Skip to main content Accessibility help
×
Home
Hostname: page-component-55b6f6c457-xklcj Total loading time: 0.292 Render date: 2021-09-25T19:53:38.585Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Aggressive verrucous carcinoma of the paranasal sinuses invading the orbit: case report and literature review

Published online by Cambridge University Press:  11 August 2009

J Yiotakis
Affiliation:
Otorhinolaryngology Department, Athens University, Ippokration General Hospital, Greece
T Vamvakidis*
Affiliation:
Otorhinolaryngology Department, Athens University, Ippokration General Hospital, Greece
E Iakovou
Affiliation:
Otorhinolaryngology Department, Athens University, Ippokration General Hospital, Greece
L Manolopoulos
Affiliation:
Otorhinolaryngology Department, Athens University, Ippokration General Hospital, Greece
*
Address for correspondence: Dr Theodore Vamvakidis, 114 Vas Sofias Av, Athens 11527, Greece. Fax: +30 210 6144290 E-mail: theodorevamb@hotmail.com
Get access

Abstract

Introduction:

Verrucous carcinoma is a variant of well differentiated squamous cell carcinoma characterised by an exophytic, warty growth which is slowly but locally invasive and which can cause extensive local destruction if left untreated.

Case report:

We report the first known case of veruccous carcinoma of the paranasal sinuses with rapid orbital invasion. A 58-year-old man presented with right-sided nasal obstruction, a huge right intranasal lesion, intractable dacryocystitis and cutaneous involvement of the nasolacrimal sac region. The tumour was partially removed using an endoscopic transnasal approach. Post-operatively, and while waiting for the histological result, the patient developed signs of rapid invasion of the orbit, with uniocular visual acuity deficit. He underwent combined radiochemotherapy, with a moderate response.

Conclusion:

Knowledge of the potentially aggressive nature of verrucous carcinoma may be helpful in early management of intraorbital invasion and salvaging of the eye.

