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Depression is more strongly associated with cognition in elderly women than men with type 2 diabetes

Published online by Cambridge University Press:  11 December 2018

Laili Soleimani Open the ORCID record for Laili Soleimani [Opens in a new window] ,
Ramit Ravona-Springer ,
Anthony Heymann ,
Elizabeth Guerrero-Berroa ,
James Schmeidler ,
Ruth Zukran ,
Rachel Preiss ,
Jeremy M. Silverman ,
Mary Sano  and
Michal Schnaider Beeri
Laili Soleimani*
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Ramit Ravona-Springer
Affiliation:
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Anthony Heymann
Affiliation:
Department of Family Medicine, University of Tel Aviv, Tel Aviv, Israel The Maccabi Health Services, Tel-Aviv, Israel
Elizabeth Guerrero-Berroa
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
James Schmeidler
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Ruth Zukran
Affiliation:
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel
Rachel Preiss
Affiliation:
The Maccabi Health Services, Tel-Aviv, Israel
Jeremy M. Silverman
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Mary Sano
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Michal Schnaider Beeri
Affiliation:
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
*
Correspondence should be addressed to: Laili Soleimani, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Phone: 917-499-6743; Fax: 212-996-8931; Email: laili.soleimani@mssm.edu.
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Abstract

Depression and cognitive impairment are highly prevalent in type 2 diabetes (T2D), yet little is known about how their relationship varies by sex. We examined this question in a large T2D sample (N = 897) of non-demented elderly (≥ 65) participating in the Israel Diabetes and Cognitive Decline (IDCD) Study. Cognition was evaluated by a comprehensive neuropsychological battery and depressive symptoms were assessed by the Geriatric Depression Scale (GDS). The results showed that in all but the executive function domain, the association of depressive symptoms with poorer cognitive function was stronger in women than men, with a significant interaction for language/semantic categorization and missed significance for episodic memory. When defining clinical depression as GDS of ≥6, women with depression had significantly poorer language/semantic categorization, episodic memory, and overall cognitive function. Inclusion of antidepressants in the model did not alter substantively the associations. Our results suggest that depressed T2D women may have poorer cognitive performance, highlighting the significance of sex-specific personalized management of depression in elderly diabetics.

Keywords

depressiondiabetescognitive impairmentsex differences
Type
Brief Report
Information
International Psychogeriatrics , Volume 31 , Issue 4: Issue Theme: Aging and Well-Being , April 2019 , pp. 591 - 595
Copyright
© International Psychogeriatric Association 2018 

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