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Effect of combined acetylmethionine, cyanocobalamin and α-lipoic acid on hepatic metabolism in high-yielding dairy cow

Published online by Cambridge University Press:  15 November 2016

Enrico Fiore ,
Laura Perillo ,
Giuseppe Piccione ,
Matteo Gianesella ,
Silvia Bedin ,
Leonardo Armato ,
Elisabetta Giudice  and
Massimo Morgante
Enrico Fiore
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Laura Perillo
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Giuseppe Piccione*
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Matteo Gianesella
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Silvia Bedin
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Leonardo Armato
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
Elisabetta Giudice
Affiliation:
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166, S. Agata-Messina, Italy
Massimo Morgante
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 35020 Legnaro (PD), Italy
*
*For correspondence; e-mail: gpiccione@unime.it
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Abstract

The aim of the study reported in this Research Communication was to investigate the effect of a combined acetylmethionine, cyanocobalamin and α-lipoic acid treatment, on some metabolic parameters of early lactating high-yielding dairy cows. Thirty cows were randomly divided into two groups: experimental group (EG, n = 20) and control group (CG, n = 10). EG received 20 ml of treatment and CG received 20 ml of placebo. The treatments were administered for seven times every 2 d. Blood samples were collected from all cows at 3 time points: 10 ± 2, 30 ± 2 and 50 ± 2 d postpartum. Glucose, β-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), triglycerides, total cholesterol (TC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamiltransferase (GGT), total bilirubin (TB), conjugated bilirubin (CB), total proteins (TP), globulins, albumin and urea concentrations were determined. Two-way repeated measure analysis of variance was applied. Significant differences in the values of glucose, BHB, NEFA, triglycerides, TC, AST and urea were found between EG and CG. Moreover, the increased glucose, TC, ALT, GGT, TP and globulins, and the reduced BHB, NEFA, AST, triglycerides, TB, CB and urea concentrations were evident in both groups, but the changes were more pronounced in EG. Our findings indicate that our treatment positively influenced liver metabolism in high-yielding dairy cows.

Keywords

Acetylmethioninecyanocobalaminα-lipoic acidlivercow
Type
Research Article
Information
Journal of Dairy Research , Volume 83 , Issue 4 , November 2016 , pp. 438 - 441
Copyright
Copyright © Proprietors of Journal of Dairy Research 2016 

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