Type
Online Only Clinical Records
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Michaels, L. Ear, Nose and Throat Histopathology. London: Springer-Verlag, 1987;171–3CrossRefGoogle Scholar
2Batsakis, JG, Hybels, R, Crissman, JD, Rice, DH. The pathology of head and neck tumors: verrucous carcinoma. Head Neck 1982;5:2938CrossRefGoogle ScholarPubMed
3Ackerman, LV. Verrucous carcinoma of the oral cavity. Surgery 1948;23:670–8Google ScholarPubMed
4Spiro, RH. Verrucous carcinoma, then and now. Am J Surg 1998;176:393–7CrossRefGoogle Scholar
5Shear, M, Pindborg, JJ. Verrucous hyperplasia of the oral mucosa. Cancer 1980;46:1855–623.0.CO;2-#>CrossRefGoogle ScholarPubMed
6Sternberg, SS. Diagnostic Surgical Pathology. Philadelphia PA: Lipincott-Raven, 1996;906–8Google Scholar
7Mody, RN, Shastri, P. Oral verrucous carcinoma. A case report with review of literature. Journal of Indian Academy of Oral Medicine and Radiology 1998;9:30–3Google Scholar
8Proffitt, SD, Spooner, TR, Kosek, JC. Origin of undifferentiated neoplasm from verrucous epidermal carcinoma of oral cavity following irradiation. Cancer 1970;26:379–933.0.CO;2-4>CrossRefGoogle ScholarPubMed
9Kasperbauer, JL, O'Halloran, GI, Espy, MJ, Smith, TF, Lewis, JE. Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx. Laryngoscope 1993;103:416–20CrossRefGoogle ScholarPubMed
10Miller, CS, White, DK. Human papillomavirus expression in oral mucosa, premalignant conditions and squamous cell carcinoma: a retrospective review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1966;82:5768CrossRefGoogle Scholar
11Venuti, A, Manni, V, Morello, R, De Marco, F, Marzetti, F, Marcante, ML. Physical state and expression of human papillomavirus in laryngeal carcinoma and surrounding normal mucosa. J Med Virol 2000;60:3964023.0.CO;2-V>CrossRefGoogle ScholarPubMed
12Eisenberg, E, Rosenberg, B, Krutchkoff, DJ. Verrucous carcinoma: a possible viral pathogenesis. Oral Surg Oral Med Oral Pathol 1985;59:52–7CrossRefGoogle ScholarPubMed
13Hanna, GS, Ali, MH. Verrucous carcinoma of the nasal septum. J Laryngol Otol 1987;101:184–7CrossRefGoogle ScholarPubMed
14Taybos, GM, Feltman, R, Terezhalmy, GT. Verrucous carcinoma invading the orbit: report of a case. J Oral Med 1983;38:31–4Google ScholarPubMed
15Schwartz, RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 1995;32:116CrossRefGoogle ScholarPubMed
16Albert, K, Jakob, A, Rompel, R. Multimodal ablative therapy of florid oral papillomatosis [in German]. J Dtsch Dermatol Ges 2008;6:505–6CrossRefGoogle ScholarPubMed
17Akyol, A, Anadolu, R, Anadolu, Y, Ekmekci, P, Gürgey, E, Akay, N. Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha-2b. Int J Dermatol 2003;42:733–5CrossRefGoogle ScholarPubMed
18Ferlito, A, Devaney, KO, Rinaldo, A, Putzi, MJ. Papillary squamous cell carcinoma versus verrucous squamous cell carcinoma of the head and neck. Ann Otol Rhinol Laryngol 1999;108:318–22CrossRefGoogle ScholarPubMed
19Winnen, P. Intrafocal bleomycin injection in florid oral papillomatosis (papillomatosis mucosae carcinoides) [in German]. Z Hautkr 1983;58:733–41Google Scholar
20Scheuermann, K, Delank, KW. Ackerman's tumor of the larynx and occupational exposure to asbestos [in German]. Laryngorhinootologie 2007;86:588–91CrossRefGoogle ScholarPubMed
21Walvekar, RR, Chaukar, DA, Deshpande, MS, Pai, PS, Chaturvedi, P, Kakade, A et al. Verrucous carcinoma of the oral cavity: a clinical and pathological study of 101 cases. Oral Oncol 2009;45:4751CrossRefGoogle ScholarPubMed
22Ferlito, A, Recher, G. Ackerman's tumor (verrucous carcinoma) of the larynx: a clinicopathologic study of 77 cases. Cancer 1980;46:1617–303.0.CO;2-T>CrossRefGoogle ScholarPubMed
