Skip to main content Accessibility help
×
×
Home

Sleep disturbances in older adults with mild cognitive impairment

  • Simon Beaulieu-Bonneau (a1) and Carol Hudon (a1)

Abstract

Background: Normal aging and dementia are characterized by increased prevalence of sleep disorders and alterations of both sleep continuity and architecture. However, little is still known about the nature of sleep in mild cognitive impairment (MCI), which is presumably situated on the continuum from healthy aging to dementia. This unsystematic review summarizes the current literature on the prevalence and severity of sleep disturbances in MCI.

Methods: Eighteen studies addressing sleep/night-time disturbances among other neuropsychiatric symptoms in individuals with MCI were identified through a search of databases and an examination of reference lists of selected papers. Fifteen of those studies reported data on prevalence or severity of sleep/night-time disturbances.

Results: Results indicated that 14–59% of patients with MCI had sleep disturbances. These disturbances were often identified as one of the four most prevalent neuropsychiatric symptoms of MCI and were considered as clinically significant in some studies. In addition, there was some evidence that the prevalence of sleep disturbances in MCI is intermediate between that of normal aging and dementia. Longitudinal data suggest that sleep problems are associated with both incident MCI and dementia.

Conclusions: These findings support the hypothesis that sleep disturbances are one of the core non-cognitive symptoms of MCI. It remains to be known whether sleep problems could help to identify those individuals with MCI who will eventually develop dementia. Studies characterizing sleep more systematically are needed to verify this proposition and to clarify the associations between sleep disturbances and other neuropsychiatric symptoms of MCI.

Copyright

Corresponding author

Correspondence should be addressed to: Carol Hudon, PhD, École de psychologie, Pavillon Félix-Antoine-Savard, Université Laval, 2325, rue des Bibliothèques, Local 1546, Québec, CanadaG1V 0A6. Phone: +1 418 663 5741 ext. 4779; Fax: +1 418 663 5971. Email: carol.hudon@psy.ulaval.ca.

