1. Dubberke, ER, Olsen, MA. Burden of Clostridium difficile on the healthcare system. Clin Infect Dis 2012;55(Suppl 2):S88–S92.
2. Freeman, J, Bauer, MP, Baines, SD, et al. The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev 2010;23:529–549.
3. Dubberke, ER, Butler, AM, Reske, KA, et al. Attributable outcomes of endemic Clostridium difficile-associated disease in nonsurgical patients. Emerg Infect Dis 2008;14:1031–1038.
4. Johnson, S. Recurrent Clostridium difficile infection: a review of risk factors, treatments, and outcomes. J Infect 2009;58:403–410.
5. Lessa, FC, Mu, Y, Bamberg, WM, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med 2015;372:825–834.
6. Slimings, C, Riley, TV. Antibiotics and hospital-acquired Clostridium difficile infection: update of systematic review and meta-analysis. J Antimicrob Chemother 2014;69:881–891.
7. Bauer, MP, Notermans, DW, Van Benthem, BH, et al.
Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011;377(9759):63–73.
8. Lessa, FC, Gould, CV, McDonald, LC. Current status of Clostridium difficile infection epidemiology. Clin Infect Dis 2012;55(Suppl 2):S65–S70.
9. Louie, TJ, Miller, MA, Crook, DW, et al. Effect of age on treatment outcomes in Clostridium difficile infection. J Am Geriatr Soc 2013;61:222–230.
10. Vesteinsdottir, I, Gudlaugsdottir, S, Einarsdottir, R, Kalaitzakis, E, Sigurdardottir, O, Bjornsson, ES. Risk factors for Clostridium difficile toxin-positive diarrhea: a population-based prospective case-control study. Eur J Clin Microbiol Infect Dis 2012;31:2601–2610.
11. Hill, C, Guarner, F, Reid, G, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11:506–514.
12. Goldenberg, JZ, Ma, SS, Saxton, JD, et al. Probiotics for the prevention of Clostridium difficile associated diarrhea in adults and children. Cochrane Database Syst Rev 2013;5:CD006095. doi: 10.1002/14651858.CD006095.pub3.
13. Goldenberg, JZ, Yap, C, Lytvyn, L, Lo, CK, Beardsley, J, Mertz, D, Johnston, BC. Probiotics for the prevention of Clostridium difficile associated diarrhea in adults and children. Cochrane Database Syst Rev 2017:12:CD006095.
14. Lytvyn, L, Mertz, D, Sadeghirad, B, Alaklobi, F, Selva, A, Alonso-Coello, P, Johnston, BC. Prevention of Clostridium difficile infection: a systematic survey of clinical practice guidelines. Infect Control Hosp Epidemiol 2016;37:901–908.
16. Dubberke, ER, Carling, P, Carrico, R, et al. Strategies to prevent Clostridium difficile infections in acute-care hospitals: 2014 update. Infect Control Hosp Epidemiol 2014;35:628–645.
17. Surawicz, CM, Brandt, LJ, Binion, DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013;108:478–498.
18. Vonberg, RP, Kuijper, E, Wilcox, M, et al. Infection control measures to limit the spread of Clostridium difficile
. Clin Microbiol Infect 2008;14(s5):2–20.
19. Hawkey, P, Bain, L, Borriello, P, et al. Clostridium difficile infection: how to deal with the problem. London: Public Health England and Department of Health; 2008.
20. Debast, S, Bauer, M, Kuijper, E. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin Microbiol Infect 2014;20(s2):1–26.
21. Lytvyn, L, Mertz, D, Thabane, L, et al. Probiotics for the prevention of Clostridium difficile infection in adults and children: an individual patient data meta-analysis. PROSPERO: International prospective register of systematic reviews. Master’s thesis, McMaster University. 2015. doi: 10.15124/CRD42015015701.
22. Bartlett, JG, Gerding, DN. Clinical recognition and diagnosis of Clostridium difficile Infection. Clin Infect Dis 2008;46(Suppl 1):S12–S18.
23. Higgins, J, Altman, DG, Gøtzsche, PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011:343.
24. Guyatt, GH, Oxman, AD, Vist, GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336(7650):924–926.
25. Egger, M, Smith, GD, Schneider, M, Minder, C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629–634.
26. Deeks, JJ, Higgins, J, Altman, DG. Analysing data and undertaking meta‐analyses. In: The Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series. Chichester, UK: Wiley & Sons; 2008. Pp. 243–296.
27. Johnston, BC, Goldenberg, JZ, Vandvik, PO, Sun, X, Guyatt, GH. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 2011;9(11).
28. Gerding, DN, Olson, MM, Peterson, LR, et al.
Clostridium difficile—associated diarrhea and colitis in adults: a prospective case-controlled epidemiologic study. Arch Intern Med 1986;146:95–100.
29. Gao, XW, Mubasher, M, Fang, CY, Reifer, C, Miller, LE. Dose–response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients. Am J Gastroenterol 2010;105:1636–1641.
