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Tau accumulation in two patients with frontotemporal lobe degeneration showing different types of aphasia using 18F-THK-5351 positron emission tomography: a case report

  • Masahiko Takaya (a1), Kazunari Ishii (a2), Chisa Hosokawa (a2), Kazumasa Saigoh (a3) and Osamu Shirakawa (a1)...

Abstract

Tau deposits in Alzheimer's disease and corticobasal syndrome have been reported using 18F-THK-5351 positron emission tomography (PET). To our knowledge, our study is the first to demonstrate tau deposits in patients with frontotemporal lobe degeneration (FTLD), using 18F-THK-5351 PET. This case report presents two patients, both of whom showed positive Tau deposition using 18F-THK-5351 PET. One patient was diagnosed with semantic variant primary progressive aphasia (PPA) and the other diagnosed with logopenic variant PPA. Our results suggest an association in the pathology of Alzheimer's disease, corticobasal syndrome, and FTLD, and could plan more effective clinical care in advance.

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Corresponding author

Correspondence should be addressed to: Masahiko Takaya, MD, PhD, Department of Neuropsychiatry, Kindai University Faculty of Medicine, 377-2, Onohigashi, Osakasayama, Osaka, 589–8511, Japan. Phone +81-72-366-0221. Email: takaya@med.kindai.ac.jp.

References

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Keywords

Tau accumulation in two patients with frontotemporal lobe degeneration showing different types of aphasia using 18F-THK-5351 positron emission tomography: a case report

  • Masahiko Takaya (a1), Kazunari Ishii (a2), Chisa Hosokawa (a2), Kazumasa Saigoh (a3) and Osamu Shirakawa (a1)...

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