Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 3
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Rasmussen, Niels 2013. L24. Local treatments of subglottic and tracheal stenoses in granulomatosis with polyangiitis (Wegener's). La Presse Médicale, Vol. 42, Issue. 4, p. 571.

    Gouveris, Haralampos Karaiskaki, Niki Koutsimpelas, Dimitrios Chongolwatana, Cheerasook and Mann, Wolf 2013. Treatment for adult idiopathic and Wegener-associated subglottic stenosis. European Archives of Oto-Rhino-Laryngology, Vol. 270, Issue. 3, p. 989.

    Emilsson, Össur Ingi Gíslason, Þórarinn Olin, Anna-Carin Janson, Christer and Ólafsson, Ísleifur 2013. Biomarkers for Gastroesophageal Reflux in Respiratory Diseases. Gastroenterology Research and Practice, Vol. 2013, p. 1.


Aspiration and development of subglottic stenosis in patients with Wegener’s granulomatosis

  • A C Church (a1), K Goldsmith (a2) and P Sivasothy (a2)
  • DOI:
  • Published online: 25 November 2009

In patients with Wegener’s granulomatosis, subglottic stenosis can develop due to active disease; however, some patients develop subglottic stenosis with no clear evidence of airway inflammation. In some cases of idiopathic subglottic stenosis, an association with gastroesophageal reflux disease has been found. Our study assessed the potential role of gastroesophageal reflux as an aetiological factor in the development of subglottic stenosis in patients with Wegener’s granulomatosis.


We assessed evidence of active reflux disease, using 24-hour pH monitoring and assessment of bile salts in bronchoalveolar lavage fluid.


Ten Wegener’s granulomatosis patients with subglottic stenosis underwent 24-hour pH monitoring and bronchoscopy and lavage of the right middle lobe. A similar number of control patients were included.


There was no statistically significant difference in the occurrence of bronchoalveolar bile salts in patients with subglottic stenosis (n = 2) versus control patients (zero) (p = 0.457). There was good correlation between the detection of reflux by 24-hour pH monitoring and the detection of bronchoalveolar bile salts (κ = 0.769).


In this small study of patients with Wegener’s granulomatosis, there was no evidence of an association between the development of subglottic stenosis and gastroesophageal reflux.

Corresponding author
Address for correspondence: Dr A C Church, Golden Jubilee Hospital, Beardmore Street, Clydebank, Glasgow G81 4HX, Scotland, UK. Fax: +44 (0)141 2329423 E-mail:
Hide All

Presented at the American Thoracic Society meeting, 15 May 2007, San Francisco, USA.

Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2TE Daum , U Specks , TV Colby , ES Edell , MW Brutinel , UB Prakash Tracheobronchial involvement in Wegener's granulomatosis. Am J Respir Crit Care Med 1995;151:522–6

3JF Cordier , D Valeyre , L Guillevin , R Loire , JM Brechot . Pulmonary Wegener's granulomatosis. A clinical and imaging study of 77 cases. Chest 1990;97:906–12

4NC Maronian , H Azadeh , P Waugh , A Hillel . Association of laryngopharyngeal reflux disease and subglottic stenosis. Ann Otol Rhinol Laryngol 2001;110:606–12

5K Blondeau , V Mertens , BA Vanaudenaerde , GM Verleden , DE Van Raemdonck , D Sifrim Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection. Eur Respir J 2008;31:707–13

6MP Sweet , MG Patti , C Hoopes , SR Hays , JA Golden . Gastro-oesophageal reflux and aspiration in patients with advanced lung disease. Thorax 2009;64:167–73

7F D'Ovidio , M Mura , M Tsang , TK Waddell , MA Hutcheon , LG Singer Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation. J Thorac Cardiovasc Surg 2005;129:1144–52

8R Solans-Laque , J Bosch-Gil , M Canela , J Lorente , E Pallisa , M Vilardell-Tarres . Clinical features and therapeutic management of subglottic stenosis in patients with Wegener's granulomatosis. Lupus 2008;17:832–6

9MB Gluth , PA Shinners , JL Kasperbauer . Subglottic stenosis associated with Wegener's granulomatosis. Laryngoscope 2003;113:1304–7

10WK Kauer , JH Peters , TR DeMeester , H Feussner , AP Ireland , HJ Stein Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease. Surgery 1997;122:874–81

11F D'Ovidio , M Mura , R Ridsdale , H Takahashi , TK Waddell , M Hutcheon The effect of reflux and bile acid aspiration on the lung allograft and its surfactant and innate immunity molecules SP-A and SP-D. Am J Transplant 2006;6:1930–8

13SA Nouraei , R Obholzer , PW Ind , AD Salama , CD Pusey , F Porter Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegener's granulomatosis. Thorax 2008;63:4952

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *