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TYPES OF MARRIAGES, POPULATION STRUCTURE AND GENETIC DISEASE

Published online by Cambridge University Press:  25 October 2012

T. M. B. MACHADO
Affiliation:
Gonçalo Moniz Research Center (CPqGM)/Oswaldo Cruz Foundation-BA, Brazil Laboratory of Immunology and Molecular Biology – Institute of Health Science, Federal University of Bahia (Labimuno/ICS/UFBA), Brazil
T. F. BOMFIM
Affiliation:
Gonçalo Moniz Research Center (CPqGM)/Oswaldo Cruz Foundation-BA, Brazil Laboratory of Immunology and Molecular Biology – Institute of Health Science, Federal University of Bahia (Labimuno/ICS/UFBA), Brazil
L. V. SOUZA
Affiliation:
Federal Institute of Education, Science and Technology of Bahia (IFBA), Brazil
N. SOARES
Affiliation:
Gonçalo Moniz Research Center (CPqGM)/Oswaldo Cruz Foundation-BA, Brazil
F. L. SANTOS
Affiliation:
Federal University of Bahia Reconcavo (UFRB), Brazil
A. X. ACOSTA
Affiliation:
Gonçalo Moniz Research Center (CPqGM)/Oswaldo Cruz Foundation-BA, Brazil School of Medicine of Bahia – Federal University of Bahia (UFBA), Brazil
K. ABE-SANDES
Affiliation:
Gonçalo Moniz Research Center (CPqGM)/Oswaldo Cruz Foundation-BA, Brazil State University of Bahia (UNEB), Brazil Laboratory of Immunology and Molecular Biology – Institute of Health Science, Federal University of Bahia (Labimuno/ICS/UFBA), Brazil Federal University of Bahia Reconcavo (UFRB), Brazil

Summary

A high occurrence rate of consanguineous marriages may favour the onset and increased frequency of autosomal recessive diseases in a population. The population of Monte Santo, Bahia, Brazil, has a high frequency of rare genetic diseases such as mucopolysaccharidosis type VI, whose observed frequency in this population is 1:5000, while the incidence of this disease recorded in other regions of the world varies from 1:43,261 in Turkey to 1:1,505,160 in Switzerland. To verify the influence of consanguineous marriage on the increased frequency of observed genetic diseases in this population, the population structure and frequency of different types of marriage during different time periods were evaluated. A total of 9765 marriages were found in an analysis of parish marriage records from the city. Over three periods, 1860–1895, 1950–1961 and 1975–2010, the inbreeding rates were 37.1%, 13.2% and 4.2% respectively. Although there was a high rate of inbreeding, endogamic marriages were the dominant marriage type in all three periods. In the most recent period, there was an increase in the number of exogamous marriages and those among immigrants, but most of these occurred among individuals from cities that neighbour Monte Santo. The low rate of migration and high frequency of endogamic and consanguineous marriages show that growth of this population is predominantly internal and could explain the occurrence, and increase in frequency, of recessive genetic diseases in the city.

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Articles
Copyright
Copyright © Cambridge University Press 2012 

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