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Role of severity and gender in the association between late-life depression and all-cause mortality

  • Hyun-Ghang Jeong (a1), Jung Jae Lee (a2), Seok Bum Lee (a3), Joon Hyuk Park (a4), Yoonseok Huh (a5), Ji Won Han (a5), Tae Hui Kim (a5), Ho Jun Chin (a6) and Ki Woong Kim (a6) (a7)
  • DOI: http://dx.doi.org/10.1017/S1041610212002190
  • Published online: 21 December 2012
Abstract
ABSTRACT

Background: Mortality associated with depression may be influenced by severity of depression and gender. We investigated the differential impacts on all-cause mortality of late-life depression by the type of depression (major depressive disorder, MDD; minor depressive disorder, MnDD; subsyndromal depression, SSD) and gender after adjusting comorbid conditions in the randomly sampled elderly.

Methods: One thousand community-dwelling elderly individuals were enrolled. Standardized face-to-face clinical interviews, neurological examination, and physical examination were conducted to diagnose depressive disorders and comorbid cognitive disorders. Depressive disorders were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria and SSD to study-specific operational criteria. Five-year survivals were compared between groups using Cox proportional hazards models.

Results: By the end of 2010, 174 subjects (17.4%) died. Depressive disorder (p = 0.001) and its interaction term with gender (p < 0.001) were significant in predicting five-year survival. MDD was an independent risk factor for mortality in men (hazard ratio = 3.65, 95% confidence interval = 1.67–7.96) whereas MnDD and SSD were not when other risk factors were adjusted.

Conclusions: MDD may directly confer the risk of mortality in elderly men whereas non-major depression may be just an indicator of increased mortality in both genders.

Copyright
Corresponding author
Correspondence should be addressed to: Ki Woong Kim, Department of Neuropsychiatry, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Korea. Phone: +82-31-7877439; Fax: +82-31-7874058. Email: kwkimmd@snu.ac.kr.
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J. A. Adamson , G. M. Price , E. Breeze , C. J. Bulpitt and A. E. Fletcher (2005). Are older people dying of depression? Findings from the Medical Research Council trial of the assessment and management of older people in the community. Journal of the American Geriatrics Society, 53, 11281132.

S. S. Bassuk , D. Wypij and L. F. Berkman (2000). Cognitive impairment and mortality in the community-dwelling elderly. American Journal of Epidemiology, 151, 676688.

R. M. Carney , K. E. Freedland , G. E. Miller and A. S. Jaffe (2002). Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. Journal of Psychosomatic Research, 53, 897902.

P. Cuijpers and F. Smit (2002). Excess mortality in depression: a meta-analysis of community studies. Journal of Affective Disorders, 72, 227236.

L. C. Dierker , S. Avenevoli , M. Stolar and K. R. Merikangas (2002). Smoking and depression: an examination of mechanisms of comorbidity. American Journal of Psychiatry, 159, 947953.

A. Y. Dombrovski , K. Szanto , P. Duberstein , K. R. Conner , P. R. Houck and Y. Conwell (2008). Sex differences in correlates of suicide attempt lethality in late life. American Journal of Geriatric Psychiatry, 16, 905913.

M. J. Forlenza and G. E. Miller (2006). Increased serum levels of 8-hydroxy-2′-deoxyguanosine in clinical depression. Psychosomatic Medicine, 68, 17.

L. Fredman et al. (1989). The association between depressive symptoms and mortality among older participants in the Epidemiologic Catchment Area-Piedmont Health Survey. Journal of Gerontology, 44, S149S156.

G. B. Frisoni , L. Fratiglioni , J. Fastbom , M. Viitanen and B. Winblad (1999). Mortality in nondemented subjects with cognitive impairment: the influence of health-related factors. American Journal of Epidemiology, 150, 10311044.

J. J. Gallo , P. V. Rabins , C. G. Lyketsos , A. Y. Tien and J. C. Anthony (1997). Depression without sadness: functional outcomes of nondysphoric depression in later life. Journal of the American Geriatrics Society, 45, 570578.

J. J. Gallo , H. R. Bogner , K. H. Morales , E. P. Post , Ten T. Have and M. L. Bruce (2005). Depression, cardiovascular disease, diabetes, and two-year mortality among older, primary-care patients. American Journal of Geriatric Psychiatry, 13, 748755.

A. L. Gross , J. J. Gallo and W. W. Eaton (2010). Depression and cancer risk: 24 years of follow-up of the Baltimore Epidemiologic Catchment Area sample. Cancer Causes and Control, 21, 191199.

M. Hamilton (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278296.

E. C. Harris and B. Barraclough (1998). Excess mortality of mental disorder. British Journal of Psychiatry, 173, 1153.

K. Hawton (2000). Sex and suicide: gender differences in suicidal behaviour. British Journal of Psychiatry, 177, 484485.

M. L. Hermens et al. (2004). The prognosis of minor depression in the general population: a systematic review. General Hospital Psychiatry, 26, 453462.

M. Irie , S. Asami , S. Nagata , M. Ikeda , M. Miyata and H. Kasai (2001). Psychosocial factors as a potential trigger of oxidative DNA damage in human leukocytes. Japanese Journal of Cancer Research, 92, 367376.