30. Duman, DG, Bor, S, Özütemiz, Ö, et al. Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacter pylori eradication. Eur J Gastroenterol Hepatol 2005;17:1357–1361.
31. Bravo, MV, Bunout, D, Leiva, L, et al. Effect of probiotic Saccharomyces boulardii on prevention of antibiotic-associated diarrhea in adult outpatients with amoxicillin treatment. [In Spanish.] Revista Medica de Chile 2008;136:981–988.
32. Kotowska, M, Albrecht, P, Szajewska, H.
Saccharomyces boulardii in the prevention of antibiotic‐associated diarrhoea in children: a randomized double‐blind placebo‐controlled trial. Aliment Pharmacol Ther 2005;21:583–590.
33. Pozzoni, P, Riva, A, Bellatorre, AG, et al.
Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: a single-center, randomized, double-blind, placebo-controlled trial. Am J Gastroenterol 2012;107:922–931.
34. Hickson, M, D’Souza, AL, Muthu, N, et al. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo-controlled trial. BMJ 2007;335(7610):80.
35. Klarin, B, Wullt, M, Palmquist, I, Molin, G, Larsson, A, Jeppsson, B.
Lactobacillus plantarum 299v reduces colonisation of Clostridium difficile in critically ill patients treated with antibiotics. Acta Anaesthesiol Scand 2008;52:1096–1102.
36. Miller, M. Results of 2 prospective randomized studies of Lactobacillus GG to prevent C. difficile infection in hospitalized adults receiving antibiotics; 2008a.
37. Miller, M. Results of 2 prospective randomized studies of Lactobacillus GG to prevent C. difficile infection in hospitalized adults receiving antibiotics; 2008b.
38. Plummer, S, Weaver, MA, Harris, JC, Dee, P, Hunter, J.
Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. Int Microbiol 2010;7:59–62.
39. Psaradellis, E, Sampalis, J, Rampakakis, E. Efficacy of BIO K+ CL1285® in the reduction of antibiotic associated diarrhea–a placebo controlled double-blind randomized, multi-center study. Arch Med Sci 2010;6:56–64.
40. Selinger, C, Bell, A, Cairns, A, Lockett, M, Sebastian, S, Haslam, N. Probiotic VSL# 3 prevents antibiotic-associated diarrhoea in a double-blind, randomized, placebo-controlled clinical trial. J Hosp Infect 2013;84:159–165.
41. Allen, SJ, Wareham, K, Wang, D, et al. Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 2013;382(9900):1249–1257.
42. Wong, S, Jamous, A, O’Driscoll, J, et al. A Lactobacillus casei Shirota probiotic drink reduces antibiotic-associated diarrhoea in patients with spinal cord injuries: a randomised controlled trial. Brit J Nutr 2013;111:672–678.
43. Georgieva, M, Pancheva, R, Rasheva, N, Usheva, N, Ivanova, L, Koleva, K. Use of the probiotic Lactobacillus reuteri DSM 17938 in the prevention of antibiotic-associated infections in hospitalized Bulgarian children: a randomized controlled trial. J IMAB Annual Proceeding (Scientific Papers) 2015;21(4):895–900.
44. Ehrhardt, S, Guo, N, Hinz, R, et al.
Saccharomyces boulardii to prevent antibiotic-associated diarrhea: randomized, double-masked, placebo-controlled trial. Open Forum Infect Dis 2016;3(1):ofw011.
45. Lönnermark, E, Friman, V, Lappas, G, Sandberg, T, Berggren, A, Adlerberth, I. Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics. J Clin Gastroenterol 2010;44:106–112.
46. Ruszczyński, M, Radzikowski, A, Szajewska, H. Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic‐associated diarrhoea in children. Aliment Pharmacol Ther 2008;28:154–161.
47. Hempel, S, Newberry, S, Ruelaz, A, et al. Safety of probiotics to reduce risk and prevent or treat disease. Evid Rep Technol Assess (Full Rep). 2011:1–645.
48. Colli, A, Pozzoni, P, Conte, D, Casazza, G. Response to Kolber et al. Am J Gastroenterol 2014;109:1082–1083.
49. Brown, KA, Fisman, DN, Moineddin, R, Daneman, N. The magnitude and duration of Clostridium difficile infection risk associated with antibiotic therapy: a hospital cohort study. PLoS One 2014;9:e105454.
50. Szajewska, H. Pooling data on different probiotics is not appropriate to assess the efficacy of probiotics. Eur J Pediatr 2014;173:975.
51. Zawistowska-Rojek, A, Zareba, T, Mrówka, A, Tyski, S. Assessment of the microbiological status of probiotic products. Pol J Microbiol 2016;65:97–104.
52. Thomas, D, Radji, S, Benedetti, A. Systematic review of methods for individual patient data meta-analysis with binary outcomes. BMC Med Res Method 2014;14:79.
53. Brown, K, Valenta, K, Fisman, D, Simor, A, Daneman, N. Hospital ward antibiotic prescribing and the risks of Clostridium difficile infection. JAMA Intern Med 2015;175:626–633.