Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
Hostname: page-component-ffbbcc459-5mjdh Total loading time: 0.328 Render date: 2022-03-13T06:13:26.481Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true }
  • English
The Journal of Laryngology & Otology The Journal of Laryngology & Otology

Article contents

A rare case of subglottic embryonal rhabdomyosarcoma: managed with the aim of organ preservation

Published online by Cambridge University Press:  22 December 2014

A Jain ,
S N Singh ,
P Singhal  and
M P Sharma
A Jain*
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
S N Singh
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
P Singhal
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
M P Sharma
Affiliation:
Department of Otolaryngology (ENT), Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
*
Address for correspondence: Dr Avani Jain, Flat no C-8, Tower 1, New Moti Bagh, New Delhi 110023, India E-mail: avanijain87@hotmail.com
Get access Rights & Permissions[Opens in a new window]

Abstract

Background:

Rhabdomyosarcoma is a malignant mesenchymal neoplasm rarely diagnosed in the larynx. Traditionally, it has been treated by radical surgery (i.e. total laryngectomy), followed by radiation and/or chemotherapy. Recent advances suggest that it may be treated with combination therapy comprising high-dose radiation and pulse chemotherapy, with a high success rate.

Case report:

We report the first documented case of subglottic embryonal rhabdomyosarcoma in an adolescent female treated with chemoradiation alone, and review the literature reflecting a move towards organ preservation.

Conclusion:

While surgery has been successfully used to treat this neoplasm, combination therapy, as described in our study, also seems effective and has the added advantage of preserving laryngeal function.

Keywords

RhabdomyosarcomaEmbryonalLarynxChemotherapyRadiotherapy
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 1 , January 2015 , pp. 106 - 109
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Harris, HH. Rhabdomyosarcoma of the larynx: Report of a case. Arch Otolaryngol 1961;74:205–9CrossRefGoogle ScholarPubMed
2Ruske, DR, Glassford, N, Costello, S, Stewart, IA. Laryngeal rhabdomyosarcoma in adults. J Laryngol Otol 1998;112:670–2CrossRefGoogle ScholarPubMed
3Masson, JK, Soule, EH. Embryonal rhabdomyosarcoma of the head and neck. Report on eighty cases. Am J Surg 1965;110:585–91CrossRefGoogle Scholar
4DeGroot, TR, Frazier, JP, Wood, BP. Combination therapy for rhabdomyosarcoma of the larynx. Am J Otolaryngol 1980;1:456–60CrossRefGoogle Scholar
5Hicks, J, Flaitz, C. Rhabdomyosarcoma of the head and neck in children. Oral Oncol 2002;38:450–9CrossRefGoogle ScholarPubMed
6Sivanandan, R, Kong, CS, Kaplan, MJ. Laryngeal embryonal rhabdomyosarcoma. Arch Otolaryngol Head Neck Surg 2004;130:1217–22CrossRefGoogle ScholarPubMed
7Fernandes, P, Tandon, DA, Tickoo, SK, Rath, GK. Embryonal rhabdomyosarcoma of the larynx in a child: Report of a case and review of literature. Indian J Cancer 1988;25:89–93Google Scholar
8Hachihanefioglu, U, Ozturk, AS. Sarcomas of the larynx: report of ten cases. Ann Otol Rhinol Laryngol 1983;92:81–4CrossRefGoogle Scholar
9Kedar, A, Kuten, A, Joachims, HZ, Ben-Arieh, Y, Yudelev, M. Rhabdomyosarcoma of the larynx treated by laser surgery combined with radiotherapy and chemotherapy. Med Pediatr Oncol 1983;11:279–80CrossRefGoogle ScholarPubMed
10Diehn, KW, Hyams, VJ, Harris, AE. Rhabdomyosarcoma of the larynx: a case report and review of the literature. Laryngoscope 1984;94:201–5CrossRefGoogle ScholarPubMed
11Dodd-o, JM, Wieneke, KF, Rosman, PM. Laryngeal rhabdomyosarcoma: case report and literature review. Cancer 1987;59:1012–183.0.CO;2-A>CrossRefGoogle ScholarPubMed
12Gross, M, Gutjahr, P. Therapy of rhabdomyosarcoma of the larynx. Int J Pediatr Otorhinolaryngol 1988;15:211–15CrossRefGoogle ScholarPubMed
13Healy, GB, Upton, J, Black, PMCL, Ferraro, N. The role of surgery in rhabdomyosarcoma of the head and neck in children. Arch Otolaryngol Head Neck Surg 1991;117:1185–8CrossRefGoogle ScholarPubMed
14Kato, MADP, Flamant, F, Terrier-Lacombe, MJ, Habrand, JL, Schwaab, G, Luboinski, B et al. Rhabdomyosarcoma of the larynx in children: a series of five patients treated in the Institut Gustave Roussy. Med Pediatr Oncol 1991;19:110–14CrossRefGoogle ScholarPubMed
15Mortele, K, Limmerling, M, Vanzieleghem, B, Moerman, M, Cuvelier, C, Vermeersch, H et al. Laryngeal embryonal rhabdomyosarcoma in a child: MRI appearance. Eur Radiol 1998;8:1251–3Google Scholar
5
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

A rare case of subglottic embryonal rhabdomyosarcoma: managed with the aim of organ preservation
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

A rare case of subglottic embryonal rhabdomyosarcoma: managed with the aim of organ preservation
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

A rare case of subglottic embryonal rhabdomyosarcoma: managed with the aim of organ preservation
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *