Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-17T19:08:46.466Z Has data issue: false hasContentIssue false
  • English
  • Français

Efficacy of pharmacokinetic interactions between piperonyl butoxide and albendazole against gastrointestinal nematodiasis in goats

Published online by Cambridge University Press:  13 November 2015

N.K. Kumbhakar ,
P.K. Sanyal ,
D. Rawte ,
D. Kumar ,
A.E. Kerketta  and
S. Pal
N.K. Kumbhakar
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, Durg-491 001, Chhattisgarh, India
P.K. Sanyal*
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, Durg-491 001, Chhattisgarh, India
D. Rawte
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, Durg-491 001, Chhattisgarh, India
D. Kumar
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, Durg-491 001, Chhattisgarh, India
A.E. Kerketta
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, Durg-491 001, Chhattisgarh, India
S. Pal
Affiliation:
Department of Veterinary Parasitology, College of Veterinary Science and Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, Durg-491 001, Chhattisgarh, India
*
*Fax: 91-788-2252139 E-mail: sanyalprabir54@googlemail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

To test the hypothesis that modulation of hepatic microsomal sulphoxidation and sulphonation by the cytochrome P450 inhibitor piperonyl butoxide could increase bioavailability of albendazole, the present study was undertaken to understand the pharmacokinetics of albendazole in goats at a dose of 7.5 mg kg− 1 body weight with and without co-administration with piperonyl butoxide at 63.0 mg kg− 1 body weight. Plasma albendazole sulphoxide metabolite, the anthelmintically active moiety, reached its maximum concentration of 0.322 ± 0.045 μg ml− 1 and 0.384 ± 0.013 μg ml− 1 at 18 h and 24 h after administration of albendazole alone and co-administration of albendazole with piperonyl butoxide, respectively. Analysis of the data revealed statistically increased albendazole sulphoxide levels at 24 (P <  0.001), 30 (P <  0.001) and 36 h (P <  0.01) after administration of albendazole with piperonyl butoxide, with statistically increased levels of albendazole sulphone at 24, 30 and 48 h after administration. No significance difference (P > 0.05) in values of maximum concentration (normal and calculated) could be observed between groups of goats. However, values of time to reach the concentration maximum (normal and calculated), area under the concentration–time curve (0–∞ and calculated), minimum residence time, distribution half-life, elimination half-life and total area under the first movement of plasma drug concentration–time curve were significantly higher (P <  0.05) in plasma levels of albendazole sulphoxide in goats following single oral co-administration of albendazole with piperonyl butoxide. The faecal egg count reduction and lower 95% confidence limit for the group treated with albendazole alone were 97 and 68%, while for co-administration of albendazole and piperonyl butoxide the values were 99 and 97%, respectively. The ED50 for egg hatch was 0.196, indicating suspected resistance to benzimidazole anthelmintics. The drug combination proved efficacious against an albendazole-resistant nematode parasite population in goats.

