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Comparative efficacy of standard antihookworm drugs against various test nematodes

  • Anuradha Misra (a1), P. K. S. Visen (a1) and J. C. Katiyar (a1)

The chemotherapeutic responses of three test nematodes, Nippostrongylus brasilietxsis, Nematospiroidesdubius and Ancylostoma ceylanicum to standard antihookworm drugs were assessed in order to select asuitable host-parasite system for the primary screening of potential antihookworm compounds. N. dubiusbehaved inconsistently and, with some infections, required more drug to achieve 100% clearance. Nippostrongylus brasiliensis was found to be sensitive to thiabendazole, tetramisole and levamisole but the broad spectrum anthclmintic mebendazole was ineffective. A. ceylanicum was very sensitive to mebendazole, sensitive to tetramisole and levamisole and refractory to thiabendazole. In vitro, none of the compounds had any lethal effect against any of the nematodes, except mebendazole against A. ceylanicum.

A. ceylanicum does occur in man and its chemotherapeutic reactions are similar to those of target hookworm infections of economic importance. As such, although not equally sensitive to standard anthelmintics, it is recommended for routine primary screening.

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A. W.J. Broome N. Greenhalgh (1961) A New Anthelmintic With Unusual properties. Nature, 189, 5960.

F. C Copp , O. D. Standen J. Scarnwell , D. A. Rawes & R. B. Burrow (1958) A new scries of anthelmintics. Nature, 181, 183.

D. K. Ray K. K. Bhopale & V. B. Srivastava (1978) Efficacy Of Seven Anthelmintics against A ncylostoma ceylanicum in golden hamsters. Mesocricetus auratus. A nnals of Tropical Medicine and Parasitology, 72, 5558.

G. Sheffield J. E. Meisenhelder & P. E. Thompson . (1959) The Effects of reference anthelmintics against N. dubius and oxyurids in mice relative to screening procedures for new drugs. Journal of Parasitology, 45, 653658.

O. J. Stone J. F. F. Mullins. & C. C. Willis (1965) In Vitro Studies On Ancylostoma caninum with abendazole with observations on larval exshcathment. Journal of Investigative Dermatology, 44, 256258.

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Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
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