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Staging: Relevance for Trial Design in Vascular Burden of the Brain

Published online by Cambridge University Press:  10 January 2005

Barry Reisberg ,
Steven H. Ferris ,
Thet Oo  and
Emile Franssen
Barry Reisberg
Affiliation:
William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, US
Steven H. Ferris
Affiliation:
William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, US
Thet Oo
Affiliation:
William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, US
Emile Franssen
Affiliation:
William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, US
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Abstract

Cerebrovascular small vessel disease is now believed to be the major source of vascular burden of the brain. Cerebrovascular small vessel disease and Alzheimer's disease appear to represent pathophysiologic and clinical continua, rather than dichotomous entities. It appears that common etiopathologic mechanisms underlie the clinical presentation of both of these conditions. Therefore, the staging procedures that have been developed for the clinical continuum of age-associated memory impairment, mild cognitive impairment, and the progressive dementia of Alzheimer's disease appear to be applicable for the same continua in cerebrovascular small vessel disease. Although temporal and prognostic aspects have been studied for the Alzheimer's-related portions of this clinical staging continuum, they remain to be elucidated for cerebrovascular small vessel disease.

Keywords

Stagingcerebrovascular diseaseAlzheimer's diseasedementiamild cognitive impairmentage-associated memory impairment
Type
TRIAL DESIGNS: SYMPTOMATIC
Information
International Psychogeriatrics , Volume 15 , Issue S1 , July 2003 , pp. 231 - 239
Copyright
© 2003 International Psychogeriatric Association

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