Skip to main content
    • Aa
    • Aa

Severity of Clostridium difficile–Associated Disease (CDAD) in Allogeneic Stem Cell Transplant Recipients: Evaluation of a CDAD Severity Grading System

  • Erik R. Dubberke (a1), Justin Sadhu (a1), Robert Gatti (a2), Kimberly A. Reske (a1), John F. DiPersio (a3), Steven M. Devine (a3) and Victoria J. Fraser (a1)...

The purpose of this study was to develop and test a Clostridium difficile-associated disease (CDAD) grading system based on presenting symptoms in allogeneic stem cell transplant recipients. Patients with severe CDAD had significantly shorter median survival times and more adverse outcomes than patients with mild or moderate CDAD.

Corresponding author
Division of Infectious Diseases, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Avenue, St. Louis, MO 63110 (
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. S Johnson , DN Gerding . Clostridium difficile-associated diarrhea. Clin Infect Dis 1998;26:10271034.

2. J Altclas , A Requejo , G Jaimovich , V Milovic , L Feldman . Clostridium difficile infection in patients with neutropenia. Clin Infect Dis 2002;34:723.

3. R Avery , B Pohlman , K Adal , et al. High prevalence of diarrhea but infrequency of documented Clostridium difficile in autologous peripheral blood progenitor cell transplant recipients. Bone Marrow Transplant 2000;25:6769.

4. S Bilgrami , JM Feingold , D Dorsky , et al. Incidence and outcome of Clostridium difficile infection following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 1999;23:10391042.

5. E Blot , MC Escande , D Besson , et al. Outbreak of Clostridium difficile-related diarrhoea in an adult oncology unit: risk factors and microbiological characteristics. J Hosp Infect 2003;53:187192.

6. S Chakrabarti , A Lees , SG Jones , DW Milligan . Clostridium difficile infection in allogeneic stem cell transplant recipients is associated with severe graft-versus-host disease and non-relapse mortality. Bone Marrow Transplant 2000;26:871876.

7. M Gorschluter , A Glasmacher , C Hahn , et al. Clostridium difficile infection in patients with neutropenia. Clin Infect Dis 2001;33:786791.

9. M Tomblyn , L Gordon , S Singhai , et al. Rarity of toxigenic Clostridium difficile infections after hematopoietic stem cell transplantation: implications for symptomatic management of diarrhea. Bone Marrow Transplant 2002;30:517519.

10. MG van Kraaij , AW Dekker , LF Verdonck , et al. Infectious gastro-enteritis: an uncommon cause of diarrhoea in adult allogeneic and autologous stem cell transplant recipients. Bone Marrow Transplant 2000;26:299303.

11. S Ascioglu , JH Rex , B de Pauw , et al. Denning opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 2002;34:714.

14. L Kyne , C Merry , B O'Connell , et al. Factors associated with prolonged symptoms and severe disease due to Clostridium difficile. Age Ageing 1999;28:107113.

18. A Jacobs , K Barnard , R Fishel , JD Gradon . Extracolonic manifestations of Clostridium difficile infections: presentation of 2 cases and review of the literature. Medicine (Baltimore) 2001;80:88101.

19. SE Lowenkron , J Waxner , P Khullar , et al. Clostridium difficile infection as a cause of severe sepsis. Intensive Care Med 1996;22:990994.

20. W Chatila , CA Manthous . Clostridium difficile causing sepsis and an acute abdomen in critically ill patients. Crit Care Med 1995;23:11461150.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Infection Control & Hospital Epidemiology
  • ISSN: 0899-823X
  • EISSN: 1559-6834
  • URL: /core/journals/infection-control-and-hospital-epidemiology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Abstract views

Total abstract views: 30 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 24th May 2017. This data will be updated every 24 hours.