23Paleri, V, Orvidas, LJ, Wight, RG, Bradley, PJ. Verrucous carcinoma of the paranasal sinuses: case report and clinical update. Head Neck 2004;26:184–9CrossRefGoogle ScholarPubMed
24Hagiwara, H, Kanazawa, T, Ishikawa, K, Fujii, T, Kitamura, K, Noguchi, Y et al. Invasive verrucous carcinoma: a temporal bone histopathology report. Auris Nasus Larynx 2000;27:179–83CrossRefGoogle ScholarPubMed
25Proops, DW, Hawke, WM, Harwood, AR, van Norstrand, AWP, Lunan, M. Verrucous carcinoma of the ear. Ann Otol Rhinol Laryngol 1984;93:385–88CrossRefGoogle ScholarPubMed
26Woodson, GE, Jurco, S, Alford, BR, McGavran, MH. Verrucous carcinoma of the middle ear. Arch Otolaryngol 1981;107:63–5CrossRefGoogle ScholarPubMed
27McCoy, JM, Waldron, CA. Verrucous carcinoma of the oral cavity. A review of forty-nine cases. Oral Surg Oral Med Oral Pathol 1981;52:623–9CrossRefGoogle ScholarPubMed
28Pothula, VB, Jones, HS. Verrucous squamous carcinoma of the nasal septum. J Laryngol Otol 1998;112:172–3CrossRefGoogle ScholarPubMed
29Vico, P, Nagypal, P, Rahier, I, Deraemaecker, R. Verrucous carcinoma of the nasal septum and columella. Acta Chir Belg 1997;97:50–1Google ScholarPubMed
30Jahn, AF, Walter, JB, Farkashidy, J. Verrucous carcinoma of the nasopharynx – a clinicopathologic case report. J Otolaryngol 1980;9:84–9Google ScholarPubMed
31Rajendran, R, Sugathan, CK, Augustine, J. Ackerman's tumor (verrucous carcinoma) of the oral cavity: a histopathologic study of 426 cases. Singapore Dental J 1989;14:4853Google ScholarPubMed
32Kolbusz, RV, Goldberg, LH. Verrucous carcinoma of the oral cavity. Int J Dermatol 1994;33:618–22Google Scholar
33Mosesson, RE, Som, PM. The radiographic evaluation of sinonasal tumors. Otolaryngol Clin North Am 1995;28:1097–115Google ScholarPubMed
34Karthikeya, P, Mahima, VG, Bhavna, G. Sinonasal verrucous carcinoma with oral invasion. Indian J Dent Res 2006;17:82–6CrossRefGoogle ScholarPubMed
35Nunez, F, Suarez, C, Alvarez, I, Losa, JL, Barthe, P, Fresno, M. Sino-nasal adenocarcinoma: epidemiological and clinico-pathological study of 34 cases. J Otolaryngol 1993;22:8690Google ScholarPubMed
36Szentirmay, Z, Pólus, K, Tamás, L, Szentkuti, G, Kurcsics, J, Csernák, E et al. Human papillomavirus in head and neck cancer: molecular biology and clinicopathological correlations. Cancer Metastasis Rev 2005;24:1934CrossRefGoogle ScholarPubMed
37Multhaupt, HA, Fessler, JN, Warhol, MJ. Detection of human papillomavirus in laryngeal lesions by in situ hybridization. Hum Pathol 1994;25:1302–5CrossRefGoogle ScholarPubMed
38Wu, M, Putti, TC, Bhuiya, TA. Comparative study in the expression of p53, EGFR, TGF-alpha, and cyclin D1 in verrucous carcinoma, verrucous hyperplasia, and squamous cell carcinoma of head and neck region. Appl Immunohistochem Mol Morphol 2002;10:351–6CrossRefGoogle ScholarPubMed
39Shiomori, T, Udaka, T, Nagatani, G, Fujimura, T, Ohbuchi, T, Sasaguri, T et al. Association of verrucous carcinoma and inverted papilloma in the sinonasal tract. Auris Nasus Larynx 2007;34:281–5CrossRefGoogle ScholarPubMed
40Schwartz, RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 1995;32:116CrossRefGoogle ScholarPubMed
41Go, JH, Oh, YL, Ko, YH. Hybrid verrucous squamous cell carcinoma of sinonasal tract: a case report. J Korean Med Sci 1998;13:662–4CrossRefGoogle ScholarPubMed
42Yazici, B, Setzen, G, Meyer, DR. Giant cell angiofibroma of the nasolacrimal duct. Ophthal Plast Reconstr Surg 2001;17:202–6CrossRefGoogle ScholarPubMed
43Khan, MA, Dhillon, B. Epiphora due to Kaposi's sarcoma of the nasolacrimal duct. Br J Ophthalmol 1999;83:501–2CrossRefGoogle ScholarPubMed
