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The Effect of Sublethal Concentrations of the Molluscicide Triphenyl Lead Acetate on Biomphalaria glabrata (Say) and on the Development of Schistosoma mansoni in the Snail

Published online by Cambridge University Press:  05 June 2009

G. Webbe
London School of Hygiene and Tropical Medicine


1. B. glabrata exposed to the sublethal concentrations (0·04 ppm, 0·03 ppm and 0·02 ppm) of TPLA died from the effects of the molluscicide over a period of time. Most of the deaths occurred between the 10th and 35th days after treatment, showing that although TPLA is slow acting, its effect is not continuous but restricted to a limited period of time.

2. 0·01 ppm of TPLA was chosen as a sublethal concentration to study the effect of the molluscicide on the development of S. mansoni in B. glabrata.

3. 240 B. glabrata were infected with S. mansoni, and 40 of these were treated with 0·01 ppm of TPLA 4 days before infection. The remaining 200 were divided into 5 groups of 40 each, one group being maintained as a control and the other four treated 2, 10,15 and 20 days postinfection respectively. Other suitable controls for comparison were also maintained.

4. The infection rate in all groups was high, and comparison with the control showed that there was no significant difference in infection rate between the treated groups and the control group at the 5% level. However, the infection rate in the preinfection treated group was lower than in the control group and significant at the 10% level.

Research Article
Copyright © Cambridge University Press 1972

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Frick, L. P. and De Jimenez, W. Q., 1964.—“Molluscicidal properties of three organo-tin compounds revealed by 6-hour and 24-hour exposures against representative stages and sizes of Australorbis glabratus”. Bull. Wld Hlth Org., 31, 429431.Google Scholar
Hopf, H. S. and Muller, R. L., 1962.—“Laboratory breeding and testing of Atislralorbis glabratus for molluscicidal screening.” Bull. Wld Hlth Org., 27, 783789.Google ScholarPubMed
Hopf, H. S., Duncan, J., Beesley, S. S., Weblev, D. J. and Sturrock, R. F., 1967.—“Molluscicidal properties of organo-tin and organo-lead compounds with particular reference to triphenyl lead acetate.” Bull. Wld Hlth Org., 36, 955961.Google Scholar
McClelland, W. F. J., 1965.—“The production of cercariae by Schistosoma mansoni and Schistosoma haemalobium and methods of stimulating cercariae in suspension.” Bull. Wld Hlth Org., 33, 270276.Google Scholar
Massoud, J. and Webbe, G., 1969.—“The effect of sub-lethal doses of the molluscicide (N-tritylmorpholine) on the development of Schistosoma mansoni in Biomphalaria glabrata (Say).” J. Helminth., 43, 99110.CrossRefGoogle Scholar
Sturrock, R. F., 1966.—“The effect of sub-lethal doses of a molluscicide (Bayluscide) on the development of Schistosoma mansoni in Biomphalaria sudanica tanganyicensis.” Bull. Wld Hlth Org., 34, 277283.Google Scholar
Warren, K. S. and Weisberger, A. S., 1966a.—“Suppression of schistosomiasis in snails by Chloramphenicol.” Nature, Lond., 209, 422423.CrossRefGoogle ScholarPubMed
Warren, K. S. and Weisberger, A. S., 1966b.—“The treatment of schistosomiasis mansoni with Chloramphenicol.” Amer. J. trop. Med. Hyg., 15, 342350.CrossRefGoogle ScholarPubMed
Warren, K. S. and Weisberger, A. S., 1967.—“Molluscan schistosomiasis mansoni: Effect of 2 analogues of Chloramphenicol on both parasite and host.” Proc., Soc. exp. Biol. Med., 124, 789791.CrossRefGoogle Scholar
Webbe, G. and Sturrock, R. F., 1964.—“Laboratory tests of some new molluscicides in Tanganyika.” Ann. trop. Med. Parasit., 58, 234239.CrossRefGoogle ScholarPubMed
Who, 1965.—“Molluscicide screening and evaluation.” Bull. Wld Hlth Org., 33, 567581.Google Scholar
Yarinsky, A. and Freele, H., 1970.—“A comparison of molluscicidal and mollusc inhibitory activity of hycanthone and lucanthone and the effect of the drugs on the development of Schistosoma mansoni in the snail intermediate host Australorbis glabratus.” J. trop. Med. Hyg., 73, 2327.Google Scholar