M. Irie , M. Miyata and H. Kasai (2005). Depression and possible cancer risk due to oxidative DNA damage. Journal of Psychiatric Research, 39, 553560.

H. G. Jeong et al. (2012a). Plasma adiponectin elevation in elderly individuals with subsyndromal depression. Psychoneuroendocrinology, 37, 948955.

H. G. Jeong et al. (2012b). Impact of alcohol use on mortality in the elderly: results from the Korean Longitudinal Study on Health and Aging. Drug and Alcohol Dependence, 121, 133139.

W. Jiang (2008). Impacts of depression and emotional distress on cardiac disease. Cleveland Clinic Journal of Medicine, 75, S20S25.

F. B. Johnson , D. A. Sinclair and L. Guarente (1999). Molecular biology of aging. Cell, 96, 291302.

J. Y. Kim et al. (2008). Standardization of the Korean version of the Geriatric Depression Scale: reliability, validity, and factor structure. Psychiatry Investigation, 5, 232238.

K. W. Kim et al. (2009). Prevalence and neuropsychiatric comorbidities of alcohol use disorders in an elderly Korean population. International Journal of Geriatric Psychiatry, 24, 14201428.

H. K. Kim , J. H. Park and J. H. Kim (2010). Differences in adherence to antihypertensive medication regimens according to psychiatric diagnosis: results of a Korean population-based study. Psychosomatic Medicine, 72, 8087.

H. Lavretsky and A. Kumar (2002). Clinically significant non-major depression: old concepts, new insights. American Journal of Geriatric Psychiatry, 10, 239255.

J. H. Lee et al. (2002). Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries. Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 57, P47P53.

D. Y. Lee et al. (2004). A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. Journal of the International Neuropsychological Society, 10, 7281.

R. C. May (2007). Gender, immunity and the regulation of longevity. Bioessays, 29, 795802.

M. D. Miller et al. (1992). Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Research, 41, 237248.

M. A. Oquendo , S. P. Ellis , S. Greenwald , K. M. Malone , M. M. Weissman and J. J. Mann (2001). Ethnic and sex differences in suicide rates relative to major depression in the United States. American Journal of Psychiatry, 158, 16521658.

A. Pan , Q. Sun , O. I. Okereke , K. M. Rexrode and F. B. Hu (2011). Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review. JAMA, 306, 12411249.

J. H. Park et al. (2010). Prevalence of major depressive disorder and minor depressive disorder in an elderly Korean population: results from the Korean Longitudinal Study on Health and Aging (KLoSHA). Journal of Affective Disorders, 125, 234240.

J. H. Park et al. (2012). A nationwide survey on the prevalence and risk factors of late life depression in South Korea. Journal of Affective Disorders, 138, 3440.

G. Parker and H. Brotchie (2010). Gender differences in depression. International Review of Psychiatry, 22, 429436.

B. W. Penninx , S. W. Geerlings , D. J. Deeg , J. T. van Eijk , W. van Tilburg and A. T. Beekman (1999). Minor and major depression and the risk of death in older persons. Archives of General Psychiatry, 56, 889895.

L. A. Pratt , D. E. Ford , R. M. Crum , H. K. Armenian , J. J. Gallo and W. W. Eaton (1996). Depression, psychotropic medication, and risk of myocardial infarction: prospective data from the Baltimore ECA follow-up. Circulation, 94, 31233129.

C. A. Roeloffs , A. Fink , J. Unützer , L. Tang and K. B. Wells (2001). Problematic substance use, depressive symptoms, and gender in primary care. Psychiatric Services, 52, 12511253.

J. Ryan et al. (2008). Late-life depression and mortality: influence of gender and antidepressant use. British Journal of Psychiatry, 192, 1218.

P. Saz and M. E. Dewey (2001). Depression, depressive symptoms and mortality in persons aged 65 and over living in the community: a systematic review of the literature. International Journal of Geriatric Psychiatry, 16, 622630.

R. A. Schoevers et al. (2000). Association of depression and gender with mortality in old age: results from the Amsterdam Study of the Elderly (AMSTEL). British Journal of Psychiatry, 177, 336342.

A. Sherwood et al. (2007). Relationship of depression to death or hospitalization in patients with heart failure. Archives of Internal Medicine, 167, 367373.

N. M. Simon et al. (2006). Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biological Psychiatry, 60, 432435.

J. Viña , C. Borrás , J. Gambini , J. Sastre and F. V. Pallardó (2005). Why females live longer than males: control of longevity by sex hormones. Science of Aging Knowledge Environment, 2005, pe17.

M. Wingen , J. G. Ramaekers and J. A. Schmitt (2006). Driving impairment in depressed patients receiving long-term antidepressant treatment. Psychopharmacology, 188, 8491.

L. R. Wulsin , G. E. Vaillant and V. E. Wells (1999). A systematic review of the mortality of depression. Psychosomatic Medicine, 61, 617.

L. R. Wulsin , J. C. Evans , R. S. Vasan , J. M. Murabito , M. Kelly-Hayes and E. J. Benjamin (2005). Depressive symptoms, coronary heart disease, and overall mortality in the Framingham Heart Study. Psychosomatic Medicine, 67, 697702.

S. Yager , M. J. Forlenza and G. E. Miller (2010). Depression and oxidative damage to lipids. Psychoneuroendocrinology, 35, 13561362.

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