Skip to main content Accessibility help
×
Home
Hostname: page-component-55597f9d44-ssw5r Total loading time: 0.233 Render date: 2022-08-08T06:53:00.593Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true

Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer

Published online by Cambridge University Press:  19 May 2008

U M Rashad*
Affiliation:
Department of Otolaryngology, Oncology, Faculty of Medicine, Assiut University, Egypt
S M Al-Gezawy
Affiliation:
Department of Otolaryngology, Oncology, Faculty of Medicine, Assiut University, Egypt
E El-Gezawy
Affiliation:
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Egypt
A N Azzaz
Affiliation:
Agronomy Department, Agriculture Faculty, Assiut Branch, Al-Azhar University, Egypt
*
Address for correspondence: Dr Usama M Rashad, Department of Surgery, ENT Sector, Al Ahsaa-College of Medicine, King Faisal University, 31982, PO 400, Saudi Arabia. E-mail: urashad2008@yahoo.com

Abstract

Aim:

To evaluate the efficacy of pure natural honey as prophylaxis against radiochemotherapy-induced mucositis, through clinical scoring of oral and oropharyngeal mucositis, and culturing of pathogenic oral and oropharyngeal microbes.

Patients and methods:

The study was done in Assiut University Hospital, Egypt, between January 2005 and July 2006. Forty patients diagnosed with head and neck cancer were entered into the trial. Enrolled patients were randomised to either the treatment group, receiving concomitant chemotherapy and radiotherapy (with a significant area of directly visible oral and/or oropharyngeal mucosa included in the radiation fields) plus prior topical application of pure natural honey, or the control group, receiving concomitant chemotherapy and radiotherapy without honey. Patients were evaluated clinically every week to assess development of radiation mucositis. Aerobic cultures and candida colonisation assessment were undertaken, via oral and oropharyngeal swabs, prior to and at the completion of irradiation, and when infection was evident.

Results:

In the treatment group, no patients developed grade four mucositis and only three patients (15 per cent) developed grade three mucositis. In the control group, 13 patients (65 per cent) developed grade three or four mucositis (p < 0.05). Candida colonisation was found in 15 per cent of the treatment group and 60 per cent of the control group, either during or after radiotherapy (p = 0.003). Positive cultures for aerobic pathogenic bacteria were observed in 15 per cent of the treatment group and 65 per cent of the control group, during or after radiotherapy (p = 0.007).

Conclusion:

This study shows that prophylactic use of pure natural honey was effective in reducing mucositis resulting from radiochemotherapy in patients with head and neck cancer.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Stokman, MA, Spijkervet, FK, Burlage, FR. Oral mucositis and selective elimination of oral flora in head and neck cancer patients receiving radiotherapy: a double-blind randomised clinical trial. Br J Cancer 2003;88:1012–16CrossRefGoogle ScholarPubMed
2Al-Tikriti, U, Martin, MV, Bramley, PA. A pilot study of the clinical effects of irradiation on the oral tissues. Br J Oral Maxillofac Surg 1984;22:7786CrossRefGoogle ScholarPubMed
3Bernhoft, CH, Skaug, N. Oral findings in irradiated edentulous patients. Int J Oral Surg 1985;14:416–27CrossRefGoogle ScholarPubMed
4Sonis, ST. A biological approach to mucositis. J Support Oncol 2004;2:21–2Google ScholarPubMed
5Demarosi, F, Bez, C, Carrassi, A. Prevention and treatment of chemo- and radiotherapy-induced oral mucositis. Minerva Stomatol 2002;51:173–86Google ScholarPubMed
6DeVries, A, Sprinzl, G, Reich, K, Gunczler, P, Thumfart, W, Lukas, P. GM-CSF-mouth wash for treatment of chemotherapy patients with advanced head and neck cancer: a clinical trial. Ann Oncol 2001;11(suppl 4):409PDGoogle Scholar
7Hanson, WR, Marks, JE, Reddy, SP. Protection from radiation induced oral mucositis by a mouth rinse containing prostaglandin E analogue, misoprostol: a placebo controlled double blind clinical trial. Adv Exp Med Biol 1997;400B:811–18Google Scholar
8Leborgne, JH, Leborgne, F, Zubizarreta, E, Ortega, B, Mezzera, J. Corticosteroids and radiation mucositis in head and neck cancer. A double-blind placebo-controlled randomised trial. Radiother Oncol 1997;47:145–8CrossRefGoogle Scholar
9Tannehill, SP, Mehta, MP. Amifostine and radiation therapy: past, present and future. Semin Oncol 1996;23(suppl 8):6977Google Scholar
10Zumla, A, Lulat, A. Honey – a remedy rediscovered. J R Soc Med 1989;82:384–5CrossRefGoogle Scholar
11Biswal, BM, Zakaria, A, Ahmad, NM. Topical application of honey in the management of radiation mucositis: a preliminary study. Support Care Cancer 2003;11:242–8Google ScholarPubMed
12Molan, PC. The potential of honey to promote oral wellness. Gen Dent 2001;49:584–9Google ScholarPubMed
13Bergman, A, Yanai, J, Weiss, J, Bell, D, David, MP. Acceleration of wound healing by topical application of honey. Am J Surg 1983;145:374–6CrossRefGoogle ScholarPubMed
14Cooper, RA, Molan, PC, Harding, KG. Antibacterial activity of honey against strains of Staphylococcus aureus from infected wounds. J Roy Soc Med 1999;92:283–5CrossRefGoogle ScholarPubMed
15Sela, MO, Shapira, L, Grizim, I. Effects of honey consumption on enamel microhardness in normal versus xerostomic patients. J Oral Rehabil 1998;25:630–4CrossRefGoogle ScholarPubMed
16Karnofsky, D, Abelman, W, Craver, L, Burchenal, J. The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1948;1:634–563.0.CO;2-L>CrossRefGoogle Scholar
17El-Sayed, S, Nabid, A, Shelley, W. Prophylaxis of radiation-associated mucositis in conventionally treated patients with head and neck cancer: a double-blind, phase III, randomized, controlled trial evaluating the clinical efficacy of an antimicrobial lozenge using a validated mucositis scoring system. J Clin Oncol 2002;20:3956–63CrossRefGoogle ScholarPubMed
18World Health Organization. WHO Handbook for Reporting the Results of Cancer Treatment. Geneva: WHO Offset Publications, 1979Google Scholar
19Rahn, R, Adamietz, IA, Boettcher, HD. Povidone-iodine to prevent mucositis in patients during antineoplastic radiochemotherapy. Dermatology 1997;195(suppl 2):5761CrossRefGoogle ScholarPubMed
20Matthews, RH, Ercal, N. Prevention of mucositis in irradiated head and neck cancer patients. J Exp Ther Oncol 1996;1:135–8Google ScholarPubMed
21Koc, M, Aktas, E. Prophylactic treatment of mycotic mucositis in radiotherapy of patients with head and neck cancers. Japanese Journal of Clinical Oncology 2003;33:5760CrossRefGoogle ScholarPubMed
22Spijkervet, FK, Van Saene, HK, Van Saene, JJ, Panders, AK, Vermey, A, Mehta, DM et al. Effect of selective elimination of the oral flora on mucositis in irradiated head and neck cancer patients. J Surg Oncol 1991;46:167–73CrossRefGoogle ScholarPubMed
23Mucke, R, Kaben, U, Libera, T, Knauerhase, H, Ziegler, PG, Hamann, D et al. Use of fluconazole as antimycotic prophylaxis in radiotherapy of patients with head and neck tumors. Mycoses 1997;40(suppl 1):53–5Google ScholarPubMed
81
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *