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Clarifying dementia risk factors: treading in murky waters

  • Halima Amjad (a1) and Esther S. Oh (a1)
Extract

In light of the growing burden of dementia, continued research into risk factors and potential contributors to disease development is essential. Clearly established risk factors can not only inform our understanding of disease pathophysiology and treatments but also identify potential preventive strategies. While age and the ApoE4 allele have consistently been shown to increase risk of developing dementia (Kukull et al., 2002), other risk factors have been less studied or have had inconsistent findings. The study by Booker and colleagues (Booker et al., 2016) re-examines proposed late-life medical risk factors for incident dementia in a large population-based case-control study. This important contribution is best interpreted in the context of existing research.

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Corresponding author
Email: hamjad1@jhmi.edu
References
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Booker, A., EC Jacob, L., Rapp, M., Bohlken, J. and Kostev, K. (2016). Risk factors for dementia diagnosis in German primary care patients. International Psychogeriatrics. doi:10.1017/S1041610215002082.
Fitzpatrick, A. L. et al. (2009). Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Archives of Neurology, 66, 336342.
Gomm, W. et al. (2016). Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurology, 73, 410416. doi:10.1001/jamaneurol.2015.4791.
Haenisch, B. et al. (2015). Risk of dementia in elderly patients with the use of proton pump inhibitors. European Archives of Psychiatry and Clinical Neuroscience, 265, 419428.
Ilomaki, J., Jokanovic, N., CK Tan, E. and Lonnroos, E. (2015). Alcohol consumption, dementia and cognitive decline: an overview of systematic reviews. Current Clinical Pharmacology, 10, 204212.
Kukull, W. A. et al. (2002). Dementia and alzheimer disease incidence: a prospective cohort study. Archives of Neurology, 59, 17371746.
Kuller, L. H. (2016). Do proton pump inhibitors increase the risk of dementia? JAMA Neurology, 73, 379381. doi:10.1001/jamaneurol.2015.4931.
Li, G. et al. (2007). Age‐Varying association between blood pressure and risk of dementia in those aged 65 and older: a community‐based prospective cohort study. Journal of the American Geriatrics Society, 55, 11611167.
Mielke, M. M. et al. (2010). The 32-year relationship between cholesterol and dementia from midlife to late life. Neurology, 75, 18881895. doi:10.1212/WNL.0b013e3181feb2bf.
Muldoon, M. F., Ryan, C. M., Sereika, S. M., Flory, J. D. and Manuck, S. B. (2004). Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults. The American Journal of Medicine, 117, 823829.
Satizabal, C. L. et al. (2016). Incidence of dementia over three decades in the framingham heart study. New England Journal of Medicine, 374, 523532.
Sink, K. M. et al. (2009). Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the cardiovascular health study. Archives of Internal Medicine, 169, 11951202.
Song, Y., Nie, H., Xu, Y., Zhang, L. and Wu, Y. (2013). Association of statin use with risk of dementia: a meta‐analysis of prospective cohort studies. Geriatrics & Gerontology International, 13, 817824.
Yasar, S. et al. (2013). Antihypertensive drugs decrease risk of alzheimer disease: ginkgo evaluation of memory study. Neurology, 81, 896903. doi:10.1212/WNL.0b013e3182a35228.
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International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
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