1.Edwards, LJ, McMillen, IC. Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2002; 283, R669–R679.
2.Kwong, WY, Wild, AE, Roberts, P, Willis, AC, Fleming, TP. Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development. 2000; 127, 4195–4202.
3.Gardner, DS, Pearce, S, Dandrea, J, et al. Peri-implantation undernutrition programs blunted angiotensin II evoked baroreflex responses in young adult sheep. Hypertension. 2004; 43, 1290–1296.
4.MacLaughlin, SM, Walker, SK, Kleemann, DO, et al. Impact of periconceptional undernutrition on adrenal growth and adrenal insulin-like growth factor and steroidogenic enzyme expression in the sheep fetus during early pregnancy. Endocrinology. 2007; 148, 1911–1920.
5.Roseboom, T, de Rooij, S, Painter, R. The Dutch famine and its long-term consequences for adult health. Earl Hum Dev. 2006; 82, 485–491.
6.Watkins, AJ, Wilkins, A, Cunningham, C, et al. Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. J Physiol. 2008; 586, 2231–2244.
7.Roseboom, TJ, van der Meulen, JH, Ravelli, AC, et al. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Twin Res. 2001; 4, 293–298.
8.Roseboom, TJ, van der Meulen, JHP, Osmond, C, et al. Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45. Heart. 2000; 84, 595–598.
9.Roseboom, TJ, van der Meulen, JHP, Osmond, C, et al. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr. 2000; 72, 1101–1106.
10.Painter, RC, de Rooij, SR, Bossuyt, PM, et al. Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am J Clin Nutr. 2006; 84, 322–327.
11.Levy, D, Garrison, RJ, Savage, DD, Kannel, WB, Castelli, WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990; 322, 1561–1566.
12.Mandavia, CH, Aroor, AR, DeMarco, VG, Sowers, JR. Molecular and metabolic mechanisms of cardiac dysfunction in diabetes. Life Sci. 2012; 92, 601–608.
13.Brooks, G, Poolman, RA, Li, J-M. Arresting developments in the cardiac myocyte cell cycle: role of cyclin-dependent kinase inhibitors. Cardiovasc Res. 1998; 39, 301–311.
14.Cohick, WS, Clemmons, DR. The insulin-like growth factors. Annu Rev Physiol. 1993; 55, 131–153.
15.Sherr, CJ. G1 phase progression: cycling on cue. Cell. 1994; 79, 551–555.
16.Sundgren, NC, Giraud, GD, Schultz, JM, et al. Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes. Am J Physiol Regul Integr Comp Physiol. 2003; 285, R1481–R1489.
17.Kornfeld, S. Structure and function of the mannose 6-phosphate/insulin like growth factor II receptors. Annu Rev Biochem. 1992; 61, 307–330.
18.Chu, CH, Tzang, BS, Chen, LM, et al. IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells. J Endocrinol. 2008; 197, 381–390.
19.Wang, KCW, Brooks, DA, Thornburg, KL, Morrison, JL. Activation of IGF-2R stimulates cardiomyocyte hypertrophy in the late gestation sheep fetus. J Physiol. 2012; 590, 5425–5437.
20.Dietz, R, Haass, M, Kübler, W. Atrial natriuretic factor. Its possible role in hypertension and congestive heart failure. Am J Hypertens. 1989; 2, 29S–33S.
21.Nishikimi, T, Maeda, N, Matsuoka, H. The role of natriuretic peptides in cardioprotection. Cardiovasc Res. 2006; 69, 318–328.
22.Pause, A, Belsham, GJ, Gingras, A-C, et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature. 1994; 371, 762–767.
23.Gingras, AC, Kennedy, SG, O'Leary, MA, Sonenberg, N, Hay, N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 1998; 12, 502–513.
24.Kang, S, Chemaly, ER, Hajjar, RJ, Lebeche, D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011; 286, 18465–18473.
25.Brown, EJ, Beal, PA, Keith, CT, et al. Control of P70 S6 kinase by kinase-activity of FRAP in-vivo. Nature. 1995; 377, 441–446.
26.Kawasome, H, Papst, P, Webb, S, et al. Targeted disruption of p70s6k defines its role in protein synthesis and rapamycin sensitivity. Proc Natl Acad Sci U S A. 1998; 95, 5033–5038.
27.Dong, F, Ford, SP, Fang, CX, et al. Maternal nutrient restriction during early to mid gestation up-regulates cardiac insulin-like growth factor (IGF) receptors associated with enlarged ventricular size in fetal sheep. Growth Horm IGF Res. 2005; 15, 291–299.
