Skip to main content
×
×
Home

Effect of combined acetylmethionine, cyanocobalamin and α-lipoic acid on hepatic metabolism in high-yielding dairy cow

  • Enrico Fiore (a1), Laura Perillo (a2), Giuseppe Piccione (a2), Matteo Gianesella (a1), Silvia Bedin (a1), Leonardo Armato (a1), Elisabetta Giudice (a3) and Massimo Morgante (a1)...
Abstract

The aim of the study reported in this Research Communication was to investigate the effect of a combined acetylmethionine, cyanocobalamin and α-lipoic acid treatment, on some metabolic parameters of early lactating high-yielding dairy cows. Thirty cows were randomly divided into two groups: experimental group (EG, n = 20) and control group (CG, n = 10). EG received 20 ml of treatment and CG received 20 ml of placebo. The treatments were administered for seven times every 2 d. Blood samples were collected from all cows at 3 time points: 10 ± 2, 30 ± 2 and 50 ± 2 d postpartum. Glucose, β-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), triglycerides, total cholesterol (TC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamiltransferase (GGT), total bilirubin (TB), conjugated bilirubin (CB), total proteins (TP), globulins, albumin and urea concentrations were determined. Two-way repeated measure analysis of variance was applied. Significant differences in the values of glucose, BHB, NEFA, triglycerides, TC, AST and urea were found between EG and CG. Moreover, the increased glucose, TC, ALT, GGT, TP and globulins, and the reduced BHB, NEFA, AST, triglycerides, TB, CB and urea concentrations were evident in both groups, but the changes were more pronounced in EG. Our findings indicate that our treatment positively influenced liver metabolism in high-yielding dairy cows.

Copyright
Corresponding author
*For correspondence; e-mail: gpiccione@unime.it
References
Hide All
Duffield, TF, LeBlanc, S, Bagg, R, Leslie, K, Ten Hag, J & Dick, P 2003 Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. Journal of Dairy Science 86 11711176
Edmonson, AJ, Lean, IJ, Weaver, LD, Farver, T & Webster, G 1989 A body condition scoring chart for Holstein dairy cows. Journal of Dairy Science 72 6878
Fiore, E, Gianesella, M, Arfuso, F, Giudice, E, Piccione, G, Lora, M, Stefani, A & Morgante, M 2014 Glucose infusion response on some metabolic parameters in dairy cows during transition period. Archiv Tierzucht 57 19
Fürll, M, Deniz, A, Westphal, B, Illing, C & Constable, PD 2010 Effect of multiple intravenous injections of butaphosphan and cyanocobalamin on the metabolism of periparturient dairy cows. Journal of Dairy Science 93 41554164
Kreipe, L, Deniz, A, Bruckmaier, RM & van Dorland, HA 2011 First report about the mode of action of combined butafosfan and cyanocobalamin on hepatic metabolism in nonketotic early lactating cows. Journal of Dairy Science 94 49044914
Nielsen, NI & Ingvartsen, KL 2004 Propylene glycol for dairy cows A review of the metabolism of propylene glycol and its effects on physiological parameters, feed intake, milk production and risk of ketosis. Animal Feed Science and Technology 115 191213
Piccione, G, Messina, V, Marafioti, S, Casella, S, Giannetto, C & Fazio, F 2012 Changes of some haematochemical parameters in dairy cows during late gestation, post partum, lactation and dry periods. Veterinarija Ir Zootechnika 58 5964
Preynat, A, Lapierre, H, Thivierge, MC, Palin, MF, Matte, JJ, Desrochers, A & Girard, CL 2009 Influence of methionine supply on the response of lactational performance of dairy cows to supplementary folic acid and vitamin B12. Journal of Dairy Science 92 16851695
Roubies, N, Panouis, N, Fytianou, A, Katsoulos, PD, Giadinis, N & Karatzias, H 2006 Effects of age and reproductive stage on certain serum biochemical parameters of Chios sheep under greek rearing conditions. Journal of Veterinary Medicine Series A-Physiology Pathology Clinical Medicine 53 277281
Stojević, Z, Piršljin, J, Milinković-Tur, S, Zdelar-Tuk, M & Ljubić, BB 2005 Activities of AST, ALT and GGT in clinically healthy dairy cows during lactation and in the dry period. Veterinarski Arhiv 75 6773
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Dairy Research
  • ISSN: 0022-0299
  • EISSN: 1469-7629
  • URL: /core/journals/journal-of-dairy-research
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Type Description Title
PDF
Supplementary materials

Fiore supplementary material
Table S1

 PDF (202 KB)
202 KB

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed