Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 21
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Cammisuli, D.M. Danti, S. Bosinelli, F. and Cipriani, G. 2016. Non-pharmacological interventions for people with Alzheimer's Disease: A critical review of the scientific literature from the last ten years. European Geriatric Medicine, Vol. 7, Issue. 1, p. 57.

    Capotosto, Emanuela Belacchi, Carmen Gardini, Simona Faggian, Silvia Piras, Federica Mantoan, Vanessa Salvalaio, Elisa Pradelli, Samantha and Borella, Erika 2016. Cognitive stimulation therapy in the Italian context: its efficacy in cognitive and non-cognitive measures in older adults with dementia. International Journal of Geriatric Psychiatry,

    Ibarria, Marta Alegret, Montserrat Valero, Sergi Morera, Amèrica Guitart, Marina Cañabate, Pilar Moreno, Mariola Lara, Susana Diego, Susana Hernández, Joan Tantinyá, Natàlia Vera, Maribel Hernández, Isabel Becker, James T. Ruíz, Agustín Boada, Mercè and Tárraga, Lluís 2016. Beneficial Effects of an Integrated Psychostimulation Program in Patients with Alzheimer’s Disease. Journal of Alzheimer's Disease, Vol. 50, Issue. 2, p. 559.

    D'Onofrio, Grazia Sancarlo, Daniele Addante, Filomena Ciccone, Filomena Cascavilla, Leandro Paris, Francesco Elia, Anna Chiara Nuzzaci, Claudia Picoco, Michele Greco, Antonio Panza, Francesco and Pilotto, Alberto 2015. A pilot randomized controlled trial evaluating an integrated treatment of rivastigmine transdermal patch and cognitive stimulation in patients with Alzheimer's disease. International Journal of Geriatric Psychiatry, Vol. 30, Issue. 9, p. 965.

    Quintana-Hernández, Domingo J. Miró-Barrachina, María T. Ibáñez-Fernández, Ignacio J. Pino, Angelo Santana-del Quintana-Montesdeoca, María P. Rodríguez-de Vera, Bienvenida Morales-Casanova, David Pérez-Vieitez, María del Carmen Rodríguez-García, Javier and Bravo-Caraduje, Noelia 2015. Mindfulness in the Maintenance of Cognitive Capacities in Alzheimer’s Disease: A Randomized Clinical Trial. Journal of Alzheimer's Disease, Vol. 50, Issue. 1, p. 217.

    Yamanaka, Katsuo Kawano, Yoshiyuki Noguchi, Dai Nakaaki, Shutaro Watanabe, Norio Amano, Takashi and Spector, Aimee 2013. Effects of cognitive stimulation therapy Japanese version (CST-J) for people with dementia: a single-blind, controlled clinical trial. Aging & Mental Health, Vol. 17, Issue. 5, p. 579.

    Andersen, Fred Viitanen, Matti Halvorsen, Dag S Straume, Bjørn Wilsgaard, Tom and Engstad, Torgeir A 2012. The effect of stimulation therapy and donepezil on cognitive function in Alzheimer’s disease. A community based RCT with a two-by-two factorial design. BMC Neurology, Vol. 12, Issue. 1,

    Woods, Bob Aguirre, Elisa Spector, Aimee E Orrell, Martin and Woods, Bob 2012. Cochrane Database of Systematic Reviews.

    Coen, Robert F Flynn, Bronagh Rigney, Edel O'Connor, Elaine Fitzgerald, Liza Murray, Ciaran Dunleavy, Catherine McDonald, Mindy Delaney, Deirdre Merriman, Niamh and Edgeworth, Jennifer 2011. Efficacy of a cognitive stimulation therapy programme for people with dementia. Irish Journal of Psychological Medicine, Vol. 28, Issue. 03, p. 145.

    Hattori, Hideyuki Hattori, Chikako Hokao, Chieko Mizushima, Kumiko and Mase, Toru 2011. Controlled study on the cognitive and psychological effect of coloring and drawing in mild Alzheimer's disease patients. Geriatrics & Gerontology International, Vol. 11, Issue. 4, p. 431.

    Spector, Aimee Gardner, Charlotte and Orrell, Martin 2011. The impact of Cognitive Stimulation Therapy groups on people with dementia: Views from participants, their carers and group facilitators. Aging & Mental Health, Vol. 15, Issue. 8, p. 945.

    Yuill, Natasha and Hollis, Vivien 2011. A Systematic Review of Cognitive Stimulation Therapy for Older Adults with Mild to Moderate Dementia: An Occupational Therapy Perspective. Occupational Therapy International, Vol. 18, Issue. 4, p. 163.

