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    Turner, Joanne Howell, Alison McCann, Cathy Caminade, Cyril Bowers, Roger G. Williams, Diana and Baylis, Matthew 2016. A model to assess the efficacy of vaccines for control of liver fluke infection. Scientific Reports, Vol. 6, p. 23345.


Immunization with crude antigens plus aluminium hydroxide protects cattle from Fasciola hepatica infection

  • L. Guasconi (a1), M.C. Serradell (a1), J. Borgonovo (a1), A.P. Garro (a1), H. Varengo (a1), G. Caffe (a1) and D.T. Masih (a1)
  • DOI:
  • Published online: 03 March 2011

The ability of total homogenate (TH) of Fasciola hepatica conjugated with aluminium hydroxide (alum) or Freund's complete adjuvant (FCA) to protect cattle against experimental fasciolosis was evaluated. Compared with the infected group, the immunized animals with alum-TH and FCA-TH presented a significant reduction in fluke burden (85.9% and 96.8%, respectively), a higher percentage of short-sized worms, a marked reduction in the released eggs in faeces (89% and 57%, respectively), as well as an increased production of specific antibodies before infection. The alum-TH immunized group also showed a significant increase in the antigen-specific proliferation of peripheral blood mononuclear cells (PBMC) as early as 4 weeks before infection. Although both immunized groups (alum-TH and FCA-TH) were able to develop an efficient protective immune response to metacercarial challenge, an earlier PBMC response, lower hepatic damage and less effect on weight gain were found in alum-immunized animals. Therefore, alum is a good candidate for future immunization against bovine fasciolosis.

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N. Reszka , J.B.W.J. Cornelissen , M.M. Harmsen , K. Biénkowska-Szewczyk , J. de Bree , W.J. Boersma & F.A.M. Rijsewijk (2005) Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against fasciolosis. Vaccine 23, 29872993.

F.J. van Milligen , J.B.W.J. Cornelissen & B.A. Bokhout (2000) Fasciola hepatica: An antigen fraction derived from newly excysted juveniles, containing an immunoreactive 32-kDa protein, induces strong protective immunity in rats. Exerimental Parasitology 94, 163171.

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Journal of Helminthology
  • ISSN: 0022-149X
  • EISSN: 1475-2697
  • URL: /core/journals/journal-of-helminthology
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