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Large Outbreak of Infection and Colonization with Gram-Negative Pathogens Carrying the Metallo-β-Lactamase Gene bla IMP-4 at a 320-Bed Tertiary Hospital in Australia

  • Sophie Herbert (a1), Dag S. Halvorsen (a1), Tim Leong (a2), Clare Franklin (a1), Glenys Harrington (a3) and Denis Spelman (a1)...


A large outbreak of infection and colonization with multiple genera of gram-negative bacilli carrying the metallo-β-lactamase gene bla IMP-4 occurred in a 36-bed intensive care unit at a tertiary hospital in Australia. The organisms emerged rapidly, caused severe infections, and contributed to mortality. Controlling the spread of these organisms remains a challenge for all staff involved.


Corresponding author

Infectious Diseases and Microbiology Department, The Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia, (


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