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    Pinheiro, C.R. Moura, E.G. Manhães, A.C. Fraga, M.C. Claudio-Neto, S. Abreu-Villaça, Y. Oliveira, E. and Lisboa, P.C. 2015. Concurrent maternal and pup postnatal tobacco smoke exposure in Wistar rats changes food preference and dopaminergic reward system parameters in the adult male offspring. Neuroscience, Vol. 301, p. 178.

    Portella, André Krumel and Silveira, Patrícia Pelufo 2014. Neurobehavioral determinants of nutritional security in fetal growth-restricted individuals. Annals of the New York Academy of Sciences, Vol. 1331, Issue. 1, p. 15.

    Bernardi, Juliana Rombaldi Ferreira, Charles Francisco Nunes, Marina da Silva, Clécio Homrich Bosa, Vera Lúcia Silveira, Patrícia Pelufo and Goldani, Marcelo Zubaran 2012. Impact of perinatal different intrauterine environments on child growth and development in the first six months of life - IVAPSA birth cohort: rationale, design, and methods. BMC Pregnancy and Childbirth, Vol. 12, Issue. 1,

  • Journal of Developmental Origins of Health and Disease, Volume 2, Issue 3
  • June 2011, pp. 162-167

Exposure to maternal smoking during fetal life affects food preferences in adulthood independent of the effects of intrauterine growth restriction

  • C. Ayres (a1), P. P. Silveira (a1), M. A. Barbieri (a2), A. K. Portella (a1), H. Bettiol (a2), M. Agranonik (a1), A. A. Silva (a3) and M. Z. Goldani (a1)
  • DOI:
  • Published online: 01 June 2011

Experimental animal studies have shown that nicotine exposure during gestation alters the expression of fetal hypothalamic neuropeptides involved in the control of appetite. We aimed to determine whether the exposure to maternal smoking during gestation in humans is associated with an altered feeding behavior of the adult offspring. A longitudinal prospective cohort study was conducted including all births from Ribeirão Preto (São Paulo, Brazil) between 1978 and 1979. At 24 years of age, a representative random sample was re-evaluated and divided into groups exposed (n = 424) or not (n = 1586) to maternal smoking during gestation. Feeding behavior was analyzed using a food frequency questionnaire. Covariance analysis was used for continuous data and the χ2 test for categorical data. Results were adjusted for birth weight ratio, body mass index, gender, physical activity and smoking, as well as maternal and subjects’ schooling. Individuals exposed to maternal smoking during gestation ate more carbohydrates than proteins (as per the carbohydrate-to-protein ratio) than non-exposed individuals. There were no differences in the consumption of the macronutrients themselves. We propose that this adverse fetal life event programs the individual's physiology and metabolism persistently, leading to an altered feeding behavior that could contribute to the development of chronic diseases in the long term.

Corresponding author
*Address for correspondence: P. P. Silveira, Departamento de Pediatria, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul. Ramiro Barcelos, 2350, Largo Eduardo Zaccaro Faraco, 90035-903 Porto Alegre, Brazil. (Email
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3.KV Blake , LC Gurrin , SF Evans , Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood. Early Hum Dev. 2000; 2, 137147.

4.A Thapar , T Fowler , F Rice . Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Am J Psychiatry. 2003; 160, 19851989.

5.NA Sowan , ML Stember . Effect of maternal prenatal smoking on infant growth and development of obesity. J Perinat Educ. 2000; 3, 2229.

6.M Wideroe , T Vik , G Jacobsen , LS Bakketeig . Does maternal smoking during pregnancy cause childhood overweight? Paediatr Perinat Epidemiol. 2003; 2, 171179.

8.MA Barbieri , AK Portella , PP Silveira , Severe intrauterine growth restriction is associated with higher spontaneous carbohydrate intake in young women. Pediatr Res. 2009; 2, 215220.

9.NE Grunberg . The effects of nicotine and cigarette smoking on food consumption and taste preferences. Addict Behav. 1982; 4, 317331.

10.D Albanes , DY Jones , MS Micozzi , ME Mattson . Associations between smoking and body weight in the US population: analysis of NHANES II. Am J Public Health. 1987; 4, 439444.

12.ZAR Oliveira , H Bettiol , MA Barbieri , MRP Gutierrez , VM Azenha . Factors associated with infant and adolescence mortality. J Epidemiol Community Health. 2004; 58, 107108.

13.MA Barbieri , H Bettiol , AA Silva . Health in early adulthood: the contribution of the 1978/79 Ribeirao Preto birth cohort. Braz J Med Biol Res. 2006; 39, 10411055.

14.MZ Goldani , MA Barbieri , AA Silva , H Bettiol . Trends in prenatal care use and low birthweight in southeast Brazil. Am J Public Health. 2004; 94, 13661371.

15.LY Tomita , MA Cardoso . Assessment of the food list and serving size of a food frequency questionnaire in an adult population. Cad Saude Publica. 2002; 18, 17471756.

16.MC Molina , H Bettiol , MA Barbieri , Food consumption by young adults living in Ribeirão Preto, SP, 2002/2004. Braz J Med Biol Res. 2007; 40, 12571266.

18.PC Hallal , CG Victora . Reliability and validity of the international physical activity questionnaire (IPAQ). Med Sci Sports Exerc. 2004; 3, 556.

20.DP Keys , F Fidanza , MJ Kcarvonen , N Kimura , HK Taylor . Indices of relative weight and obesity. J Chron Dis. 1972; 25, 329343.

21.MS Kramer , R Platt , H Yang , H McNamara , RH Usher . Are all growth-restricted newborns created equal(ly)? Pediatrics. 1999; 103, 599602.

24.N Pecoraro , F Reyes , F Gomez , A Bhargava , MF Dallman . Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress. Endocrinology. 2004; 145, 37543762.

27.C Power , BJ Jefferis . Fetal environment and subsequent obesity: a study of maternal smoking. Int J Epidemiol. 2002; 2, 413419.

28.RM Franke , M Park , JD Belluzzi , FM Leslie . Prenatal nicotine exposure changes natural and drug-induced reinforcement in adolescent male rats. Eur J Neurosci. 2008; 11, 29522961.

29.KL Law , LR Stroud , LL LaGasse , Smoking during pregnancy and newborn neurobehavior. Pediatrics. 2003; 111, 13181323.

30.SL Buka , ED Shenassa , R Niaura . Elevated risk of tobacco dependence among offspring of mothers who smoked during pregnancy: a 30-year prospective study. Am J Psychiatry. 2003; 160, 19781984.

31.NM Avena , KA Long , BG Hoebel . Sugar-dependent rats show enhanced responding for sugar after abstinence: evidence of a sugar deprivation effect. Physiol Behav. 2005; 84, 359362.

32.C Cadoni , V Valentini , G Di Chiara . Behavioral sensitization to delta 9-tetrahydrocannabinol and cross-sensitization with morphine: differential changes in accumbal shell and core dopamine transmission. J Neurochem. 2008; 4, 15861593.

33.J Le Merrer , DN Stephens . Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake. J Neurosci. 2006; 27, 71637171.

35.A Myrsten , A Elaerot , B Ednren . Effects of abstinence from tobacco smoking on physiological and psychological arousal levels-in habitual smokers. Psychosomatic Med. 1977; 39, 2538.

37.NI Larson , DR Neumark-Sztainer , LJ Harnack , Fruit and vegetable intake correlates during the transition to young adulthood. Am J Prev Med. 2008; 35, 3337.

39.DK Layman , EM Evans , D Erickson , A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults. J Nutr. 2009; 139, 514521.

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Journal of Developmental Origins of Health and Disease
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  • EISSN: 2040-1752
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