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    Roy, Ananya Ettinger, Adrienne S. Hu, Howard Bellinger, David Schwartz, Joel Modali, Rama Wright, Robert O. Palaniappan, Kavitha and Balakrishnan, Kalpana 2013. Effect modification by transferrin C2 polymorphism on lead exposure, hemoglobin levels, and IQ. NeuroToxicology, Vol. 38, p. 17.


    Miodovnik, Amir 2011. Environmental Neurotoxicants and Developing Brain. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine, Vol. 78, Issue. 1, p. 58.


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Effects of early low-level lead exposure on human brain structure, organization and functions

  • K. M. Cecil (a1)
  • DOI: http://dx.doi.org/10.1017/S2040174410000486
  • Published online: 28 September 2010
Abstract

Advanced neuroimaging techniques offer unique insights into how childhood lead exposure impacts the brain. Volumetric magnetic resonance imaging affords anatomical information about the size of global, regional and subcomponent structures within the brain. Diffusion tensor imaging provides information about white matter architecture by quantitatively describing how water molecules diffuse within it. Proton magnetic resonance spectroscopy generates quantitative measures of neuronal, axonal and glial elements via concentration levels of select metabolites. Functional magnetic resonance imaging infers neuronal activity associated with a given task performed. Employing these techniques in the study of the Cincinnati Lead Study, a relatively homogeneous birth cohort longitudinally monitored for over 30 years, one can non-invasively and quantitatively explore how childhood lead exposure is associated with adult brain structure, organization and function. These studies yield important findings how environmental lead exposure impacts human health.

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Corresponding author
*Address for correspondence: K. M. Cecil, PhD, Professor, Radiology, Pediatrics, Neuroscience & Environmental Health, Cincinnati Children’s Hospital Medical Center, Department of Radiology, MLC 5033, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. (Email kim.cecil@chmcc.org)
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Journal of Developmental Origins of Health and Disease
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  • EISSN: 2040-1752
  • URL: /core/journals/journal-of-developmental-origins-of-health-and-disease
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