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Metabolomics in the developmental origins of obesity and its cardiometabolic consequences

Published online by Cambridge University Press:  29 January 2015

M. F. Hivert
Affiliation:
Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA
W. Perng*
Affiliation:
Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
S. M. Watkins
Affiliation:
Metabolon Inc., West Sacramento, CA, USA
C. S. Newgard
Affiliation:
Nutrition and Metabolism Center, Duke University of Medicine, Durham, NC, USA
L. C. Kenny
Affiliation:
The Irish Center for Fetal and Neonatal Translational Research, University College Cork, Co. Cork, USA
B. S. Kristal
Affiliation:
Departments of Neurosurgery, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA
M. E. Patti
Affiliation:
Research Division, Joslin Diabetes Center, Boston, MA, USA
E. Isganaitis
Affiliation:
Research Division, Joslin Diabetes Center, Boston, MA, USA
D. L. DeMeo
Affiliation:
Department of Medicine, Channing Division of Network Medicine and Division of Pulmonary and Critical Care, Brigham and Women's Hospital, Boston, MA, USA
E. Oken
Affiliation:
Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
M. W. Gillman
Affiliation:
Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
*
*Address for correspondence: W. Perng, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 3rd floor, Boston 02215, USA. (Email wei.perng@gmail.com)

Abstract

In this review, we discuss the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). We first provide an overview of common techniques and analytical approaches to help interested investigators dive into this relatively novel field. Next, we describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Finally, we review current gaps in knowledge and identify areas where the field of metabolomics is likely to provide insights into mechanisms linked to DOHaD in human populations.

Type
Review
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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Footnotes

Contributed equally as first author

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