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Clarifying dementia risk factors: treading in murky waters

  • Halima Amjad (a1) and Esther S. Oh (a1)

In light of the growing burden of dementia, continued research into risk factors and potential contributors to disease development is essential. Clearly established risk factors can not only inform our understanding of disease pathophysiology and treatments but also identify potential preventive strategies. While age and the ApoE4 allele have consistently been shown to increase risk of developing dementia (Kukull et al., 2002), other risk factors have been less studied or have had inconsistent findings. The study by Booker and colleagues (Booker et al., 2016) re-examines proposed late-life medical risk factors for incident dementia in a large population-based case-control study. This important contribution is best interpreted in the context of existing research.

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A. Booker , L. EC Jacob , M. Rapp , J. Bohlken and K. Kostev (2016). Risk factors for dementia diagnosis in German primary care patients. International Psychogeriatrics. doi:10.1017/S1041610215002082.

A. L. Fitzpatrick et al. (2009). Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Archives of Neurology, 66, 336342.

B. Haenisch et al. (2015). Risk of dementia in elderly patients with the use of proton pump inhibitors. European Archives of Psychiatry and Clinical Neuroscience, 265, 419428.

J. Ilomaki , N. Jokanovic , E. CK Tan and E. Lonnroos (2015). Alcohol consumption, dementia and cognitive decline: an overview of systematic reviews. Current Clinical Pharmacology, 10, 204212.

L. H. Kuller (2016). Do proton pump inhibitors increase the risk of dementia? JAMA Neurology, 73, 379381. doi:10.1001/jamaneurol.2015.4931.

C. L. Satizabal et al. (2016). Incidence of dementia over three decades in the framingham heart study. New England Journal of Medicine, 374, 523532.

K. M. Sink et al. (2009). Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the cardiovascular health study. Archives of Internal Medicine, 169, 11951202.

S. Yasar et al. (2013). Antihypertensive drugs decrease risk of alzheimer disease: ginkgo evaluation of memory study. Neurology, 81, 896903. doi:10.1212/WNL.0b013e3182a35228.

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International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
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