Skip to main content Accesibility Help

Chloroquine ototoxicity—a reversible phenomenon?

  • D. K. Mukherjee (a1)

A BRIEF review of cranio-facial fibro-osseous lesions is given and 15 cases of fibrous dysplasia and ossifying fibroma are presented with clinical, radiological and histomorphological findings. After histological verification of the fibro-osseous nature of the process, 5 lesions were diagnosed on a radiological basis as fibrous dysplasia exhibiting diffuse (blending) margins, while the diagnosis of ossifying fibroma was given to 10 radiologically sharply-demarcated lesions. Both groups of lesions presented the same histomorphological features, although to a varying degree. Spheroidal calcifications, however, were identified in ossifying fibroma only, but not in all of these. Thus, the differential diagnosis of fibrous dysplasia versus ossifying fibroma rests on a radiological criterion after the histopathologist has verified the fibro-osseous nature of a lesion. The observation times varied from 1 ½ to 34 years. Two cases of fibrous dysplasia and 3 cases of ossifying fibroma recurred. In one case of fibrous dysplasia an osteosarcoma developed 33 years after irradiation. Pain was a, common symptom in the present material.

Hide All
Ballantyne, J. C. (1973) ‘Ototoxicity’: In Recent Advances in Otolaryngology: Ed. Ransome, J., Holden, H. and Bull, T. R.Churchill Livingstone, London, Publisher.
Hennebert, D., and Fernandez, C. (1959) Archives of Otolaryngology, 70, 321.
Langenbeck, B. (1965) Textbook of Practical Audiometry; publisher—Edward Arnold, London.
Mukherjee, D. K. and Mukherjee, K. (1978) ‘Ototoxicity of commonly used pharmaceutical preparations’: Nigerial Medical Journal, 10.
Naunton, R. R. and Hart, C. W. (1964) ‘The Ototoxicity of chloroquine phosphate’. Archives of Otolaryngology, 30, 407.
Obiako, M. N. (1978) Sudden deafness and chloroquine injection': personal communication.
Ruedi, L., Furrer, W., Luthy, F., Nager, G. and Tschirren, B. (1952) Laryngoscope, 62, 333.
Scherbel, A. L., Harrison, J. W. and Atdjian, M. (1958) ‘Further observations on use of4-Aminoquinolone compounds in patients with Rheumatoid Arthritis or related diseases’. Clinical Quarterly, 25, 95111.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed