Skip to main content
×
Home
    • Aa
    • Aa

In rats gestational iron deficiency does not change body fat or hepatic mitochondria in the aged offspring

  • W. D. Rees (a1), S. M. Hay (a1), H. E. Hayes (a1), C. Birgovan (a1) and H. J. McArdle (a1)...
Abstract

Mitochondrial dysfunction and resulting changes in adiposity have been observed in the offspring of animals fed a high fat (HF) diet. As iron is an important component of the mitochondria, we have studied the offspring of female rats fed complete (Con) or iron-deficient (FeD) rations for the duration of gestation to test for similar effects. The FeD offspring were ~12% smaller at weaning and remained so because of a persistent reduction in lean tissue mass. The offspring were fed a complete (stock) diet until 52 weeks of age after which some animals from each litter were fed a HF diet for a further 12 weeks. The HF diet increased body fat when compared with animals fed the stock diet, however, prenatal iron deficiency did not change the ratio of fat:lean in either the stock or HF diet groups. The HF diet caused triglyceride to accumulate in the liver, however, there was no effect of prenatal iron deficiency. The activity of the mitochondrial electron transport complexes was similar in all groups including those challenged with a HF diet. HF feeding increased the number of copies of mitochondrial DNA and the prevalence of the D-loop mutation, however, neither parameter was affected by prenatal iron deficiency. This study shows that the effects of prenatal iron deficiency differ from other models in that there is no persistent effect on hepatic mitochondria in aged animals exposed to an increased metabolic load.

Copyright
Corresponding author
*Address for correspondence: W. D. Rees, Rowett Institute of Nutrition and Health, University of Aberdeen , Foresterhill, Aberdeen AB21 9SB, UK. (Email w.rees@abdn.ac.uk)
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Developmental Origins of Health and Disease
  • ISSN: 2040-1744
  • EISSN: 2040-1752
  • URL: /core/journals/journal-of-developmental-origins-of-health-and-disease
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 2
Total number of PDF views: 5 *
Loading metrics...

Abstract views

Total abstract views: 77 *
Loading metrics...

* Views captured on Cambridge Core between 5th September 2017 - 17th October 2017. This data will be updated every 24 hours.