28.Bertram, C, Khan, O, Ohri, S, et al. Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic–pituitary–adrenal function. J Physiol. 2008; 586, 2217–2229.
29.Lopaschuk, GD, Jaswal, JS. Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. J Cardiovasc Pharmacol. 2010; 56, 130–140.
30.Hay, WWJ. Placental transport of nutrients to the fetus. Horm Res. 1994; 42, 215–222.
31.Taniguchi, CM, Emanuelli, B, Kahn, CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006; 7, 85–96.
32.Pineiro, R, Iglesias, MJ, Gallego, R, et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett. 2005; 579, 5163–5169.
33.Yamauchi, T, Kamon, J, Ito, Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003; 423, 762–769.
34.Park, SH, Gammon, SR, Knippers, JD, et al. Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol. 2002; 92, 2475–2482.
35.Lopaschuk, GD, Gamble, J. The 1993 Merck Frosst Award. Acetyl-CoA carboxylase: an important regulator of fatty acid oxidation in the heart. Can J Physiol Pharmacol. 1994; 72, 1101–1109.
36.McGarry, JD. The mitochondrial carnitine palmitoyltransferase system: its broadening role in fuel homoeostasis and new insights into its molecular features. Biochem Soc Trans. 1995; 23, 321–324.
37.Kadowaki, T, Yamauchi, T. Adiponectin and adiponectin receptors. Endocr Rev. 2005; 26, 439–451.
38.Wu, P, Sato, J, Zhao, Y, et al. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J. 1998; 329, 197–201.
39.Sugden, MC, Holness, MJ. Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases. Arch Physiol Biochem. 2006; 112, 139–149.
40.Burrell, JH, Boyn, AM, Kumarasamy, V, et al. Growth and maturation of cardiac myocytes in fetal sheep in the second half of gestation. Anat Rec A Discov Mol Cell Evol Biol. 2003; 274A, 952–961.
41.Jonker, SS, Zhang, L, Louey, S, et al. Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart. J Appl Physiol. 2007; 102, 1130–1142.
42.Watkins, AJ, Lucas, ES, Wilkins, A, Cagampang, FRA, Fleming, TP. Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age. PLoS One. 2011; 6, e28745.
43.Roseboom, TJ, Painter, RC, van Abeelen, AFM, Veenendaal, MVE, de Rooij, SR. Hungry in the womb: what are the consequences? Lessons from the Dutch famine. Maturitas. 2011; 70, 141–145.
44.Rutter, MK, Parise, H, Benjamin, EJ, et al. Impact of glucose intolerance and insulin resistance on cardiac structure and function. Circulation. 2003; 107, 448–454.
45.Mora, A, Sakamoto, K, McManus, EJ, Alessi, DR. Role of the PDK1–PKB–GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart. FEBS Lett. 2005; 579, 3632–3638.
46.Stride, N, Larsen, S, Treebak, JT, et al. 5′-AMP activated protein kinase is involved in the regulation of myocardial β-oxidative capacity in mice. Front Physiol. 2012; 3, article 33.
47.Turdi, S, Kandadi, MR, Zhao, J, et al. Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Cardiol. 2011; 50, 712–722.
48.Meurs, K, Lahmers, S, Keene, B, et al. A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Hum Genet. 2012; 131, 1319–1325.
49.Lopes, R, Solter, PF, Sisson, DD, Oyama, MA, Prosek, R. Characterization of canine mitochondrial protein expression in natural and induced forms of idiopathic dilated cardiomyopathy. Am J Vet Res. 2006; 67, 963–970.
50.Samovski, D, Su, X, Xu, Y, Abumrad, NA, Stahl, PD. Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase. J Lipid Res. 2012; 53, 709–717.
51.Ginion, A, Auquier, J, Benton, CR, et al. Inhibition of the mTOR/p70S6 K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake. Am J Physiol Heart Circ Physiol. 2011; 301, H469–H477.
52.Waterland, RA, Michels, KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007; 27, 363–388.
53.Guay, C, Roggli, E, Nesca, V, Jacovetti, C, Regazzi, R. Diabetes mellitus, a microRNA-related disease? Transl Res. 2011; 157, 253–264.
54.Rottiers, V, Najafi-Shoushtari, SH, Kristo, F, et al. MicroRNAs in metabolism and metabolic diseases. Cold Spring Harb Symp Quant Biol. 2011; 76, 225–233.
55.Bartel, DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116, 281–297.