Type
Research Papers
Information
Journal of Helminthology , Volume 90 , Issue 5 , September 2016 , pp. 624 - 629
Copyright
Copyright © Cambridge University Press 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benchaoui, H.A. & McKellar, Q.A. (1996) Interaction between fenbendazole and piperonyl butoxide: pharmacokinetic and pharmacodynamic implications. Journal of Pharmacy and Pharmacology 48, 753–759.Google Scholar
Bruni, S.F.S., Fuse, L.A., Moreno, L., Saumell, C.A., Álvarez, L.I., Fiel, C., McKellar, Q.A. & Lanusse, C.E. (2005) Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses. Equine Veterinary Journal 37, 257–262.Google Scholar
Coles, G.C., Bauer, C., Borgsteede, F.H.M., Geerts, S., Klei, T.R., Taylor, M.A. & Waller, P.J. (1992) World Association for the Advancement of Veterinary Parasitology (WAAVP) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Veterinary Parasitology 44, 35–44.Google Scholar
Coles, G.C., Jackson, F., Pomroy, W.E., Prichard, R.K., von Samson-Himmelstjerna, G., Silvestre, A., Taylor, M.A. & Vercruysse, J. (2006) The detection of anthelmintic resistance in nematodes of veterinary importance. Veterinary Parasitology 136, 167–185.Google Scholar
Franklin, M.R. (1977) Inhibition of mixed function oxidations by substrates forming reduced cytochrome P-450 metabolic intermediate complexes. Pharmacology and Therapeutics 2, 227–245.Google Scholar
Gyurik, R.J., Chow, A.W., Zaber, B., Brunner, E.L., Miller, J.A., Villani, A.J., Petka, I.A. & Parish, R.C. (1981) Metabolism of albendazole in cattle, sheep, rats and mice. Drug Metabolism and Disposition 9, 503–508.Google Scholar
Hennessy, D.R. (1994) The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock. Acta Tropica 56, 125–141.Google Scholar
Hennessy, D.R., Lacey, E., Prichard, R.K. & Steel, J.W. (1985) Potentiation of the anthelmintic activity of oxfendazole by parbendazole. Journal of Veterinary Pharmacology and Therapeutics 8, 270–275.CrossRefGoogle ScholarPubMed
Hennessy, D.R., Steel, J.W., Lacey, E., Eagleson, G.K. & Prichard, R.K. (1989) The disposition of albendazole in sheep. Journal of Veterinary Pharmacology and Therapeutics 12, 421–429.Google Scholar
Lanusse, C., Nare, B. & Prichard, R. (1993) Comparative sulphoxidation of albendazole by sheep and cattle liver microsomes and the inhibitory effect of methimazole. Xenobiotica 23, 285–296.CrossRefGoogle ScholarPubMed
Martin, P.J. & Wursthorn, L. (1991) RESO faecal egg count reduction test calculator. Melbourne, Australia, Council of Scientific and Industrial Research Organization, Division of Animal Health.Google Scholar
Murray, M., Hudson, A.M. & Yassa, V. (1992) Hepatic microsomal metabolism of the anthelmintic benzimidazole fenbendazole: enhanced inhibition of cytochrome P450 reactions by oxidised metabolites of the drug. Chemical Research in Toxicology 5, 60–66.Google Scholar
Prichard, R.K., Hennessy, D.R. & Steel, J.W. (1978) Prolonged administration: a new concept for increasing spectrum and effectiveness of anthelmintics. Veterinary Parasitology 4, 309–315.Google Scholar
Sánchez, S., Small, J., Jones, D.G. & McKellar, Q.A. (2002) Plasma achiral and chiral pharmacokinetic behaviour of intravenous oxfendazole co-administered with piperonyl butoxide in sheep. Journal of Veterinary Pharmacology and Therapeutics 25, 7–13.Google Scholar
Sanyal, P.K. (1993) Plasma level of fenbendazole metabolites in buffalo and cattle following longterm intraruminal administration. Veterinary Quarterly 15, 157–159.Google Scholar
Sanyal, P.K. (1994) Pharmacokinetic behaviour of fenbendazole in buffalo and cattle. Journal of Veterinary Pharmacology and Therapeutics 17, 1–4.Google Scholar
Sanyal, P.K. (1995) Kinetic disposition of triclabendazole in buffalo compared to cattle. Journal of Veterinary Pharmacology and Therapeutics 18, 370–374.Google Scholar
Sanyal, P.K. (1997) Disposition kinetics of albendazole in goats compared to sheep. Indian Veterinary Journal 74, 213–216.Google Scholar
Sanyal, P.K. (1998) Effect of single and divided dose administration on the pharmacokinetics of albendazole in sheep and goats. Veterinary Journal 155, 311–316.Google Scholar
Skerman, K.D. & Hillard, J.J. (1966) A handbook for studies of helminth parasites of ruminants. Iran, Near East Animal Health Institute; Rome, Food and Agriculture Organization.Google Scholar
Theodorides, V.J., Gyurik, R.J., Kingsbury, W.D. & Parish, R.C. (1976) Anthelmintic activity of albendazole against liver flukes, tapeworms, lung and gastrointestinal round worms. Experientia 32, 702–703.CrossRefGoogle Scholar