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Benefits of pre-labyrinthectomy intratympanic gentamicin: contralateral vestibular responses

Published online by Cambridge University Press:  16 July 2019

N Amiraraghi ,
M Gaggini ,
J A Crowther ,
R Locke ,
W Taylor  and
G Kontorinis
N Amiraraghi
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
M Gaggini
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
J A Crowther
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
R Locke
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
W Taylor
Affiliation:
Department of Neurosurgery, Skull Base Unit, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
G Kontorinis*
Affiliation:
Department of Otolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
*
Author for correspondence: Mr Georgios Kontorinis, Department of Otolaryngology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK E-mail: gkontorinis@gmail.com Fax: +44 1413 478 028
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Abstract

Objective

To determine the impact of pre-operative intratympanic gentamicin injection on the recovery of patients undergoing translabyrinthine resection of vestibular schwannomas.

Methods

This prospective, case–control pilot study included eight patients undergoing surgical labyrinthectomy, divided into two groups: four patients who received pre-operative intratympanic gentamicin and four patients who did not. The post-operative six-canal video head impulse test responses and length of in-patient stay were assessed.

Results

The average length of stay was shorter for patients who received intratympanic gentamicin (6.75 days; range, 6–7 days) than for those who did not (9.5 days; range, 8–11 days) (p = 0.0073). Additionally, the gentamicin group had normal post-operative video head impulse test responses in the contralateral ear, while the non-gentamicin group did not.

Conclusion

Pre-operative intratympanic gentamicin improves the recovery following vestibular schwannoma resection, eliminating, as per the video head impulse test, the impact of labyrinthectomy on the contralateral labyrinth.

Keywords

DizzinessGentamicinLabyrinthVestibular SchwannomaVestibular Function Tests
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 133 , Issue 8 , August 2019 , pp. 668 - 673
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Mr G Kontorinis takes responsibility for the integrity of the content of the paper

Presented orally at the Annual Meeting of the North American Skull Base Society, 16–18 February 2018, San Diego, California, USA.

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