    Aguirre, Elisa Spector, Aimee Hoe, Juanita Russell, Ian T Knapp, Martin Woods, Robert T and Orrell, Martin 2010. Maintenance Cognitive Stimulation Therapy (CST) for dementia: A single-blind, multi-centre, randomized controlled trial of Maintenance CST vs. CST for dementia. Trials, Vol. 11, Issue. 1,

    de Oliveira Assis, Luciana Tirado, Marcella Guimarães Assis de Melo Pertence, Antônio Eustáquio Pereira, Leani Souza Máximo and Mancini, Marisa Cotta 2010. Evaluation of cognitive technologies in geriatric rehabilitation: a case study pilot project. Occupational Therapy International, Vol. 17, Issue. 2, p. 53.

    de Sant’Anna, M. de Rotrou, J. Wu, Y.-H. Faucounau, V. Boulay, M. Cantegreil, I. Pino, M. Riguet, M. Seux, M.-L. Hugonot, L. Labourée, F. Orvoen, G. Moulin, F. Lenoir, H. Wenisch, E. Boespflug, S. and Rigaud, A.-S. 2010. L’informatisation : une nouvelle perspective de développement pour la stimulation cognitive ou l’entraînement cognitif. NPG Neurologie - Psychiatrie - Gériatrie, Vol. 10, Issue. 56, p. 65.

    MATSUDA, Osamu SHIDO, Emi HASHIKAI, Ayako SHIBUYA, Haruka KOUNO, Mitsue HARA, Chizuko and SAITO, Masahiko 2010. Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease. Psychogeriatrics, Vol. 10, Issue. 4, p. 167.

    Rigaud, A.-S. Simonnet, T. Rialle, V. Rumeau, P. Vallet, C. Baldinger, J.-L. Belfeki, I. Boudy, J. de Rotrou, J. de Sant’Anna, M. Extra, J. Faucounau, V. Labourée, F. Lacombe, A. Orvoen, G. Riguet, M. Vella, F. Vigourou, N. and Wu, Y.-H. 2010. Un exemple d’aide informatisée à domicile pour l’accompagnement de la maladie d’Alzheimer : le projet TANDEM. NPG Neurologie - Psychiatrie - Gériatrie, Vol. 10, Issue. 56, p. 71.

    Westphal, Alissa Dingjan, Phillip and Attoe, Robyn 2010. What can low and high technologies do for late-life mental disorders?. Current Opinion in Psychiatry, Vol. 23, Issue. 6, p. 510.

    Jalbert, J. J. Daiello, L. A. and Lapane, K. L. 2008. Dementia of the Alzheimer Type. Epidemiologic Reviews, Vol. 30, Issue. 1, p. 15.

    Spector, Aimee Woods, Bob and Orrell, Martin 2008. Cognitive stimulation for the treatment of Alzheimer’s disease. Expert Review of Neurotherapeutics, Vol. 8, Issue. 5, p. 751.


Cognitive stimulation therapy for Alzheimer's disease: the effect of cognitive stimulation therapy on the progression of mild Alzheimer's disease in patients treated with donepezil

  • Osamu Matsuda (a1)
  • DOI:
  • Published online: 01 September 2006

Background: There is general consensus regarding the benefit of acetylcholinesterase inhibitors (e.g. donepezil) in Alzheimer's disease (AD). However, the combined effect of acetylcholinesterase and cognitive stimulation therapy (CST) is still controversial.

Objective: This study examines their combined effect on the progression of cognitive decline in AD by comparing the cognitive performance of 17 AD patients treated with CST and donepezil (combined treatment group) and 13 AD patients treated with donepezil alone (control group).

Methods: Patients in the combined treatment group received 5 mg of donepezil per day and about 20 one-hour CST sessions for one year, whereas the control group received only 5 mg of donepezil per day. The first eight sessions were carried out once a week, and subsequent sessions were generally once every two weeks. The patients were evaluated for changes in cognitive ability by administering the Mini-mental State Examination (MMSE) before the start of CST (baseline) and about one year later (follow-up).

Results: A repeated-measure analysis of variance revealed a significant group × time interaction. The MMSE score decreased significantly in the control group, but did not change significantly in the combined treatment group. Three patients in the control group declined by four points on the MMSE, compared to none in the combined treatment group. Effect size (ES) in the control group was relatively large and negative, while the ES in the combined treatment group was close to zero.

Conclusions: The results suggest the possibility that donepezil plus CST slowed the rate of cognitive decline more than the administration of donepezil alone.

Corresponding author
Correspondence should be addressed to: Osamu Matsuda, Department of Clinical Psychology, Faculty of Educational Psychology, Tokyo Gakugei University 4-1-1 Nukuikita Machi, Koganei-shi, Tokyo 184-8501, Japan. Phone: +81 42 329 7373; Fax: +81 42 329 7373. Email:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *