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Bupropion in the treatment of depression in Parkinson's disease

  • Maria Załuska (a1) and Agnieszka Dyduch (a2)
  • DOI:
  • Published online: 01 September 2010

A 78-year-old female with a nine-year history of depression was hospitalized due to worsening depression and symptoms associated with Parkinson's disease (PD). Her motor abilities improved on levodopa and the depression improved after a trial of bupropion, following unsuccessful treatment with other antidepressants. We found four reports on successful treatment of depression in PD with bupropion. However, no controlled double-blind studies have been conducted so clinicians should be cautious when administering bupropion in depression in PD.

Corresponding author
Correspondence should be addressed to: Agnieszka Dyduch, Oddział Psychiatrii, Szpital Bielański, Cegłowska 80, 01-809 Warsaw, Poland. Phone: +48 601 178 946; Fax. +48 22 864 47 46. Email:
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J. Bailey and S. Waters (2008). Acute psychosis after bupropion treatment in a healthy 28-year-old woman. Journal of the American Board of Family Medicine, 21, 244245. doi: 10.3122/jabfm.2008.03.070236.

J. A. Brommelhoff , M. Gatz , B. Johansson , J. J. McArdle , L. Fratiglioni and N. L. Pedersen (2009). Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychology and Aging, 24, 373384. doi: 10.1037/a0015713.

S. Gebhardt , H. Röttgers , A. Bäcker , U. Schu and J. C. Krieg (2008). Treatment of panic disorder with bupropion in a patient with Parkinson's disease. Journal of Clinical Pharmacy and Therapeutics, 33, 575577. doi: 10.1111/j.1365-2710.2008.00952.x.

C. G. Goetz , C. M. Tanner and H. L. Klawans (1984). Bupropion in Parkinson's disease. Neurology, 34, 10921094.

F. Grandas and L. López-Manzanares (2007). Bupropion-induced parkinsonism. Movement Disorders, 22, 18301831. doi: 10.1002/mds.21425.

P. Remy , M. Doder , A. Lees , N. Turjanski and D. Brooks (2005). Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain, 128, 13141322. doi: 10.1093/brain/awh445.

M. Shiba (2000). Anxiety disorders and depressive disorders preceding Parkinson's disease: a case-control study. Movement Disorders, 15, 669677.

W. M. Stein and S. Read (1997). Chronic pain in the setting of Parkinson's disease and depression. Journal of Pain and Symptom Management, 14, 255258. doi: 10.1016/S0885-3924(97)00176-0.

C. Veazey , S. O. Aki , K. F. Cook , E. C. Lai and M. E. Kunik (2005). Prevalence and treatment of depression in Parkinson's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 17, 310323. doi: 10.1176/appi.neuropsych.17.3.310.

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International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
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