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A randomized controlled trial of Kundalini yoga in mild cognitive impairment

  • Harris A. Eyre (a1) (a2) (a3) (a4), Prabha Siddarth (a1), Bianca Acevedo (a1), Kathleen Van Dyk (a1), Pattharee Paholpak (a1) (a5), Linda Ercoli (a1), Natalie St. Cyr (a1), Hongyu Yang (a1), Dharma S. Khalsa (a6) and Helen Lavretsky (a1)...

Global population aging will result in increasing rates of cognitive decline and dementia. Thus, effective, low-cost, and low side-effect interventions for the treatment and prevention of cognitive decline are urgently needed. Our study is the first to investigate the effects of Kundalini yoga (KY) training on mild cognitive impairment (MCI).


Older participants (≥55 years of age) with MCI were randomized to either a 12-week KY intervention or memory enhancement training (MET; gold-standard, active control). Cognitive (i.e. memory and executive functioning) and mood (i.e. depression, apathy, and resilience) assessments were administered at baseline, 12 weeks and 24 weeks.


At baseline, 81 participants had no significant baseline group differences in clinical or demographic characteristics. At 12 weeks and 24 weeks, both KY and MET groups showed significant improvement in memory; however, only KY showed significant improvement in executive functioning. Only the KY group showed significant improvement in depressive symptoms and resilience at week 12.


KY group showed short- and long-term improvements in executive functioning as compared to MET, and broader effects on depressed mood and resilience. This observation should be confirmed in future clinical trials of yoga intervention for treatment and prevention of cognitive decline (NCT01983930).

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This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
Correspondence should be addressed to: Harris Eyre, MBBS, PhD Student, Discipline of Psychiatry, The University of Adelaide, 55 Frome Road, Adelaide, South Australia, 5005, Australia. Phone: +61-407-694-527. Email:
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International Psychogeriatrics
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