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Ventilator Bundle Compliance and Risk of Ventilator-Associated Events

Published online by Cambridge University Press:  17 May 2018

Bryan D. Harris ,
Gale A. Thomas ,
Matthew H. Greene ,
Steven S. Spires  and
Thomas R. Talbot
Bryan D. Harris*
Affiliation:
Department of Medicine Vanderbilt University Medical Center, Nashville, Tennessee
Gale A. Thomas
Affiliation:
Department of Medicine Vanderbilt University Medical Center, Nashville, Tennessee
Matthew H. Greene
Affiliation:
Department of Medicine Vanderbilt University Medical Center, Nashville, Tennessee
Steven S. Spires
Affiliation:
Department of Medicine Vanderbilt University Medical Center, Nashville, Tennessee
Thomas R. Talbot
Affiliation:
Department of Medicine Vanderbilt University Medical Center, Nashville, Tennessee Department of Health Policy, Vanderbilt University MedicalCenter, Nashville, Tennessee
*
Address correspondence to Bryan D. Harris, MD, MPH, Vanderbilt University Medical Center, A-2200 MCN, 1161 21st Avenue South, Nashville, TN 37232 (bryan.d.harris@vanderbilt.edu).
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Abstract

OBJECTIVE

Ventilator bundles encompass practices that reduce the risk of ventilator complications, including ventilator-associated pneumonia. The impact of ventilator bundles on the risk of developing ventilator-associated events (VAEs) is unknown. We sought to determine whether decreased compliance to the ventilator bundle increases the risk for VAE development.

DESIGN

Nested case-control study.

SETTING

This study was conducted at 6 adult intensive care units at an academic tertiary-care center in Tennessee.

PATIENTS

In total, 273 patients with VAEs were randomly matched in a 1:4 ratio to controls by mechanical ventilation duration and ICU type.

METHODS

Controls were selected from the primary study population at risk for a VAE after being mechanically ventilated for the same number of days as a specified case. Using conditional logistic regression analysis, overall cumulative compliance, and compliance with individual components of the bundle in the 3 and 7 days prior to VAE development (or the control match day) were examined.

RESULTS

Overall bundle compliance at 3 days (odds ratio [OR], 1.15; P=.34) and 7 days prior to VAE diagnosis (OR, 0.96; P=.83) were not associated with VAE development. This finding did not change when limiting the outcome to infection-related ventilator-associated complications (IVACs) and after adjusting for age and gender. In the examination of compliance with specific bundle components increased compliance with chlorhexidine oral care was associated with increased risk of VAE development in all analyses.

CONCLUSIONS

Ventilator bundle compliance was not associated with a reduced risk for VAEs. Higher compliance with chlorhexidine oral care was associated with a greater risk for VAE development.

Infect Control Hosp Epidemiol 2018;39:637–643

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 39 , Issue 6 , June 2018 , pp. 637 - 643
Copyright
© 2018 by The Society for Healthcare Epidemiology of America. All rights reserved 

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Footnotes

PREVIOUS PRESENTATION. These data were presented in part at the Society for Healthcare Epidemiology of America Annual Meeting on May 19, 2016, in Atlanta, Georgia (abstract no. 8116).

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