Skip to main content Accessibility help

The Limits of Serial Surveillance Cultures in Predicting Clearance of Colonization with Carbapenemase-Producing Enterobacteriaceae

  • Jessica D. Lewis (a1), Kyle B. Enfield (a2) (a3), Amy J. Mathers (a1) (a4), Eve T. Giannetta (a3) and Costi D. Sifri (a1) (a3)...


An accepted practice for patients colonized with multidrug-resistant organisms is to discontinue contact precautions following 3 consecutive negative surveillance cultures. Our experience with surveillance cultures to detect persistent carbapenemase-producing Enterobacteriaceae (CPE) colonization suggests that extrapolation of this practice to CPE-colonized patients may not be appropriate.

Infect Control Hosp Epidemiol 2015;36(7):835–837


Corresponding author

Address all correspondence to Costi D. Sifri, MD, Division of Infectious Diseases & International Health, Office of Hospital Epidemiology/Infection Prevention & Control, University of Virginia Health System, P.O. Box 800473, Charlottesville, VA 22908-0473 (


Hide All
1. Nordmann, P, Naas, T, Poirel, L. Global spread of carbapenemase-producing Enterobacteriaceae . Emerg Infect Dis 2011;17:17911798.
2. Guidance for Control of Carbapenem-resistant Enterobacteriaceae (CRE)—2012 CRE Toolkit. Centers for Disease Control and Prevention website. Published 2013. Accessed July 25, 2013.
3. Centers for Disease Control and Prevention. Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. Morbid Mortal Weekly Rept 2009;58:256260.
4. Mathers, AJ, Carroll, J, Sifri, CD, Hazen, KC. Modified Hodge test versus indirect carbapenemase test: prospective evaluation of a phenotypic assay for detection of Klebsiella pneumoniae carbapenemase (KPC). in Enterobacteriaceae. J Clin Microbiol 2013;51:12911293.
5. Mathers, AJ, Hazen, KC, Carroll, J, et al. First clinical cases of OXA-48-producing carbapenem-resistant Klebsiella pneumoniae in the United States: the “menace” arrives in the new world. J Clin Microbiol 2013;51:680683.
6. Siegel, JD, Rhinehart, E, Jackson, M, Chiarello, L, the Healthcare Infection Control Practices Advisory Committee. Management of multidrug-resistant organisms in healthcare settings, 2006. Centers for Disease Control and Prevention website. Published 2006. Accessed October 31, 2014.
7. Byers, KE, Anglim, AM, Anneski, CJ, Farr, BM. Duration of colonization with vancomycin-resistant Enterococcus . Infect Control Hosp Epidemiol 2002;23:207211.
8. Feldman, N, Adler, A, Molshatzki, N, et al. Gastrointestinal colonization by KPC-producing Klebsiella pneumoniae following hospital discharge: duration of carriage and risk factors for persistent carriage. Clin Microbiol Infect 2013;19:E190E196.
9. Oren, I, Sprecher, H, Finkelstein, R, et al. Eradication of carbapenem-resistant Enterobacteriaceae gastrointestinal colonization with nonabsorbable oral antibiotic treatment: a prospective controlled trial. Am J Infect Control 2013;41:11671172.
10. Mathers, AJ, Cox, HL, Kitchel, B, et al. Molecular dissection of an outbreak of carbapenem-resistant Enterobacteriaceae reveals intergenus KPC carbapenemase transmission through a promiscuous plasmid. MBio 2011;2:e00204e00211.


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed