Skip to main content Accesibility Help
×
×
Home

Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood

  • P. M. Mullin (a1), A. Bray (a2), F. Schoenberg (a2), K. W. MacGibbon (a3), R. Romero (a4), T. M. Goodwin (a1) and M. S. Fejzo (a1) (a5)...
Abstract

Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, is characterized by long-term maternal stress, undernutrition and dehydration. While maternal stress and malnutrition of pregnancy are linked to poor neonatal outcome and associated with poor adult health, long-term outcome of fetal exposure to HG has never been explored. The purpose of this study is to determine whether long-term emotional and behavioral diagnoses may be associated with fetal exposure to HG. Emotional and behavioral diagnoses of adults born of a pregnancy complicated by HG were compared to diagnoses from non-exposed controls. Offspring exposed to HG in utero were significantly more likely to have a psychological and behavioral disorder (OR = 3.6, P < 0.0001) with diagnoses primarily of depression, bipolar disorder and anxiety. In utero exposure to HG may lead to increased risks of psychological and behavioral disorders in the offspring.

Copyright
Corresponding author
*Address for correspondence: Dr M. S. Fejzo, Ph.D., 5535 MRL Building. 675 Charles E Young Dr South, LA, CA 90095, USA. (Email mfejzo@mednet.ucla.edu)
Footnotes
Hide All
a

These authors contributed equally.

Footnotes
References
Hide All
1.Wier, LM, Levit, K, Stranges, E, et al. . HCUP Facts and Figures: Statistics on Hospital-based Care in the United States, 2008, 2010. Agency for Healthcare Research and Quality, Rockville, MD, Retrieved from http://www.hcup-us.ahrq.gov/reports.jsp.
2.Verberg, MF, Gillott, DJ, Al-Fardan, N, Grudzinskas, JG. Hyperemesis gravidarum, a literature review. Hum Reprod Update. 2005; 11, 527539.
3.Kallen, B. Hyperemesis during pregnancy and delivery outcome: a registry study. Eur J Obstet Gynecol Reprod Biol. 1987; 26, 291302.
4.Zhang, J, Cai, WW. Severe vomiting during pregnancy: antenatal correlates and fetal outcomes. Epidemiology. 1991; 2, 454457.
5.Chiossi, G, Neri, I, Cavazutti, M, Basso, G, Fucchinetti, F. HG complicated by Wernicke's encephalopathy: background, case report and review of the literature. Obstet Gynecol Surv. 2006; 61, 255268.
6.Bailit, JL. HG: epidemiologic findings from a large cohort. Am J Obstet Gynecol. 2005; 193, 811814.
7.Fairweather, DVI. Nausea and vomiting in pregnancy. Am J Obstet Gynecol. 1968; 102, 135175.
8.Goodwin, TM. Hyperemesis gravidarum. Clin Obstet Gynecol. 1998; 41, 597605.
9.Fejzo, MS, Poursharif, B, Korst, LM, et al. . Symptoms and pregnancy outcomes associated with extreme weight loss among women with HG. J Womens Health. 2009; 18, 19811987.
10.Gazmararian, JA, Petersen, R, Jamieson, DJ, et al. . Hospitalizations during pregnancy among managed care enrollees. Obstet Gynecol. 2002; 100, 94100.
11.Henderson, BE, Benton, B, Jing, J, Yu, MC, Pike, MC. Risk factors for cancer of the testis in young men. Int J Cancer. 1979; 15, 598602.
12.Erlandsson, G, Lambe, M, Cnattingius, S, Ekbom, A. Hyperemesis gravidarum and subsequent breast cancer risk. Br J Cancer. 2002; 21, 974976.
13.Mulder, EJ, Robles de Medina, PG, Huizink, AC, et al. . Prenatal maternal stress: effects on pregnancy and the (unborn) child. Early Hum Dev. 2002; 70, 314.
14.Lazinski, M, Shea, A, Steiner, M. Effects of maternal prenatal stress on offspring development: a commentary. Arch Wom Ment Health. 2008; 11, 363375.
15.Painter, RC, Roseboom, TJ, Bleker, OP. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol. 2005; 20, 345352.
16.de Rooij, SR, Wouters, H, Yonker, JE, Painter, RC, Roseboom, TJ. Prenatal undernutrition and cognitive function in late adulthood. Proc Natl Acad Sci U S A. 2010; 107, 1688116886.
17.Ross, MG, Desai, M. Gestational programming: population survival effects of drought and famine during pregnancy. Am J Physiol Regul Integr Comp Physiol. 2005; 288, 2533.
18.Zhang, Y, Cantor, RM, Macgibbon, K, et al. . Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol. 2010; 204, 230.e1230.e7.
19.Martin, RP, Wisenbaker, J, Huttunen, MO. Nausea during pregnancy: relation to early childhood temperament and behavior problems at twelve years. J Abnl Child Psych. 1999; 27, 323329.
20.Nulman, I, Rovet, J, Barrera, M, et al. . Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin. J Pediatr. 2009; 155, 4550.
21.Pirimoglu, ZM, Guzelmeric, K, Alpay, B, et al. . Psychological factors of hyperemesis gravidarum by using the SCL-90-R questionnaire. Clin Exp Obstet Gynecol. 2010; 37, 5659.
22.Tan, PC, Vani, S, Lim, BK, Omar, SZ. Anxiety and depression in hyperemesis gravidarum: prevalence, risk factors and correlation with clinical severity. Eur J Obstet Gynecol Reprod Biol. 2010; 149, 153158.
23.Chiossi, G, Neri, I, Cavazzuti, M, Basso, G, Facchinetti, F. Hyperemesis gravidarum complicated by Wernicke encephalopathy: background, case report, and review of the literature. Obstet Gynecol Surv. 2006; 61, 255268.
24.Eventov-Friedman, S, Klinger, G, Shinwell, ES. Third trimester fetal intracranial hemorrhage owing to vitamin K deficiency associated with hyperemesis gravidarum. J Pediatr Hematol Oncol. 2009; 31, 985988.
25.Black, MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull. 2008; 29(Suppl. 2), S126S131.
26.Harms, LR, Eyles, DW, McGrath, JJ, Mackay-Sim, A, Burne, TH. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice. Behav Brain Res. 2008; 187, 343350.
27.Calza, A, Sogliano, C, Santoru, F, et al. . Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs. J Neurochem. 2010; 113, 12851295.
28.Demir, B, Erel, CT, Haberal, A, et al. . Adjusted leptin level (ALL) is a predictor for hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2006; 124, 193196.
29.Aka, N, Atalay, S, Sayharman, S, et al. . Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum. Aust N Z J Obstet Gynaecol. 2006; 46, 274277.
30.Fraga-Marques, MC, Moura, EG, Claudio-Neto, S, et al. . Neonatal hyperleptinaemia programmes anxiety-like and novelty seeking behaviours but not memory/learning in adult rats. Horm Behav. 2009; 55, 272279.
31.Weaver, IC. Shaping adult phenotypes through early life environments. Birth Defects Res C Embryo Today. 2009; 87, 314326.
32.Coetzee, RL, Cormack, B, Sadler, L, Bloomfield, FH. Pregnancy and neonatal outcomes following hyperemesis gravidarum. J Dev Orig Health Dis. 2011; 2, 8188.
33.Roseboom, TJ, Ravelli, AC, van der Post, JA, Painter, RC. Maternal characteristics largely explain poor pregnancy outcome after hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2011; 156, 5659.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Developmental Origins of Health and Disease
  • ISSN: 2040-1744
  • EISSN: 2040-1752
  • URL: /core/journals/journal-of-developmental-origins-of-health-and-disease
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed