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Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease

  • Barry Reisberg (a1) and Serge Gauthier (a2)
Abstract

At the present time, there is increasing recognition and understanding of the mild cognitive impairment (MCI) entity as a stage which is a frequent precursor and harbinger of subsequently manifest Alzheimer's disease (AD) and, perhaps, other related conditions, such as vascular dementia (Gauthier et al., 2006). MCI has been defined in two disparate but generally compatible ways in the current literature (see Reisberg et al., 2008 (this issue), for a more complete historical overview of MCI). These two definitional approaches might be termed: (a) the clinical approach to MCI, and (b) the clinical plus psychometric approach to MCI.

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Archer H. A. et al. 2006. Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of clinical cohort. International Journal of Geriatric Psychiatry, 21, 12061212.
Berg L. 1988. Clinical dementia rating (CDR). Psychopharmacology Bulletin, 24, 637639.
Blazer D. G.Hays J. C.Fillenbaum G. G. and Gold D. T. 1997. Memory complaint as a predictor of cognitive decline. Journal of Aging Health, 9, 171184.
Blessed G.Tomlinson B. E. and Roth M. 1968. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797811.
Bobinski M. et al. 1995. Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease. Dementia, 6, 205210.
Bobinski M. et al. 1997. Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease. Journal of Neuropathology and Experimental Neurology, 56, 414420.
Bolla K. I.Lindgren K. N.Bonaccorsy C. and Bleecker M. L. 1991. Memory complaints in older adults. Fact or fiction? Archives of Neurology, 48, 6164.
Bruscoli M. and Lovestone S. 2004. Is MCI really just early dementia? A systematic review of conversion studies. International Psychogeriatrics, 16, 129140.
Burton E. J.McKeith I. G.Burn D. J.Firbank M. J. and O'Brien J. T. 2006. Progression of white matter hyperintensities in Alzheimer disease, dementia with Lewy bodies, and Parkinson disease dementia: a comparison with normal aging. American Journal of Geriatric Psychiatry, 14, 842849.
Clarnette R. M.Almeida O. P.Förstl H.Paton A and Martins R. N. 2001. Clinical characteristics of individuals with subjective memory loss in Western Australia: results from a cross-sectional survey. International Journal of Geriatric Psychiatry, 16, 168174.
Czéh B. et al. 2001. Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proceedings of the National Academy of Sciences of the United States of America, 98, 12320–12322.
Feehan M.Knight R. G. and Partridge F. M. 1991. Cognitive complaint and test performance in elderly patients suffering depression or dementia. International Journal of Geriatric Psychiatry, 6, 287293.
Flicker C.Ferris S. H. and Reisberg B. 1991. Mild cognitive impairment in the elderly: predictors of dementia. Neurology, 41, 10061009.
Folstein M. F.Folstein S. E. and McHugh P. R. 1975.“Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Gagnon M. et al. 1994. Self-reported memory complaints and memory performance in elderly French community residents: results of the PAQUID Research Program. Neuroepidemiology, 13, 145154.
García-Verdugo J. M.Doetsch F.Wichterle H.Lim D. A. and Alvarez-Buylla A. 1998. Architecture and cell types of the adult subventricular zone: in search of the stem cells. Journal of Neurobiology, 36, 234248.
Gauthier S. et al. 2006. Mild Cognitive Impairment. Lancet, 367, 12621270. DOI: 10.1016/S0140-6736(06)68542-5.
Geerlings M. I.Jonker C.Bouter L. M.Adèr H. J. and Schmand B. 1999. Association between memory complaints and incident Alzheimer's disease in elderly people with normal baseline cognition. American Journal of Psychiatry, 156, 531537.
Gilbert J. G. and Levee R. F. 1971. Patterns of declining memory. Journal of Gerontology, 26, 7075.
Glodzik-Sobanska L. et al. 2007. Subjective memory complaints: presence, severity and future outcome in normal older subjects. Dementia and Geriatric Cognitive Disorders, 24, 177184.
Gould E.Tanapat P.McEwen B. S.Flügge G. and Fuchs E. 1998. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proceedings of the National Academy of Sciences of the United States of America, 95, 3168–3171.
Gurvits T. V. et al. 1996. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biological Psychiatry, 40, 10911099.
Hamilton M. 1960. A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23, 5662.
Heun R.Kölsch H. and Jessen F. 2006. Risk factors and early signs of Alzheimer's disease in a family study sample: risk of AD. European Archives of Psychiatry and Clinical Neuroscience, 256, 2836. DOI: 10.1007/s00406-005-0596-4.
Hughes C. P.Berg L.Danziger W. L.Coben L. A. and Martin R. L. 1982. A new clinical scale for the staging of dementia. British Journal of Psychiatry, 140, 566572.
Jonker C.Geerlings M. I. and Schmand B. 2000. Are memory complaints predictive for dementia? A review of clinical and population-based studies. International Journal of Geriatric Psychiatry, 15, 983991.
Jorm A. F.Christensen H.Korten A. E.Jacomb P. A. and Henderson A. S. 2001. Memory complaints as a precursor of memory impairment in older people: a longitudinal analysis over 7–8 years. Psychological Medicine, 31, 441449.
Kluger A.Ferris S. H.Golomb J.Mittelman M. S. and Reisberg B. 1999. Neuropsychological prediction of decline to dementia in nondemented elderly. Journal of Geriatric Psychiatry and Neurology, 12, 168179.
