidemiol 2010;31:12191229.CrossRefGoogle ScholarPubMed
3. Gröschel, DHM, Pruett, TL. Surgical antisepsis. In: Block, SS, ed. Disinfection, Sterilization and Preservation. 4th ed. Philadelphia: Lea & Febiger, 1991:642654.Google Scholar
4. Rotter, ML. Hand washing, hand disinfection, and skin disinfection. In: Wenzel, RP, ed. Prevention and Control of Nosocomial Infections. 3rd ed. Baltimore: Williams & Willems, 1997:691709.Google Scholar
5. Rotter, ML. Hand washing and hand disinfection. In: Mayhall, CG, ed. Hospital Epidemiology and Infection Control. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2004:17271746.Google Scholar
6. Mangram, AJ, Horan, TC, Pearson, ML, Silver, LC, Jarvis, WR, Hospital Infection Control Practices Advisory Committee. Guideline for prevention of surgical site infection, 1999. Infect Control Hosp Epidemiol 1999;20:250278.CrossRefGoogle ScholarPubMed
7. Maiwald, M, Widmer, AF, Rotter, ML. Chlorhexidine is not the main active ingredient in skin antiseptics that reduce blood culture contamination rates. Infect Control Hosp Epidemiol 2010;31:10951096.CrossRefGoogle Scholar
8. Darouiche, RO, Wall, MJ Jr, Itani, KM, et al. Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med 2010;362:1826.CrossRefGoogle ScholarPubMed
9. Kampf, G, Shaffer, M, Hunte, C. Insufficient neutralization in testing a chlorhexidine-containing ethanol-based hand rub can result in a false positive efficacy assessment. BMC Infect Dis 2005;5:48.CrossRefGoogle Scholar
10. Swenson, BR, Hedrick, TL, Metzger, R, Bonatti, H, Pruett, TL, Sawyer, RG. Effects of preoperative skin preparation on postoperative wound infection rates: a prospective study of 3 skin preparation protocols. Infect Control Hosp Epidemiol 2009;30:964971.CrossRefGoogle ScholarPubMed
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Lack of Evidence for Attributing Chlorhexidine as the Main Active Ingredient in Skin Antiseptics Preventing Surgical Site Infections
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