44Lewis, AM, Clarke, PM, Oliver, JM. Primary nasolacrimal duct malignant mucosal melanoma. Br J Ophthalmol 2006;90:114–15CrossRefGoogle ScholarPubMed
45Baredes, S, Ludwin, DB, Troublefield, YL, Langer, PD, Mirani, N. Adenocarcinoma ex-pleomorphic adenoma of the lacrimal sac and nasolacrimal duct: a case report. Laryngoscope 2003;113:940–2CrossRefGoogle ScholarPubMed
46Spira, R, Mondshine, R. Demonstration of nasolacrimal duct carcinoma by computed tomography. Ophthal Plast Reconstr Surg 1986;2:159–61CrossRefGoogle ScholarPubMed
47Sakaida, H, Kobayashi, M, Yuta, A, Imanishi, Y, Majima, Y. Squamous cell carcinoma of the nasolacrimal duct. Eur Arch Otorhinolaryngol 2009;266:455–8CrossRefGoogle ScholarPubMed
48Ahmad, SM, Esmaeli, B. Metastatic tumors of the orbit and ocular adnexa. Curr Opin Ophthalmol 2007;18:405–13CrossRefGoogle ScholarPubMed
49Capone, A Jr, Slamovits, TL. Discrete metastasis of solid tumors to extraocular muscles. Arch Ophthalmol 1990;108:237–43CrossRefGoogle ScholarPubMed
50Orvidas, LJ, Kerry, DK, Lewis, JE, Suman, VJ. Verrucous carcinoma of the larynx: a review of 53 patients. Head Neck 1998;20:1972033.0.CO;2-W>CrossRefGoogle ScholarPubMed
51Slootweg, PJ, Muller, H. Verrucous hyperplasia or verrucous carcinoma. An analysis of 27 patients. J Maxillofac Surg 1983;11:1319CrossRefGoogle ScholarPubMed
52Shear, M, Pindborg, JJ. Verrucous hyperplasia of the oral mucosa. Cancer 1980;46:1855–623.0.CO;2-#>CrossRefGoogle ScholarPubMed
53Schrader, M, Laberke, HG. Differential diagnosis of verrucous carcinoma in the oral cavity and larynx. J Laryngol Otol 1988;102:700–3CrossRefGoogle ScholarPubMed
54Cooper, JR, Hellquist, H, Michaels, L. Image analysis in the discrimination of verrucous carcinoma and squamous papilloma. J Pathol 1992;166:383–7CrossRefGoogle ScholarPubMed
55Koch, BB, Trask, DK, Hoffman, HT, Karnell, LH, Robinson, RA, Zhen, W et al. National survey of head and neck verrucous carcinoma: patterns of presentation, care, and outcome. Cancer 2001;92:110–203.0.CO;2-K>CrossRefGoogle ScholarPubMed
56Nair, MK, Sankaranarayanan, R, Padmanabhan, TK, Madhu, CS. Oral verrucous carcinoma. Treatment with radiotherapy. Cancer 1988;61:458–613.0.CO;2-T>CrossRefGoogle ScholarPubMed
57Yoshimura, Y, Mishima, K, Obara, S, Nariai, Y, Yoshimura, H, Mikami, T. Treatment modalities for oral verrucous carcinomas and their outcomes: contribution of radiotherapy and chemotherapy. Int J Clin Oncol 2001;6:192200CrossRefGoogle ScholarPubMed
58Huang, SH, Lockwood, G, Irish, J, Ringash, J, Cummings, B, Waldron, J et al. Truths and myths about radiotherapy for verrucous carcinoma of larynx. Int J Radiat Oncol Biol Phys 2009;15:1110–5CrossRefGoogle Scholar
59Strong, MS. Diagnosis and treatment of verrucous squamous cell carcinoma of the larynx: a critical review. Trans Am Laryngol Assoc 1985;106:163–4Google Scholar
60Strojan, P, Soba, E, Budihna, M, Auersperg, M. Radiochemotherapy with vinblastine, methotrexate, and bleomycin in the treatment of verrucous carcinoma of the head and neck. J Surg Oncol 2005;92:278–83CrossRefGoogle ScholarPubMed
7
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Aggressive verrucous carcinoma of the paranasal sinuses invading the orbit: case report and literature review
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Aggressive verrucous carcinoma of the paranasal sinuses invading the orbit: case report and literature review
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Aggressive verrucous carcinoma of the paranasal sinuses invading the orbit: case report and literature review
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *