Skip to main content
×
Home
    • Aa
    • Aa

Dexamethasone treatment affects skin mucous cell density in Gyrodactylus derjavini infected Salmo salar

  • S.H. Olafsdottir (a1) and K. Buchmann (a1)
Abstract
Abstract

Atlantic salmon, Salmo salar, is normally rather refractive to infection with the ectoparasitic monogenean Gyrodactylus derjavini but dexamethasone treatment of the host increases the susceptibility. The causative mechanisms were elucidated in this work. Groups of Atlantic salmon were treated by intra-peritoneal dexamethasone injections and subsequently infected with G. derjavini. It was shown that both the infection level and the mucous cell density of caudal and pelvic fins were affected by the treatment. Significantly higher mucous cell densities were found on infected and treated fish whereas non-infected and treated fish showed no significant elevation of cell density. This suggests that mucous cell discharge elicited by infection is inhibited by the drug. The association with elevated parasite counts in these fish can be explained either by decreased anti-parasitic mucus action or by parasite predilection for intact mucous cells.

Copyright
Corresponding author
*Author for correspondence Fax: +45 35282711 E-mail: kub@kvl.dk
References
Hide All
Bakke T.A., Soleng A. & Harris P.D. (1999) The susceptibility of Atlantic salmon (Salmo salar, L.) × brown trout (Salmo trutta, L.) hybrids to Gyrodactylus salaris Malmberg and Gyrodactylus derjavini Mikailov. Parasitology 119, 467481.
Bakke T.A., Soleng A., Lunde H. & Harris P.D. (2000) Resistance mechanisms in Salmo salar stocks infected with Gyrodactylus salaris Abstract. Proceedings EMOP VIII, Poznan, September 2000. Acta Parasitologia 45, 272.
Bakke T.A., Harris P.D. & Cable J. (2002) Host specificity dynamics: observations on gyrodactylid monogeneans. International Journal for Parasitology 32, 281308.
Bayne C.J., Gerwick L., Fujiki K., Nakao M. & Yano T. (2001) Immune relevant (including acute phase) genes identified in the liver of rainbow trout Oncorhynchus mykiss by means of suppression subtractive hybridisation. Developmental and Comparative Immunology 25, 205217.
Buchmann K. (1998) Binding and lethal effect of complement from Oncorhynchus mykiss on Gyrodactylus derjavini (Platyhelminthes, Monogenea). Diseases of Aquatic Organisms 32, 195200.
Buchmann K. (1999) Immune mechanisms in fish skin against monogeneans–a model. Folia Parasitologica 46, 19.
Buchmann K. (2001) Lectins in fish skin: do they play a role in monogenean-fish host interactions? Journal of Helminthology 75, 227232.
Buchmann K. & Bresciani J. (1998) Microenvironment of Gyrodactylus derjavini on rainbow trout Oncorhynchus mykiss : association between mucous cell density in skin and site selection. Parasitology Research 84, 1724.
Buchmann K. & Bresciani J. (1999) Rainbow trout leukocyte activity: influence on the ectoparasitic monogenean Gyrodactylus derjavini. Diseases of Aquatic Organisms 35, 1322.
Buchmann K. & Uldal A. (1997) Gyrodactylus derjavini infections in four salmonids: comparative host susceptibility and site selection of parasites. Diseases of Aquatic Organisms 28, 201209.
Dalgaard M.B., Nielsen C.V. & Buchmann K. (2003) Comparative susceptibility of two races of Salmo salar (Baltic Lule river and Atlantic Conon river strains) to infection with Gyrodactylus salaris. Diseases of Aquatic Organisms 53, 173176.
Harris P.D., Soleng A. & Bakke T.A. (1998) Killing of Gyrodactylus salaris (Platyhelminthes, Monogenea) mediated by host complement. Parasitology 117, 137143.
Harris P.D., Soleng A. & Bakke T.A. (2000) Increased susceptibility of salmonids to the monogenean Gyrodactylus salaris following administration of hydrocortisone acetate. Parasitology 120, 5764.
Lindenstrøm T. & Buchmann K. (1998) Dexamethasone treatment increases susceptibility of rainbow trout, Oncorhynchus mykiss (Walbaum), to infections with Gyrodactylus derjavini Mikailov. Journal of Fish Diseases 21, 2938.
Lindenstrøm T. Buchmann K. & Secombes C.J. (2003) Gyrodactylus derjavini elicits IL-1 beta expression in rainbow trout skin. Fish and Shellfish Immunology 15, 107115.
Moore M.M., Kaattari S.L. & Olson R.E. (1984) Biologically active factors against the monogenetic trematode Gyrodactylus stellatus in the serum and mucus of infected juvenile English soles. Journal of Aquatic Animal Health 6, 93100.
Olafsdottir S.H., Lassen H.P.O. & Buchmann K. (2003) Labile resistance of Atlantic salmon, Salmo salar, L., to infections with Gyrodactylus derjavini Mikailov, 1975: implications for host specificity. Journal of Fish Diseases 25, 14.
Pagniello K.B., Bols N.C. & Lee L.E. (2002) Effect of corticosteroids on viability and proliferation of the rainbow trout monocyte/macrophage cell line, RTS11. Fish and Shellfish Immunology 13, 199214.
Sterud E., Harris P.H. & Bakke T.A. (1998) The influence of Gyrodactylus salaris Malmberg, 1957 (Monogenea) on the epidermis of Atlantic salmon, Salmo salar, L. and brook trout, Salvelinus fontinalis (Mitchill), experimental studies. Journal of Fish Diseases 21, 257263.
Wells P.R. & Cone D.K. (1990) Experimental studies on the effect of Gyrodactylus colemanensis and G. salmonis (Monogenea) on the density of mucous cells in the epidermis of fry of Oncorhynchus mykiss. Journal of Fish Biology 37, 599603.
Zou J., Holland J., Pleguezuelos O., Cunningham C. & Secombes C.J. (2000) Factors influencing the expression of interleukin-1 beta in cultured rainbow trout (Oncorhynchus mykiss) leucocytes. Developmental and Comparative Immunology 24, 575582.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 12 *
Loading metrics...

Abstract views

Total abstract views: 68 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd October 2017. This data will be updated every 24 hours.