Skip to main content

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
Cancel
×
×
Home
  • Home
Article
  • Cited by 3
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    2000. Handbook of Chemical Risk Assessment.
    Zahner, Horst and Schares, Gereon 1993. Experimental chemotherapy of filariasis: Comparative evaluation of the efficacy of filaricidal compounds in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi and B. pahangi. Acta Tropica, Vol. 52, Issue. 4, p. 221.
    Denham, D. A. Midwinter, I. T. C. and Friedheim, E. A. H. 1990. The anthelmintic activity of a novel organic arsenical, R7/45, upon Brugia pahangi in Meriones unguiculatus. Journal of Helminthology, Vol. 64, Issue. 02, p. 100.
    ×
  • Get access
    Add to cart USD35.00
    Check if you have access via personal or institutional login
    Log in Register Recommend to librarian

The antifilarial activity of a novel group of organic arsenicals upon Brugia pahangi

  • D. A. Denham (a1), Sheree L. Oxenham (a1), I. Midwinter (a1) and E. A. H. Friedheim (a1)
Abstract

Mel W is a second generation anionic organic arsenical which is filaricidal but has sporadic and unacceptable lethal side effects. Eight new cationic derivatives have now been synthesized in an attempt to avoid the side effects and have been examined for their effects upon adult Brugia pahangi in Meriones unguiculatus. They were all shown to be potent filaricides and the two best compounds, Mel Ga and Mel Cy, were at least 95% effective in killing adult B. pahangi at 5x3–13 mg/kg when injected subcutaneously.

Copyright
COPYRIGHT: © Cambridge University Press 1986
References
Hide All
Denham, D. A. (1982) Experience with a screen for macrofilaricidal activity using transplanted adult Brugia pahangi in the peritoneal cavities of Meriones unguiculatus. In: Animal Models in Parasitology, (editor, Owen, Dawn G.), pp. 93–104. Macmillan Press Ltd: London.
Denham, D. A. & Fitzsimons, D. W. (1983) The filaricidal activity of some derivatives of N-[2-(4-thiazolyl) benzimidazole-5-yl]benzamide against Brugia pahangi adults. Methods and Findings in Experimental and Clinical Pharmacology, 5, 45–47.
Denham, D. A. & Mellor, P. (1976) The anthelmintic effects of a new compound “E” (Friedheim) on Onchocerca gutturosa in the cow—a possible tertiary screening system for drug action against O. volvulus in man. Journal of Helminthology, 50, 49–52.
Denham, D. A., Samad, R., Cho, S-Y., Suswillo, R. R. & Skippins, S. C. (1979) The anthelmintic effects of flubendazole on Brugia pahangi. Transactions of the Royal Society of Tropical Medicine and Hygiene, 73, 673–676.
Denham, D. A., Suswillo, R. R., Rogers, R., Mcgreevy, P. B. & Andrews, B. J. (1976) Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product. Journal of Helminthology, 50, 243–250.
Friedheim, E. A. H. (1961) Quelques observations concernant Ie pentyl-thiarsaphenyl-melamine (Mel W) dans Ie traitement des filarioses à O. volvulus et W. bancrofti. Annales de la Société Beige de Médecine Tropicale, 4, 367–373.
Friedheim, E. A. H. (1962a) Mel W in the treatment of filariasis due to W. bancrofti: Results in 35 cases observed for 10–12 months after treatment. Annals of Tropical Medicine and Parasitology, 56, 337–342.
Friedheim, E. A. H. (1962b) Mel W in the treatment of onchocerciasis in leprosy patients: Results in 12 cases observed for 20 months after treatment. Annals of Tropical Medicine and Parasitology, 56, 343–351.
Friedheim, E. A. H. (1974) Therapeutic field trial of a macro- and micro-filaricidal agent in canine filariasis. Bulletin of the World Health Organization, 50, 572–574.
Friedheim, E. A. H. & De Jongh, R. T. (1959) L'effet du pentylthiarsaphenylmelamine (Mel W) sur W. bancrofti. Bulletin de la Société de Pathologie Exotique, 52, 785–791.
Friedheim, E. A. H. & De Jongh, R. T. (1960) Deux observations d'effets the“rapeutiques dans l'onchocercose apres un traitement au Mel W et au TWSb. Bulletin de la Société de Pathologie Exotique, 53, 43–46.
Goodwin, L. G. (1984) Chemotherapy. In: Recent Advances in Research on Filariasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 78 (Suppl.), 1–8.
Soulsby, E. J. L. (1968) Helminths, Arthropods and Protozoa of Domesticated Animals. Bailliere, Tindall and Cassell Ltd.: London.
Suswillo, R. R. & Denham, D. A. (1977) A new system of testing for filaricidal activity using transplanted adult Brugia in the jird. Journal of Parasitology, 63, 591–592.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *

CAPTCHA *

Skip to the audio challenge
×

Keywords:

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 2 *
Loading metrics...

Abstract views

Total abstract views: 44 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 12th June 2018. This data will be updated every 24 hours.

Cancel
Confirm
×