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A meta-analysis of neonatal health outcomes from oocyte donation

  • D. H. Adams (a1), R. A. Clark (a1), M. J. Davies (a2) (a3) and S. de Lacey (a1)
Abstract

Donated oocytes are a treatment modality for female infertility which is also associated with increased risks of preeclampsia. Subsequently it is important to evaluate if there is concomitant increased risks for adverse neonatal events in donated oocyte neonates. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the perinatal health outcomes of offspring conceived from donor oocytes compared with autologous oocytes. Meta-analysis was performed on comparable outcomes data. Twenty-eight studies were eligible and included in the review, and of these, 23 were included in a meta-analysis. Donor oocyte neonates are at increased risk of being born with low birth weight (<2500 g) [risk ratio (RR): 1.18, 95% confidence interval (CI): 1.14–1.22, P-value (P)<0.00001], very low birth weight (<1500 g) (RR: 1.24, CI: 1.15–1.35, P<0.00001), preterm (<37 weeks) (RR: 1.26, CI: 1.23–1.30, P<0.00001), of lower gestational age (mean difference −0.3 weeks, CI: −0.35 weeks to −0.25 weeks, P<0.00001), and preterm with low birth weight (RR: 1.24, CI: 1.19–1.29, P<0.00001), when compared with autologous oocyte neonates. Conversely, low birth weight outcomes were improved in term donor oocyte neonates (RR: 0.86, CI: 0.8–0.93, P=0.0003). These negative outcomes remained significant when controlling for multiple deliveries. The donor oocyte risk rates are higher than those found in general ART outcomes, are important considerations for the counselling of infertile patients and may also influence the long term health of the offspring.

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Corresponding author
*Address for correspondence: D. H. Adams, School of Nursing and Midwifery, Flinders University, Bedford Park, SA 5042, Australia. (Email: adam0072@flinders.edu.au)
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2.JL Marino , VM Moore , KJ Willson , et al. Perinatal outcomes by mode of assisted conception and sub-fertility in an Australian data linkage cohort. PLoS One. 2014; 9, e80398.

3.M Hansen , JJ Kurinczuk , E Milne , N de Klerk , C Bower . Assisted reproductive technology and birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2013; 19, 330353.

4.A Pinborg , UB Wennerholm , LB Romundstad , et al. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update. 2013; 19, 87104.

5.VS Talaulikar , S Arulkumaran . Reproductive outcomes after assisted conception. Obstet Gynecol Surv. 2012; 67, 566583.

6.SD McDonald , Z Han , S Mulla , et al. Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses. Eur J Obstet Gynecol Reprod Biol. 2009; 146, 138148.

7.FM Helmerhorst , DA Perquin , D Donker , MJ Keirse . Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ. 2004; 328, 261.

8.QA Class , ME Rickert , P Lichtenstein , BM D’Onofrio . Birth weight, physical morbidity, and mortality: a population-based sibling-comparison study. Am J Epidemiol. 2014; 179, 550558.

9.K Calkins , SU Devaskar . Fetal origins of adult disease. Curr Probl Pediatr Adolesc Health Care. 2011; 41, 158176.

11.A Batcheller , E Cardozo , M Maguire , AH DeCherney , JH Segars . Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies? Fertil Steril. 2011; 96, 13061311.

13.PC Klatsky , SS Delaney , AB Caughey , et al. The role of embryonic origin in preeclampsia: a comparison of autologous in vitro fertilization and ovum donor pregnancies. Obstet Gynecol. 2010; 116, 13871392.

14.O Salha , V Sharma , T Dada , et al. The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod. 1999; 14, 22682273.

15. SSaito , AShiozaki , ANakashima , MSakai , YSasaki . The role of the immune system in preeclampsia. Mol Aspects Med. 2007; 28, 192209.

16.IL Sargent , AM Borzychowski , CW Redman . Immunoregulation in normal pregnancy and pre-eclampsia: an overview. Reprod Biomed Online. 2006; 13, 680686.

17.H Ahn , J Park , A Gilman-Sachs , J Kwak-Kim . Immunologic characteristics of preeclampsia, a comprehensive review. Am J Reprod Immunol. 2011; 65, 377394.

18.B Schiessl . Inflammatory response in preeclampsia. Mol Aspects Med. 2007; 28, 210219.

25.EF Davis , L Newton , AJ Lewandowski , et al. Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies. Clin Sci (Lond). 2012; 123, 5372.

27.CS Wu , Y Sun , M Vestergaard , et al. Preeclampsia and risk for epilepsy in offspring. Pediatrics. 2008; 122, 10721078.