References

Hide All
Apostolova, L. G. and Cummings, J. L. (2008). Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature. Dementia and Geriatric Cognitive Disorders, 25, 115126.
Artero, S., Petersen, R., Touchon, J. and Ritchie, K. (2006). Revised criteria for mild cognitive impairment: validation within a longitudinal population study. Dementia and Geriatric Cognitive Disorders, 22, 465470.
Åsberg, M., Montgomery, S. A., Perris, C., Schalling, D. and Sedvall, G. (1978). A comprehensive psychopathological rating scale. Acta Psychiatrica Scandinavica, 57 (Suppl. 271), 527.
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. and Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561571.
Boeve, B. F., Silber, M. H. and Ferman, T. J. (2004). REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies. Journal of Geriatric Psychiatry and Neurology, 17, 146157.
Chiu, P. Y., Liu, C. H. and Tsai, C. H. (2007). Neuropsychiatric manifestations in vascular cognitive impairment patients with and without dementia. Acta Neurologica Taiwanica, 16, 8691.
Cole, C. S. and Richards, K. C. (2005). Sleep and cognition in people with Alzheimer's disease. Issues in Mental Health Nursing, 26, 687698.
Copeland, J. R. et al. (1976). A semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: the Geriatric Mental State Schedule. I. Development and reliability. Psychological Medicine, 6, 439449.
Cricco, M., Simonsick, E. M. and Foley, D. J. (2001). The impact of insomnia on cognitive functioning in older adults. Journal of the American Geriatrics Society, 49, 11851189.
Cummings, J. L. (1997). The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology, 48, S1016.
Dauvilliers, Y. (2007). Insomnia in patients with neurodegenerative conditions. Sleep Medicine, 8 (Suppl. 4), S2734.
Ebly, E. M., Hogan, D. B. and Parhad, I. M. (1995). Cognitive impairment in the nondemented elderly: results from the Canadian Study of Health and Aging. Archives of Neurology, 52, 612619.
Edwards, E. R., Spira, A. P., Barnes, D. E. and Yaffe, K. (2009). Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia. International Journal of Geriatric Psychiatry. E-published ahead of print; doi: 10.1002/gps.2187.
Ellison, J. M., Harper, D. G., Berlow, Y. and Zeranski, L. (2008). Beyond the “C” in MCI: noncognitive symptoms in amnestic and non-amnestic mild cognitive impairment. CNS Spectrums, 13, 6672.
Espiritu, J. R. (2008). Aging-related sleep changes. Clinics in Geriatric Medicine, 24, 114.
Feldman, H. et al. (2004). Behavioral symptoms in mild cognitive impairment. Neurology, 62, 11991201.
Foley, D. et al. (2001). Daytime sleepiness is associated with 3-year incident dementia and cognitive decline in older Japanese-American men. Journal of the American Geriatrics Society, 49, 16281632.
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Forsell, Y., Palmer, K. and Fratiglioni, L. (2003). Psychiatric symptoms/syndromes in elderly persons with mild cognitive impairment: data from a cross-sectional study. Acta Neurologica Scandinavica, 107, 2528.
Gabryelewicz, T. et al. (2004). Prevalence of major and minor depression in elderly persons with mild cognitive impairment – MADRS factor analysis. International Journal of Geriatric Psychiatry, 19, 11681172.
Gagnon, J. F., Postuma, R. B., Mazza, S., Doyon, J. and Montplaisir, J. (2006). Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurology, 5, 424432.
Gallassi, R., Bisulli, A., Oppi, F., Poda, R. and Di Felice, C. (2008). Subjective cognitive complaints, neuropsychological performance, affective and behavioural symptoms in non-demented patients. International Journal of Geriatric Psychiatry, 23, 95101.
Geda, Y. E. et al. (2004). De novo genesis of neuropsychiatric symptoms in mild cognitive impairment (MCI). International Psychogeriatrics, 16, 5160.
Geda, Y. E. et al. (2008). Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study. Archives of General Psychiatry, 65, 11931198.
Goldberg, D., Bridges, K., Duncan-Jones, P. and Grayson, D. (1988). Detecting anxiety and depression in general medical settings. BMJ, 297, 897899.
Hogan, D. B. et al. (2007). Management of mild to moderate Alzheimer's disease and dementia. Alzheimer's and Dementia, 3, 355384.
Jeste, D. V., Meeks, T. W., Kim, D. S. and Zubenko, G. S. (2006). Research agenda for DSM-V: diagnostic categories and criteria for neuropsychiatric syndromes in dementia. Journal of Geriatric Psychiatry and Neurology, 19, 160171.
Kaufer, D. I. et al. (2000). Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. Journal of Neuropsychiatry and Clinical Neurosciences, 12, 233239.
Kluger, A., Ferris, S. H., Golomb, J., Mittelman, M. S. and Reisberg, B. (1999). Neuropsychological prediction of decline to dementia in nondemented elderly. Journal of Geriatric Psychiatry and Neurology, 12, 168179.
Kumar, R., Jorm, A. F., Parslow, R. A. and Sachdev, P. S. (2006). Depression in mild cognitive impairment in a community sample of individuals 60–64 years old. International Psychogeriatrics, 18, 471480.
Lee, K. S., Cho, H. S., Hong, C. H., Kim, D. G. and Oh, B. H. (2008). Differences in neuropsychiatric symptoms according to mild cognitive impairment subtypes in the community. Dementia and Geriatric Cognitive Disorders, 26, 212217.
Lobo, A., Lopez-Anton, R., de la Camara, C., Quintanilla, M. A., Campayo, A. and Saz, S. (2008). Non-cognitive psychopathological symptoms associated with incident mild cognitive impairment and dementia, Alzheimer's type. Neurotoxicity Research, 14, 263272.
Lopez, O. L. et al. (2003). Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. Archives of Neurology, 60, 13851389.
Lopez, O. L., Becker, J. T. and Sweet, R. A. (2005). Non-cognitive symptoms in mild cognitive impairment subjects. Neurocase, 11, 6571.
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J. and DeKosky, S. (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. JAMA, 288, 14751483.
Martin, J. L. and Ancoli-Israel, S. (2008). Sleep disturbances in long-term care. Clinics in Geriatric Medicine, 24, 3950.
Montgomery, S. A. and Åsberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382389.
Morris, J. C. (1993). The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology, 43, 24122414.
Muangpaisan, W., Intalapaporn, S. and Assantachai, P. (2008). Neuropsychiatric symptoms in the community-based patients with mild cognitive impairment and the influence of demographic factors. International Journal of Geriatric Psychiatry, 23, 699703.
National Institutes of Health (2005). NIH State of the Science Conference statement on Manifestations and Management of Chronic Insomnia in Adults. Journal of Clinical Sleep Medicine, 1, 412421.
Ohayon, M. M., Carskadon, M. A., Guilleminault, C. and Vitiello, M. V. (2004). Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep, 27, 12551273.
Onor, M. L., Trevisiol, M., Negro, C. and Aguglia, E. (2006). Different perception of cognitive impairment, behavioral disturbances, and functional disabilities between persons with mild cognitive impairment and mild Alzheimer's disease and their caregivers. American Journal of Alzheimer's Disease and Other Dementias, 21, 333338.
Pachana, N. A., Byrne, G. J., Siddle, H., Koloski, N., Harley, E. and Arnold, E. (2007). Development and validation of the Geriatric Anxiety Inventory. International Psychogeriatrics, 19, 103114.
Peters, K. R. et al. (2006). Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics. Neurology, 66, 523528.
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194.
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G. and Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56, 303308.
Petersen, R. C. et al. (2001). Current concepts in mild cognitive impairment. Archives of Neurology, 58, 19851992.
Reisberg, B. and Gauthier, S. (2008). Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease. International Psychogeriatrics, 20, 116.
Rozzini, L. et al. (2008a). Mild parkinsonian signs and psycho-behavioral symptoms in subjects with mild cognitive impairment. International Psychogeriatrics, 20, 8695.
Rozzini, L. et al. (2008b). Neuropsychiatric symptoms in amnestic and nonamnestic mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 25, 3236.
Rozzini, L. et al. (2008c). Anxiety symptoms in mild cognitive impairment. International Journal of Geriatric Psychiatry, 24, 300305.
Spitzer, R. L., Kroenke, K. and Williams, J. B. (1999). Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study, Primary Care Evaluation of Mental Disorders: Patient Health Questionnaire. JAMA, 282, 17371744.
Steffens, D. C. et al. (2006). Perspectives on depression, mild cognitive impairment, and cognitive decline. Archives of General Psychiatry, 63, 130138.
Tariot, P. N. et al. (1995). The Behavior Rating Scale for dementia of the consortium to establish a registry for Alzheimer's disease. The Behavioral Pathology Committee of the Consortium to Establish a Registry for Alzheimer's Disease. American Journal of Psychiatry, 152, 13491357.
Tatsch, M. F. et al. (2006). Neuropsychiatric symptoms in Alzheimer disease and cognitively impaired, nondemented elderly from a community-based sample in Brazil: prevalence and relationship with dementia severity. American Journal of Geriatric Psychiatry, 14, 438445.
Teng, E., Lu, P. H. and Cummings, J. L. (2007). Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 24, 253259.
Winblad, B. et al. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240246.
Yesavage, J. A. et al. (2003). Development of diagnostic criteria for defining sleep disturbance in Alzheimer's disease. Journal of Geriatric Psychiatry and Neurology, 16, 131139.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

International Psychogeriatrics
  • ISSN: 1041-6102
  • EISSN: 1741-203X
  • URL: /core/journals/international-psychogeriatrics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed