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Street drug use during pregnancy: potential programming effects on preschool wheeze

  • M. E. Alton (a1), S. C. Tough (a2), P. J. Mandhane (a3) and A. L. Kozyrskyj (a3)
Abstract

Street drug use during pregnancy is detrimental to fetal development. Although the prevalence of wheeze is high in offspring of substance-abusing mothers, nothing is known about the role of street drug use during pregnancy in its development. We investigated the impact of maternal street drug use and distress during pregnancy on the development of wheeze and allergy in preschool children. Questionnaire data were accessed from the Community Perinatal Care trial of 791 mother–child pairs in Calgary, Alberta. Using logistic regression, the association between maternal substance use and distress during pregnancy, and wheeze and allergy at age 3 years was determined in boys and girls. After adjusting for alcohol use during pregnancy, pre- and postnatal tobacco use, preterm birth, duration of exclusive breastfeeding, daycare attendance and maternal socioeconomic status, maternal street drug use during pregnancy [odds ratio (OR): 5.02, 95% confidence interval (CI): 1.30–19.4] and severe maternal distress during pregnancy (OR: 5.79, 95% CI: 1.25–26.8) were associated with wheeze in girls. In boys, an independent association was found between severe distress during pregnancy (OR: 3.85, 95% CI: 1.11–13.3) and allergies, but there was no association with maternal street drug use. In conclusion, we found an association between maternal street drug use and wheeze in preschool girls that could not be accounted for by maternal distress, smoking or alcohol use during pregnancy. Prenatal programming effects of street drugs may explain this association.

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Corresponding author
*Address for correspondence: Dr A. L. Kozyrskyj, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, 3-527 Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, AB, T6G 1C9 Canada. (Email kozyrsky@ualberta.ca)
References
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1.Substance Abuse and Mental Health Services Administration. Results from the 2007 National Survey on Drug Use and Health: National Findings, NSDUH Series H-34, 2008. Office of Applied Studies: Rockville, MD, USA.
2.Tough SC, Johnston DW, Siever JE, et al. Does supplementary prenatal nursing and home visitation support improve resource use in a universal health care system? A randomized controlled trial in Canada. Birth. 2006; 33, 183194.
3.Moore DG, Turner JD, Parrott AC, et al. During pregnancy, recreational drug-using women stop taking ecstasy (3,4-methylenedioxy-N-methylamphetamine) and reduce alcohol consumption, but continue to smoke tobacco and cannabis: initial findings from the development and infancy study. J Psychopharmacol. 2010; 24, 14031410.
4.Pinto SM, Dodd S, Walkinshaw SA, et al. Substance abuse during pregnancy: effect on pregnancy outcomes. Eur J Obstet Gynecol Reprod Biol. 2010; 150, 137141.
5.Kelly JJ, Davis PG, Henschke PN. The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre. J Paediatr Child Health. 2000; 36, 262264.
6.Bandstra ES, Morrow CE, Mansoor E, Accornero VH. Prenatal drug exposure: infant and toddler outcomes. J Addict Dis. 2010; 29, 245258.
7.Streissguth AP, Barr HM, Martin DC. Offspring effects and pregnancy complications related to self-reported maternal alcohol use. Dev Pharmacol Ther. 1982; 5, 2132.
8.Lester BM, Tronick EZ, Lagasse L, et al. The maternal lifestyle study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants. Pediatrics. 2002; 110, 11821192.
9.Morrow CE, Bandstra ES, Anthony JC, et al. Influence of prenatal cocaine exposure on early language development: longitudinal findings from four months to three years of age. J Dev Behav Pediatr. 2003; 24, 3950.
10.Salisbury AL, Ponder KL, Padbury JF, Lester BM. Fetal effects of psychoactive drugs. Clin Perinatol. 2009; 36, 595619.
11.Fried PA, Watkinson B, Gray R. Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marijuana. Neurotoxicol Teratol. 2003; 25, 427436.
12.Goldschmidt L, Day NL, Richardson GA. Effects of prenatal marijuana exposure on child behavior problems at age 10. Neurotoxicol Teratol. 2000; 22, 325336.
13.Conners NA, Bradley RH, Mansell LW, et al. Children of mothers with serious substance abuse problems: an accumulation of risks. Am J Drug Alcohol Abuse. 2004; 30, 85100.
14.Schaubel D, Johansen H, Dutta M, et al. Neonatal characteristics as risk factors for preschool asthma. J Asthma. 1996; 33, 255264.
15.Lester BM, LaGasse LL. Children of addicted women. J Addict Dis. 2010; 29, 259276.
16.Karlix JL, Behnke M, vis-Eyler F, et al. Cocaine suppresses fetal immune system. Pediatr Res. 1998; 44, 4346.
17.Basu S, Dittel BN. Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease. Immunol Res. 2011; 51, 2638.
18.Fride E. Multiple roles for the endocannabinoid system during the earliest stages of life: pre- and postnatal development. J Neuroendocrinol. 2008; 20(Suppl 1), 7581.
19.Viveros MP, Marco EM, Lopez-Gallardo M, Garcia-Segura LM, Wagner EJ. Framework for sex differences in adolescent neurobiology: a focus on cannabinoids. Neurosci Biobehav Rev. 2011; 35, 17401751.
20.Viveros MP, Marco EM, Lopez-Gallardo M, Garcia-Segura LM, Wagner EJ. Framework for sex differences in adolescent neurobiology: a focus on cannabinoids. Neurosci Biobehav Rev. 2011; 35, 17401751.
21.Simmons LA, Havens JR, Whiting JB, Holz JL, Bada H. Illicit drug use among women with children in the United States: 2002–2003. Ann Epidemiol. 2009; 19, 187193.
22.Wright RJ. Prenatal maternal stress and early caregiving experiences: implications for childhood asthma risk. Paediatr Perinat Epidemiol. 2007; 21(S3), 814.
23.Leung E, Tasker SL, Atkinson L, et al. Perceived maternal stress during pregnancy and its relation to infant stress reactivity at 2 days and 10 months of postnatal life. Clin Pediatr (Phila). 2010; 49, 158165.
24.Wood RA, Bloomberg GR, Kattan M, et al. Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study). J Allergy Clin Immunol. 2011; 127, 913919.
25.Wright RJ. Perinatal stress and early life programming of lung structure and function. Biol Psychol. 2010; 84, 4656.
26.Pajulo M, Savonlahti E, Sourander A, Helenius H, Piha J. Antenatal depression, substance dependency and social support. J Affect Disord. 2001; 65, 917.
27.Salisbury AL, Lester BM, Seifer R, et al. Prenatal cocaine use and maternal depression: effects on infant neurobehavior. Neurotoxicol Teratol. 2007; 29, 331340.
28.Clifton VL. Review: sex and the human placenta: mediating differential strategies of fetal growth and survival. Placenta. 2010; 31(Suppl), S33S39.
29.Kajantie E, Phillips DI. The effects of sex and hormonal status on the physiological response to acute psychosocial stress. Psychoneuroendocrinology. 2006; 31, 151178.
30.Funkhouser AW, Butz AM, Feng TI, McCaul ME, Rosenstein BJ. Prenatal care and drug use in pregnant women. Drug Alcohol Depend. 1993; 33, 19.
31.Heil SH, Jones HE, Arria A, et al. Unintended pregnancy in opioid-abusing women. J Subst Abuse Treat. 2011; 40, 199202.
32.Holtrop JS, Meghea C, Raffo JE, et al. Smoking among pregnant women with Medicaid insurance: are mental health factors related? Matern Child Health J. 2010; 14, 971977.
33.Erickson AC, Arbour LT. Heavy smoking during pregnancy as a marker for other risk factors of adverse birth outcomes: a population-based study in British Columbia, Canada. BMC Public Health. 2012; 12, 102.
34.Tough SC, Siever JE, Leew S, et al. Maternal mental health predicts risk of developmental problems at 3 years of age: follow up of a community based trial. BMC Pregnancy and Childbirth. 2008; 8, 16.
35.Kellner R. A symptom questionnaire. J Clin Psychiatry. 1987; 48, 268274.
36.Doyle LW, Anderson PJ. Pulmonary and neurological follow-up of extremely preterm infants. Neonatology. 2010; 97, 388394.
37.Martinez FD, Wright AL, Taussig LM, et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995; 332, 133138.
38.Saglani S, Bush A. Asthma in preschool children: the next challenge. Curr Opin Allergy Clin Immunol. 2009; 9, 141145.
39.Kuehni CE, Davis A, Brooke AM, Silverman M. Are all wheezing disorders in very young (preschool) children increasing in prevalence? Lancet. 2001; 357, 18211825.
40.Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med. 2000; 162(Pt 1), 14031406.
41.Wright RJ, Cohen S, Carey V, Weiss ST, Gold DR. Parental stress as a predictor of wheezing in infancy: a prospective birth-cohort study. Am J Respir Crit Care Med. 2002; 165, 358365.
42.Midodzi WK, Rowe BH, Majaesic CM, Saunders LD, Senthilselvan A. Early life factors associated with incidence of physician-diagnosed asthma in preschool children: results from the Canadian early childhood development cohort study. J Asthma. 2010; 47, 713.
43.Alati R, Al MA, O'Callaghan M, Najman JM, Williams GM. In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology. 2006; 17, 138144.
44.Lannero E, Wickman M, Pershagen G, Nordvall L. Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE). Respir Res. 2006; 7, 3.
45.Jaakkola JJ, Ahmed P, Ieromnimon A, et al. Preterm delivery and asthma: a systematic review and meta-analysis. J Allergy Clin Immunol. 2006; 118, 823830.
46.Devereux G. Session 1: Allergic disease: nutrition as a potential determinant of asthma. Proc Nutr Soc. 2010; 69, 110.
47.Kozyrskyj AL, Kendall GE, Jacoby P, Sly PD, Zubrick SR. Association between socioeconomic status and the development of asthma: analyses of income trajectories. Am J Public Health. 2010; 100, 540546.
48.Akinbami L. The state of childhood asthma, United States, 1980–2005. Adv Data. 2006; 381, 124.
49.Kozyrskyj AL, Mai XM, McGrath P, et al. Continued exposure to maternal distress in early life is associated with an increased risk of childhood asthma. Am J Respir Crit Care Med. 2008; 177, 142147.
50.Cookson H, Granell R, Joinson C, Ben-Shlomo Y, Henderson AJ. Mothers’ anxiety during pregnancy is associated with asthma in their children. J Allergy Clin Immunol. 2009; 123, 847853.
51.Liu CA, Wang CL, Chuang H, et al. Prenatal prediction of infant atopy by maternal but not paternal total IgE levels. J Allergy Clin Immunol. 2003; 112, 899904.
52.Seckl JR, Holmes MC. Mechanisms of disease: glucocorticoids, their placental metabolism and fetal ‘programming’ of adult pathophysiology. Nat Clin Pract Endocrinol Metab. 2007; 3, 479488.
53.Zaichkin J, Houston RF. The drug-exposed mother and infant: a regional center experience. Neonatal Netw. 1993; 12, 4149.
54.Patelarou E, Chochlidaki M, Vivilaki V, Brokalaki H. Is there a link between wheezing in early childhood and adverse birth outcomes? A systematic review. Int J Environ Res Public Health. 2009; 6, 27522761.
55.Erkkola M, Kaila M, Nwaru BI, et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy. 2009; 39, 875882.
56.Li W, Green TJ, Innis SM, et al. Suboptimal vitamin D levels in pregnant women despite supplement use. Can J Public Health. 2011; 102, 308312.
57.Daley M, Shepard DS, Bury-Maynard D. Changes in quality of life for pregnant women in substance user treatment: developing a quality of life index for the addictions. Subst Use Misuse. 2005; 40, 375394.
58.Grella CE. Services for perinatal women with substance abuse and mental health disorders: the unmet need. J Psychoactive Drugs. 1997; 29, 6778.
59.Chen E, Martin AD, Matthews KA. Understanding health disparities: the role of race and socioeconomic status in children's health. Am J Public Health. 2006; 96, 702708.
60.Viveros MP, Marco EM, Lopez-Gallardo M, Garcia-Segura LM, Wagner EJ. Framework for sex differences in adolescent neurobiology: a focus on cannabinoids. Neurosci Biobehav Rev. 2011; 35, 17401751.
61.Lester BM, LaGasse LL. Children of addicted women. J Addict Dis. 2010; 29, 259276.
62.Viveros MP, Marco EM, Lopez-Gallardo M, Garcia-Segura LM, Wagner EJ. Framework for sex differences in adolescent neurobiology: a focus on cannabinoids. Neurosci Biobehav Rev. 2011; 35, 17401751.
63.Dow-Edwards D. Sex differences in the effects of cocaine abuse across the life span. Physiol Behav. 2010; 100, 208215.
64.Lowe AJ, Carlin JB, Bennett CM, et al. Do boys do the atopic march while girls dawdle? J Allergy Clin Immunol. 2008; 121, 11901195.
65.Becklake MR, Kauffmann F. Gender differences in airway behaviour over the human life span. Thorax. 1999; 54, 11191138.
66.Lester BM, Padbury JF. Third pathophysiology of prenatal cocaine exposure. Dev Neurosci. 2009; 31, 2335.
67.Trezza V, Cuomo V, Vanderschuren LJ. Cannabis and the developing brain: insights from behavior. Eur J Pharmacol. 2008; 585, 441452.
68.Bavis RW, Mitchell GS. Long-term effects of the perinatal environment on respiratory control. J Appl Physiol. 2008; 104, 12201229.
69.Fava GA, Kellner R, Perini GI, et al. Italian validation of the Symptom Rating Test (SRT) and Symptom Questionnaire (SQ). Can J Psychiatry. 1983; 28, 117123.
70.Bull MJ, Luo D, Maruyama G. Symptom Questionnaire anxiety and depression scales: reliability and validity. J Nurs Meas. 1994; 2, 2536.
71.Tough SC, Siever JD, Johnston DW. Retaining women in a prenatal care randomized controlled trial in Canada: implications for program planning. BMC Public Health. 2007; 7, 148.
72.Holloway JW, Yang IA, Holgate ST. Genetics of allergic disease. J Allergy Clin Immunol. 2010; 125(Suppl 2), S81S94.
73.Najt P, Fusar-Poly P, Brambilla P. Co-occurring mental and substance abuse disorders: a review on the potential predictors and clinical outcomes. Psychiatry Res. 2010; 186, 159164.
74.Kuczkowski KM. The effects of drug abuse on pregnancy. Curr Opin Obstet Gynecol. 2007; 19, 578585.
75.Vardavas CI, Chatzi L, Patelarou E, et al. Smoking and smoking cessation during early pregnancy and its effect on adverse pregnancy outcomes and fetal growth. Eur J Pediatr. 2010; 169, 741748.
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