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Prevalence of Nasal Colonization Among Patients With Community-Associated Methicillin-Resistant Staphylococcus aureus Infection and Their Household Contacts

Published online by Cambridge University Press:  02 January 2015

Uzma Zafar ,
Leonard B. Johnson ,
Michel Hanna ,
Kathleen Riederer ,
Mamta Sharma ,
Mohamad G. Fakih ,
Muthayipalayam C. Thirumoorthi ,
Rand Farjo  and
Riad Khatib
Uzma Zafar
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan
Leonard B. Johnson*
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
Michel Hanna
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan
Kathleen Riederer
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan
Mamta Sharma
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
Mohamad G. Fakih
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
Muthayipalayam C. Thirumoorthi
Affiliation:
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
Rand Farjo
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan
Riad Khatib
Affiliation:
Department of Internal Medicine, St. John Hospital and Medical Center, Detroit, Michigan Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
*
19251 Mack Avenue, Suite 340, Grosse Pointe Woods, MI 48236 (leonard.johnson@stjohn.org)
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Abstract

Objective.

To evaluate the prevalence of colonization among patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection and their household contacts.

Design.

Prospective, observational laboratory study of nasal colonization among patients and their household members from September 15, 2004, to February 20, 2006.

Setting.

A 600-bed, urban, academic medical center.

Patients.

Fifty-one patients who presented with CA-MRSA infections and 49 household members had cultures of nasal swab specimens performed.

Results.

Skin and soft-tissue infections were seen in 50 patients (98%) and 2 household members. Twenty-one (41%) of 51 patients and 10 (20%) of 49 household members were colonized with MRSA. An additional 5 patients (10%) and 12 household members (24%) were colonized with methicillin-susceptible Staphylococcus aureus. Most MRSA isolates (95%; infective and colonizing) carried the staphylococcal cassette chromosome mec type IV complex, and 67% represented a single clone, identical to USA 300. Of the colonized household members, 5 had isolates related to the patients' infective isolate.

Conclusions.

The frequency of CA-MRSA colonization among household members of patients with CA-MRSA infections is higher than rates reported among the general population. Among colonized household members, only half of the MRSA strains were related to the patients' infective isolate. Within the same household, multiple strains of CA-MRSA may be present.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 28 , Issue 8 , August 2007 , pp. 966 - 969
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2007

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