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The recency ratio as predictor of early MCI

  • Davide Bruno (a1), Rebecca L. Koscik (a2), John L. Woodard (a3), Nunzio Pomara (a4) (a5) and Sterling C. Johnson (a2) (a6) (a7)...
Abstract
Objectives:

Individuals with Alzheimer's disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. (Journal of Clinical and Experimental Neuropsychology, Vol. 38, 2016, pp. 967–973) have shown that higher ratio scores between immediate and delayed recency (i.e. the recency ratio; Rr) are associated with cognitive decline in high-functioning older individuals. We tested whether Rr predicted conversion to early mild cognitive impairment (early MCI) from a cognitively healthy baseline.

Design:

Data were analyzed longitudinally with binomial regression. Baseline scores were used to predict conversion to early MCI after approximately nine years. Setting: Data were collected at the Wisconsin Registry of Alzheimer's Prevention, in Madison, Wisconsin.

Participants:

For the study, 427 individuals were included in the analysis; all participants were 50 years of age or older and cognitively intact at baseline, and were native English speakers.

Measurements:

Memory data were collected using the Rey's Auditory Verbal Learning Test, and the early MCI diagnosis was obtained via consensus conference.

Results:

Our results showed that higher Rr scores are correlated with greater risk of later early MCI diagnosis, and this association is independent of total recall performance.

Conclusions:

Rr is an emerging cognitive marker of cognitive decline.

Copyright
Corresponding author
Correspondence should be addressed to: Davide Bruno, Ph.D., School of Natural Science and Psychology, Liverpool John Moores University Liverpool, UK. Phone: +44 (0)151 904 6320. Email: d.bruno@ljmu.ac.uk.
References
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Bruno, D. et al. (2015). A study on the specificity of the association between hippocampal volume and delayed primacy performance in cognitively intact elderly individuals. Neuropsychologia, 69, 18.
Bruno, D. et al. (2017). The recency ratio is associated with reduced CSF glutamate in late-life depression. Neurobiology of Learning and Memory, 141, 1418.
Bruno, D., Reichert, C. and Pomara, N. (2016). The recency ratio as an index of cognitive performance and decline in elderly individuals. Journal of Clinical and Experimental Neuropsychology, 38, 967973.
Bruno, D., Reiss, P. T., Petkova, E., Sidtis, J. J. and Pomara, N. (2013). Decreased recall of primacy words predicts cognitive decline. Archives of Clinical Neuropsychology, 28, 95103.
Carlesimo, G. A., Sabbadini, M., Fadda, L. and Caltagirone, C. (1995). Different components in word-list forgetting of pure amnesics, degenerative demented and healthy subjects. Cortex, 31, 735745.
Clark, L. R. et al. (2016). Mild cognitive impairment in late middle age in the Wisconsin Registry for Alzheimer's Prevention (WRAP) study: prevalence and characteristics using robust and standard neuropsychological normative data. Archives of Clinical Neuropsychology, 31, 675688.
Dowling, N. M., Hermann, B., La Rue, A. and Sager, M. A. (2010). Latent structure and factorial invariance of a neuropsychological test battery for the study of preclinical Alzheimer's disease. Neuropsychology, 24, 742.
Engelman, C. D. et al. (2013). Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin registry for Alzheimer's Prevention. Journal of Alzheimer's Disease, 36, 749757.
Foldi, N. S., Brickman, A. M., Schaefer, L. A. and Knutelska, M. E. (2003). Distinct serial position profiles and neuropsychological measures differentiate late life depression from normal aging and Alzheimer's disease. Psychiatry Research, 120, 7184.
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Koscik, R. L. et al. (2014). Emergence of mild cognitive impairment in late middle-aged adults in the Wisconsin registry for Alzheimer's prevention. Dementia and Geriatric Cognitive Disorders, 38, 1630.
Koscik, R. L. et al. (2016). Intraindividual cognitive variability in middle age predicts cognitive impairment 8–10 years later: results from the Wisconsin registry for Alzheimer's prevention. Journal of the International Neuropsychological Society, 22, 10161025.
Murdock, B. B. (1962). The serial position effect of free recall. Journal of Experimental Psychology, 64, 482488.
Petersen, R. C. et al. (2010). Alzheimer's disease Neuroimaging Initiative (ADNI) clinical characterization. Neurology, 74(3), 201209.
R Core Team (2016). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Available at: https://www.R-project.org/
Sager, M. A., Hermann, B. and La Rue, A. (2005). Middle-aged children of persons with Alzheimer's disease: APOE genotypes and cognitive function in the Wisconsin registry for Alzheimer's prevention. Journal of Geriatric Psychiatry and Neurology, 18, 245249.
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International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
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