Hostname: page-component-8448b6f56d-dnltx Total loading time: 0 Render date: 2024-04-24T13:57:41.027Z Has data issue: false hasContentIssue false
  • English
  • Français

Association of synchronous medullary and papillary thyroid carcinomas with primary hyperparathyroidism: first case report and literature review

Published online by Cambridge University Press:  30 May 2014

L Cheung ,
D Howlett ,
H El Teraifi  and
P Kirkland
L Cheung*
Affiliation:
Department of ENT, Conquest Hospital, East Sussex Healthcare NHS Trust, St. Leonards-on-Sea, UK
D Howlett
Affiliation:
Department of Radiology, Eastbourne District General Hospital, UK
H El Teraifi
Affiliation:
Department of Pathology, Eastbourne District General Hospital, UK
P Kirkland
Affiliation:
Department of ENT, Conquest Hospital, East Sussex Healthcare NHS Trust, St. Leonards-on-Sea, UK
*
Address for correspondence: Miss L Cheung, Conquest Hospital, East Sussex Healthcare NHS Trust, The Ridge, St. Leonards-on-Sea, TN37 7RDUK E-mail: linnea.cheung@nhs.net
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We report a case of a patient with symptomatic primary hyperparathyroidism who was found, through a thorough radiological investigation, to also have papillary and medullary thyroid carcinomas.

Case report:

A 59-year-old female was diagnosed with primary hyperparathyroidism. A further radiological investigation found suspicious areas within both thyroid lobes that were later diagnosed as foci of papillary and medullary thyroid carcinomas. Appropriate treatment was commenced. Reports of similar occurrences of synchronous thyroid and parathyroid pathologies are discussed.

Conclusion:

To our knowledge, this is the first reported case of two synchronous thyroid cancers occurring in the context of primary hyperparathyroidism. We strongly recommend a thorough radiological investigation of all patients with primary hyperparathyroidism to prevent missing concurrent thyroid cancers.

Keywords

Thyroid NeoplasmsHyperparathyroidism, PrimaryThyroid Cancer, MedullaryRET Protein, HumanCarcinoma, Papillary
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 6 , June 2014 , pp. 565 - 568
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Machens, A, Dralle, H. Simultaneous medullary and papillary thyroid cancer: A novel entity? Ann Surg Oncol 2012;19:37–44CrossRefGoogle ScholarPubMed
2Behrend, M, von Wasielewski, R, Brabant, G. Simultaneous medullary and papillary microcarcinoma of thyroid in a patient with secondary hyperparathyroidism. Endocr Pathol 2002;13:65–73CrossRefGoogle Scholar
3Onkendi, EO, Richards, ML, Thompson, GB, Farley, DR, Peller, PJ, Grant, CS. Thyroid cancer detection with dual-isotope parathyroid scintigraphy in primary hyperparathyroidism. Ann Surg Oncol 2012;19:1446–52Google Scholar
4Arciero, CA, Shiue, ZS, Gates, JD, Peoples, GE, Dackiw, AP, Tufano, RP et al. Preoperative thyroid ultrasound is indicated in patients undergoing parathyroidectomy for primary hyperparathyroidism. J Cancer 2012;3:1–6Google Scholar
5Pallan, S, Rahman, MO, Khan, AA. Diagnosis and management of primary hyperparathyroidism. BMJ 2012;344:e1013Google Scholar
6Rone, JK, Lane, AG, Grinkemeyer, MD. Papillary thyroid carcinoma, parathyroid adenoma, and unexplained hypercalcitoninemia: an unusual presentation of multiple endocrine neoplasia type 2A? Thyroid 1998;8:781–5CrossRefGoogle ScholarPubMed
7Elisei, R, Romei, C, Cosci, B, Agate, L, Bottici, V, Molinaro, E et al. RET genetic screening in patients with medullary thyroid cancer and their relatives: Experience with 807 individuals at one center. J Clin Endocrinol Metab 2007;92:4725–9CrossRefGoogle ScholarPubMed
8Romei, C, Mariotti, S, Fugazzola, L, Taccaliti, A, Pacini, F, Opocher, G et al. Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes. Eur J Endocrinol 2010;163:301–8CrossRefGoogle ScholarPubMed
9Leitha, T, Staudenherz, A. Concomitant hyperparathyroidism and nonmedullary thyroid cancer, with a review of the literature. Clin Nucl Med 2003;28:113–17CrossRefGoogle ScholarPubMed
10Triggs, SM, Williams, ED. Experimental carcinogenesis in the thyroid follicular and C cells: a comparison of the effect of variation in dietary calcium and of radiation. Acta Endocrinol (Copenh) 1977;85:84–92Google Scholar
11LiVolsi, VA, Feind, CR. Parathyroid adenoma and nonmedullary thyroid carcinoma. Cancer 1976;38:1391–3Google Scholar
12Kim, WG, Gong, G, Kim, EY, Kim, TY, Hong, SJ, Kim, WB et al. Concurrent occurrence of medullary thyroid carcinoma and papillary thyroid carcinoma in the same thyroid should be considered as coincidental. Clin Endocrinol (Oxf) 2010;72:256–63CrossRefGoogle ScholarPubMed
13Biscolla, RP, Ugolini, C, Sculli, M, Bottici, V, Castagna, MG, Romei, C et al. Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behaviour. Thyroid 2004;14:946–52Google Scholar
14Rossi, S, Lugazzola, L, De Pasquale, L, Braidotti, P, Cirello, V, Beck-Peccoz, P et al. Medullary and papillary carcinoma of the thyroid gland occurring as a collision tumour: report of three cases with molecular analysis and review of the literature. Endocr Relat Cancer 2005;12:281–9CrossRefGoogle ScholarPubMed
15Lang, W, Borrusch, H, Bauer, L. Occult carcinomas of the thyroid. Evaluation of 1020 sequential autopsies. Am J Clin Pathol 1988;9:72–6Google Scholar
16Jeong, JS, Kim, HK, Lee, C, Park, S, Park, JH, Kang, SW et al. Coexistence of Chronic Lymphocytic Thyroiditis with Papillary Thyroid Carcinoma: Clinical Manifestation and Prognostic Outcome. J Korean Med Sci 2012;27:883–9CrossRefGoogle ScholarPubMed
17Kebebew, E, Treseler, PA, Ituarte, PH, Clark, OH. Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J Surg 2001;25:632–7CrossRefGoogle ScholarPubMed
18Galera-Davison, M, Fernandez, A, Salguera, M, Martin-Lacave, I, Gonzalez-Campora, R. Simultaneous hyperplasia of follicular and parafollicular cells in experimental hypothyroidism. Lab Invest 1988;58:33AGoogle Scholar
19Boelaert, K. The association between serum TSH concentration and thyroid cancer. Endocr Relat Cancer 2009;16:1065–72CrossRefGoogle ScholarPubMed