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Cestocidal activity of Acacia auriculiformis

  • N.K. Ghosh (a1), S.P. Sinha Babu (a1), N.C. Sukul (a1) and A. Ito (a2)
Abstract

The cestocidal activity of Acacia auriculiformis was evaluated using rats each harbouring a single adult worm of Hymenolepis diminuta. The ethanol extract (300 mg/kg/day) and the saponins (200 mg/kg/day) obtained from the funicles of A. auriculiformis, were administered orally to two groups each of 10 rats, respectively, on day 20 after oral inoculation with a single cysticercoid of H. diminuta. Adult worms were expelled within 5 days from rats treated with the ethanol extract and within 3 days from those treated with saponins. No appreciable side effects were observed in the treated rats.

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COPYRIGHT: © Cambridge University Press 1996
References
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Chatterjee, A. & Sukul, N.C. (1981) Nematicidal action of three wild plants. Nematologica 26, 500–502.
Chatterjee, R.K., Fatma, N., Murthy, P.K., Sinha, P., Kulshrestha, D.K. & Dhawan, B.N. (1992) Macro-filaricidal activity of the stembark of Streblus asper and its major active constituents. Drug Development Research 26, 1–12.
Ghosh, M., Sinha, Babu S.P., Sukul, N.C. & Mahato, S.B. (1993) Antifilarial effect of two triterpenoid saponins isolated from Acacia auriculiformis. Indian Journal of Experimental Biology 31, 604–606.
Ghosh, M., Sinha, Babu S.P., Sukul, N.C., Sahu, N.P. & Mahato, S.B. (1994) Antifilarial effect of solamargine isolated from Solanum khasianum. International Journal of Pharmacognosy 32 (2), 184–190.
Ito, A. & Onitake, K. (1987) Hymenolepis diminuta and H. nana: Cross immunity against the lumen phase in BALB/c mice. Experimental Parasitology 64, 48–52.
Mahato, S.B., Pal, B.C. & Nandy, A.K. (1992) Structure elucidation of two acylated triterpenoid bis-glycosides from Acacia auriculiformis Cunn. Tetrahedron 48, 6717–6728.
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Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
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