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Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure

  • Chanu Rhee (a1) (a2), Sarah R. Brown (a2), Travis M. Jones (a3), Cara O’Brien (a4), Anupam Pande (a5), Yasir Hamad (a5), Amy L. Bulger (a6), Kathleen A. Tobin (a7), Anthony F. Massaro (a2), Deverick J. Anderson (a3), David K. Warren (a5), Michael Klompas (a1) (a2) and for the CDC Prevention Epicenters Program (a1) (a2) (a3) (a4) (a5) (a6) (a7)...


We compared sepsis “time zero” and Centers for Medicare and Medicaid Services (CMS) SEP-1 pass rates among 3 abstractors in 3 hospitals. Abstractors agreed on time zero in 29 of 80 (36%) cases. Perceived pass rates ranged from 9 of 80 cases (11%) to 19 of 80 cases (23%). Variability in time zero and perceived pass rates limits the utility of SEP-1 for measuring quality.


Corresponding author

Author for correspondence: Chanu Rhee, MD, MPH, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston, MA 02215. E-mail:


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