Lam L. C.Lui V. W.Tam C. W. and Chiu H. F. 2005. Subjective memory complaints in Chinese subjects with mild cognitive impairment and early Alzheimer's disease. International Journal of Geriatric Psychiatry, 20, 876882.
Lautenschlager N. T.Flicker L.Vasikaran S.Leedman P. and Almeida O. P. 2005. Subjective memory complaints with and without objective memory impairment: relationship with risk factors for dementia. American Journal of Geriatric Psychiatry, 13, 731734.
Lehman H. E. and Ban T. A. 1970. Psychometric tests in evaluation of brain pathology responsive to drugs. Geriatrics, 25, 142147.
McCarthy M.Ferris F. H.Clark E. and Crook T. 1981. Acquisition and retention of categorized material in normal aging and senile dementia. Experimental Aging Research, 7, 127135.
Minett T. S.Dean J. L.Firbank M.English P. and O'Brien J. T. 2005. Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients. American Journal of Geriatric Psychiatry, 13, 665671.
Morris J. C. 1993. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology, 43, 24122414.
Mosconi L. et al. 2007. Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E ε4 carriers with subjective memory complaints. Biological Psychiatry (e-published ahead of print). Doi: 10.1016/j.biopsych.2007.05.030.
O'Brien J. T. et al. 2006. White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study. American Journal of Geriatric Psychiatry, 14, 834841.
O'Connor D. W.Pollitt P. A.Roth M.Brook P. B. and Reiss B. B. 1990. Memory complaints and impairment in normal, depressed, and demented elderly persons identified in a community survey. Archives of General Psychiatry, 47, 224227.
Petersen R. C.Stevens J. C.Ganguli M.Tangalos E. G.Cummings J. L. and DeKosky S. T. 2001. Practice parameter – early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 11331142.
Petersen R. C. et al. 2005. Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine, 352, 23792388.
Plotkin D. A.Mintz J. and Jarvik L. F. 1985. Subjective memory complaints in geriatric depression. American Journal of Psychiatry, 142, 11031105.
Prichep L. S. et al. 1994 Quantitative EEG correlates of cognitive deterioration in the elderly. Neurobiology of Aging, 15, 8590.
Prichep L. S. et al. 2006. Prediction of longitudinal cognitive decline in normal elderly using electrophysiological imaging. Neurobiology of Aging, 27, 471481.
Reisberg B. 1986. Dementia: a systematic approach to identifying reversible causes. Geriatrics, 41, 3046.
Reisberg B.Ferris S. H.de Leon M. J. and Crook T. 1982. The Global Deterioration Scale for assessment of primary degenerative dementia. American Journal of Psychiatry, 139, 11361139.
Reisberg B.Gordon B.McCarthy M.Ferris S. H. and de Leon M. J. 1985. Insight and denial accompanying progressive cognitive decline in normal aging and Alzheimer's disease. In Stanley B. (ed.), Geriatric Psychiatry: Ethical and Legal Issues (pp. 3779), Washington, D.C: American Psychiatric Press.
Reisberg B. et al. 1988. Stage-specific behavioral, cognitive, and in vivo changes in community residing subjects with age-associated memory impairment and primary degenerative dementia of the Alzheimer type. Drug Development Research, 15, 101114.
Reisberg B.Ferris S. H.Kluger A.Franssen E.Weigel J. and de Leon M. J. 2008. Mild cognitive impairment (MCI): a historical perspective. International Psychogeriatrics, 20, 1831.
Rissman R. A.Lee K. F.Vale W. and Sawchenko P. E. 2007. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. Journal of Neuroscience, 27, 65526562. DOI:10.1523/JNEUROSCI.5173-06.2007.
Santarelli L. et al. 2003. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301, 805809.
Saykin A. J. et al. 2006. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology, 67, 834842.
Shah P. J.Ebmeier K. P.Glabus M. F. and Goodwin G. M. 1998. Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression. Controlled magnetic resonance imaging study. British Journal of Psychiatry, 172, 527532.
Sheline Y. I.Wang P. W.Gado M. H.Csernansky J. G. and Vannier M. W. 1996. Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences of the United States of America, 93, 3908–3913.
St John P. and Montgomery P. 2002. Are cognitively intact seniors with subjective memory loss more likely to develop dementia? International Journal of Geriatric Psychiatry, 17, 814820. DOI: 10.1002/gps.559.
Tobiansky R.Blizard R.Livingston G. and Mann A. 1995. The Gospel Oak Study stage IV: the clinical relevance of subjective memory impairment in older people. Psychological Medicine, 25, 779786.
van Oijen M.de Jong F.Hofman A.Koudstaal P. and Breteler M. 2007. Subjective memory complaints, education, and risk of Alzheimer's disease. Alzheimer's and Dementia, 3, 9297.
Van Der Flier W. M. et al. 2004. Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes. Journal of Neurology, 251, 671675.
Wang P. N. et al. 2000. Subjective memory complaint in relation to cognitive performance and depression: a longitudinal study of a rural Chinese population. Journal of the American Geriatrics Society, 48, 295–99.
Wechsler D. A. 1958. The Measurement and Appraisal of Adult Intelligence. Baltimore: Williams and Wilkins.
Wen Y. et al. 2007. CDK5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. Biochimica et Biophysica Acta, 1772, 473483.
Wolf O. T. et al. 2005. Subjective memory complaints in aging are associated with elevated cortisol levels. Neurobiology of Aging, 26, 13571363.
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International Psychogeriatrics
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