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An asymptotic formula for the transition density of random genetic drift

  • Peter L. Antonelli (a1)
Abstract

Stochastic models in population genetics which lead to diffusion equations are considered. A geometric formula for the asymptotic expansions of the fundamental solutions of these equations is presented. Specifically, the random genetic drift process of one-locus theory and the Ohta–Kimura model of two-locus di-allelic systems with linkage are studied. Agreement with the work of Keller and Voronka for the two-allele one-locus case is obtained. For the general n-allele problem, the formulas obtained here are apparently new.

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[1] Antonelli, P. L. and Strobeck, C. (1977) The geometry of random drift, I. Stochastic distance and diffusion. Adv. Appl. Prob. 9, 238249.
[2] Antonelli, P. L., Morgan, K. and Lathrop, G. M. (1977) The geometry of random drift, III. Recombination and diffusion. Adv. Appl. Prob. 9, 260267.
[3] Friedman, A. (1975) Stochastic Differential Equations and Applications, Vol. I. Academic Press, New York.
[4] Helgason, S. (1961) Differential Geometry and Symmetric Spaces. Academic Press, New York.
[5] Keller, J. B. and Voronka, R. (1975) Asymptotic analysis of stochastic models in population genetics. Math. Biosci. 25, 331362.
[6] Molchanov, S. A. (1975) Diffusion processes and Riemannian geometry. Russian Math. Survey 30, 175.
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Journal of Applied Probability
  • ISSN: 0021-9002
  • EISSN: 1475-6072
  • URL: /core/journals/journal-of-applied-probability
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