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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL): a familial cause of depression and headache

Published online by Cambridge University Press:  13 June 2014

Killian O'Rourke
Affiliation:
Mater Hospital, Dublin 7
Niall Crumlish
Affiliation:
St. James's Hospital, Dublin 8
Darra Murphy
Affiliation:
Mater Hospital, Dublin 7
John Stack
Affiliation:
Mater Hospital, Dublin 7
Brian Murray
Affiliation:
Mater Hospital, Dublin 7, Ireland

Abstract

A 31 year-old man with a history of a depressive episode presented with acute severe ‘thunderclap’ headache. Magnetic resonance imaging (MRI) revealed abnormalities typical of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL), which was subsequently confirmed by genetic analysis. The psychiatric features of this genetic cause of depression and headache are discussed.

Type
Case reports
Copyright
Copyright © Cambridge University Press 2010

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