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A Novel, Sporicidal Formulation of Ethanol for Glove Decontamination to Prevent Clostridium difficile Hand Contamination During Glove Removal

  • Myreen E. Tomas (a1), Michelle M. Nerandzic (a2), Jennifer L. Cadnum (a3), Thriveen S. C. Mana (a3), Annette Jencson (a2), Venkata Sunskesula (a3), Sirisha Kundrapu (a3), Brigid M. Wilson (a1) and Curtis J. Donskey (a1) (a4)...

Abstract

Decontamination of gloves before removal could reduce the risk for contamination of hands of personnel caring for patients with Clostridium difficile infection. We demonstrated that a novel sporicidal formulation of ethanol rapidly reduced C. difficile spores on gloved hands without adverse odor, respiratory irritation, or staining of clothing.

Infect. Control Hosp. Epidemiol. 2016;37(3):337–339

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Copyright

Corresponding author

Address correspondence to Curtis J. Donskey, MD, Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, Ohio 44106 (curtisd123@yahoo.com).

References

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1. Kundrapu, S, Sunkesula, V, Jury, LA, Sitzlar, BM, Donskey, CJ. Daily disinfection of high-touch surfaces in isolation rooms to reduce contamination of healthcare workers’ hands. Infect Control Hosp Epidemiol 2012;33:10391042.
2. Landelle, C, Verachten, M, Legrand, P, Girou, E, Barbut, F, Brun-Buisson, C. Contamination of healthcare workers’ hands with Clostridium difficile spores after caring for patients with C. difficile infection. Infect Control Hosp Epidemiol 2014;35:1015.
3. Arfons, L, Ray, AJ, Donskey, CJ. Clostridium difficile infection among healthcare workers receiving antibiotic therapy. Clin Infect Dis 2005;40:13841385.
4. Hayden, MK, Blom, DW, Lyle, EA, Moore, CG, Weinstein, RA. Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant Enterococcus or the colonized patients’ environment. Infect Control Hosp Epidemiol 2008;29:149154.
5. Morgan, DJ, Liang, SY, Smith, CL, et al. Frequent multidrug-resistant Acinetobacter baumannii contamination of gloves, gowns, and hands of healthcare workers. Infect Control Hosp Epidemiol 2010;31:716721.
6. Kundrapu, S, Sunkesula, V, Jury, I, Deshpande, A, Donskey, CJ. A randomized trial of soap and water hand wash versus alcohol hand rub for removal of Clostridium difficile spores from hands of patients. Infect Control Hosp Epidemiol 2014;35:204206.
7. Tomas, ME, Kundrapu, S, Thota, P, et al. Contamination of the skin and clothing of healthcare personnel during removal of personal protective equipment [published online October 12, 2015]. JAMA Intern Med 2015.
8. Tomas, ME, Sunkesula, VCK, Kundrapu, S, Wilson, BM, Donskey, CJ. An intervention to reduce healthcare personnel hand contamination during care of patients with Clostridium difficile infection. Am J Infect Control. In press.
9. Nerandzic, MM, Sunkesula, VCK, Sankar, T, Setlow, P, Donskey, CJ. Unlocking the sporicidal potential of ethanol: induced sporicidal activity of ethanol against Clostridium difficile and Bacillus spores under altered physical and chemical conditions. PLOS ONE 2015;10:e0132805.
10. Nerandzic, MM, Sankar, T, Setlow, P, Donskey, CJ. A cumulative spore killing approach: synergistic sporicidal activity of dilute peracetic acid and ethanol at low pH against Clostridium difficile and Bacillus subtilis spores. Open Forum Infect Dis. In press.

A Novel, Sporicidal Formulation of Ethanol for Glove Decontamination to Prevent Clostridium difficile Hand Contamination During Glove Removal

  • Myreen E. Tomas (a1), Michelle M. Nerandzic (a2), Jennifer L. Cadnum (a3), Thriveen S. C. Mana (a3), Annette Jencson (a2), Venkata Sunskesula (a3), Sirisha Kundrapu (a3), Brigid M. Wilson (a1) and Curtis J. Donskey (a1) (a4)...

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