28.CS Wu , EA Nohr , BH Bech , et al. Health of children born to mothers who had preeclampsia: a population-based cohort study. Am J Obstet Gynecol. 2009; 201, 269.e1269.e10.

29. EKajantie , JGEriksson , COsmond , KThornburg , DJBarker . Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study. Stroke. 2009; 40, 11761180.

31.RM Millis . Epigenetics and hypertension. Curr Hypertens Rep. 2011; 13, 2128.

32.J He , A Zhang , M Fang , et al. Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies. BMC Genomics. 2013; 14, 472.

34.KJ Barrington , A Janvier . The paediatric consequences of assisted reproductive technologies, with special emphasis on multiple pregnancies. Acta Paediatr. 2013; 102, 340348.

36. WEGibbons , MCedars , RBNess , Society for Assisted Reproductive Technologies Writing Group. Toward understanding obstetrical outcome in advanced assisted reproduction: varying sperm, oocyte, and uterine source and diagnosis. Fertil Steril. 2011; 95, 16451649.

37.F Zegers-Hochschild , D Masoli , JE Schwarze , et al. Reproductive performance in oocyte donors and their recipients: comparative analysis from implantation to birth and lactation. Fertil Steril. 2010; 93, 22102215.

38.SA Krieg , MB Henne , LM Westphal . Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies. Fertil Steril. 2008; 90, 6570.

39.V Söderström-Anttila , A Tiitinen , T Foudila , O Hovatta . Obstetric and perinatal outcome after oocyte donation: comparison with in-vitro fertilization pregnancies. Hum Reprod. 1998; 13, 483490.

40.RP Porreco , CL Schoolcraft , WB Schoolcraft . Pregnancy outcome following donor embryo replacement. J Matern Fetal Neonatal Med. 1997; 6, 237240.

42. SKKalra , SJRatcliffe , CCoutifaris , TMolinaro , KTBarnhart . Ovarian stimulation and low birth weight in newborns conceived through in vitro fertilization. Obstet Gynecol. 2011; 118, 863871.

48.LA Schieve , C Ferre , HB Peterson , et al. Perinatal outcome among singleton infants conceived through assisted reproductive technology in the United States. Obstet Gynecol. 2004; 103, 11441153.

49.Society for Assisted Reproductive Technology, American Society for Reproductive Medicine. Assisted reproductive technology in the United States: 1997 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 2000; 74, 641653.

50.Society for Assisted Reproductive Technology, American Society for Reproductive Medicine. Assisted reproductive technology in the United States: 1996 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1999; 71, 798807.

51.Society for Assisted Reproductive Technology, American Society for Reproductive Medicine. Assisted reproductive technology in the United States and Canada: 1995 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1998; 69, 389398.

52.Society for Assisted Reproductive Technology, American Society for Reproductive Medicine. Assisted reproductive technology in the United States and Canada: 1994 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1996; 66, 697705.

54.American Fertility Society & Society of Assisted Reproductive Technology. Assisted reproductive technology in the United States and Canada: 1992 results generated from the American Fertility Society/Society for Assisted Reproductive Technology Registry. Fertil Steril. 1994; 62, 11211128.

56. Medical Research International, Society of Assisted Reproductive Technology, American Fertility Society. In vitro fertilization-embryo transfer (IVF-ET) in the United States: 1990 results from the IVF-ET Registry. Fertil Steril. 1992; 57, 1524.

57.Medical Research International, Society of Assisted Reproductive Technology, American Fertility Society. In vitro fertilization-embryo transfer (IVF-ET) in the United States: 1989 results from the IVF-ET Registry. Fertil Steril. 1991; 55, 1423.

59.Practice Committee of Society for Assisted Reproductive Technology; Practice Committee of American Society for Reproductive Medicine. Fertil Steril. 2012; 97, 835842.

60.SM Nelson , DA Lawlor . Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilisation: a prospective study of 144,018 treatment cycles. PLoS Med. 2011; 8, e1000386.

62.G Sheffer-Mimouni , S Mashiach , J Dor , D Levran , DS Seidman . Factors influencing the obstetric and perinatal outcome after oocyte donation. Hum Reprod. 2002; 17, 26362640.

66.A Kuliev , J Cieslak , Y Verlinsky . Frequency and distribution of chromosome abnormalities in human oocytes. Cytogenet Genome Res. 2005; 111, 193198.

67.M Aye , C Di Giorgio , Mo M De , et al. Assessment of the genotoxicity of three cryoprotectants used for human oocyte vitrification: dimethyl sulfoxide, ethylene glycol and propylene glycol. Food Chem Toxicol. 2010; 48, 19051912.

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