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Choroidal thickness evaluation in paediatric patients with adenotonsillar hypertrophy

  • A Yenigun (a1), A Elbay (a2), A M Hafiz (a1) and O Ozturan (a1)
Abstract Objective:

To investigate choroidal thickness using enhanced-depth imaging optical coherence tomography in paediatric patients with adenotonsillar hypertrophy, with comparison to healthy children, three months after adenotonsillectomy.


The patients were assigned to three groups: an adenotonsillar hypertrophy group, an adenotonsillectomy group and a healthy control group. In all groups, subfoveal, temporal and nasal choroidal thickness measurements were taken.


In the subfoveal, temporal and nasal regions, choroidal tissue was found to be significantly thinner in adenotonsillar hypertrophy children than healthy children (p = 0.012, p = 0.027 and p = 0.020). The subfoveal and temporal choroidal thickness measurements of adenotonsillar hypertrophy group cases were significantly decreased compared to those in the adenotonsillectomy group (p = 0.038 and p = 0.048).


There was a significant association between decreased choroidal thickness and adenotonsillar hypertrophy. Adenotonsillar hypertrophy may play an important role in decreased choroidal thickness.

Corresponding author
Address for correspondence: Dr Alper Yenigun, Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı, Vatan Caddesi, 34093 Fatih, İstanbul Fax: +90 (212) 453 18 70 E-mail:
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1 Redline S, Tishler PV, Schluchter M, Aylor J, Clark K, Graham G. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med 1999;159:1527–32
2 Bower CM, Gungor A. Pediatric obstructive sleep apnea syndrome. Otolaryngol Clin North Am 2000;33:4975
3 Alexiou VG, Salazar-Salvia MS, Jervis PN, Falagas ME. Modern technology-assisted vs conventional tonsillectomy: a meta-analysis of randomized controlled trials. Arch Otolaryngol Head Neck Surg 2011;137:558–70
4 Zengin MO, Oz T, Baysak A, Cinar E, Kucukerdonmez C. Changes in choroidal thickness in patients with obstructive sleep apnea syndrome. Ophthalmic Surg Lasers Imaging Retina 2014;45:298304
5 Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res 2010;29:144–68
6 Wong IY, Koizumi H, Lai WW. Enhanced depth imaging optical coherence tomography. Ophthalmic Surg Lasers Imaging 2011;42:7584
7 Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008;146:496500
8 Fujiwara T, Imamura Y, Margolis R, Slakter JS, Spaide RF. Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes. Am J Ophthalmol 2009;148:445–50
9 Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci 2009;50:3876–80
10 Yeoh J, Rahman W, Chen F, Hooper C, Patel P, Tufail A et al. Choroidal imaging in inherited retinal disease using the technique of enhanced depth imaging optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2010;248:1719–28
11 Spaide RF. Age-related choroidal atrophy. Am J Ophthalmol 2009;147:801–10
12 Xin C, Wang J, Zhang W, Wang L, Peng X. Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS). Eye 2014;28:415–21
13 Kara S, Ozcimen M, Bekci TT, Sakarya Y, Gencer B, Tufan HA et al. Evaluation of choroidal thickness in patients with obstructive sleep apnea/hypopnea syndrome. Arq Bras Oftalmol 2014;77:280–4
14 Karalezli A, Eroglu FC, Kivanc T, Dogan R. Evaluation of choroidal thickness using spectral-domain optical coherence tomography in patients with severe obstructive sleep apnea syndrome: a comparative study. Int J Ophthalmol 2014;7:1030–4
15 Brodsky L, Moore L, Stanievich J. The role of Haemophilus influenzae in the pathogenesis of tonsillar hypertrophy in children. Laryngoscope 1988;98:1055–60
16 Richardson MA. Sore throat, tonsillitis, and adenoiditis. Med Clin North Am 1999;83:7583
17 Yenigun A. The efficacy of tonsillectomy in chronic tonsillitis patients as demonstrated by the neutrophil-to-lymphocyte ratio. J Laryngol Otol 2015;129:386–91
18 Parker NP, Walner DL. Trends in the indications for pediatric tonsillectomy or adenotonsillectomy. Int J Pediatr Otorhinolaryngol 2011;75:282–5
19 Jelic S, Padeletti M, Kawut SM, Higgins C, Canfield SM, Onat D et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation 2008;117:2270–8
20 Maruko I, Iida T, Sugano Y, Ojima A, Sekiryu T. Subfoveal choroidal thickness in fellow eyes of patients with central serous chorioretinopathy. Retina 2011;31:1603–8
21 Nakayama M, Keino H, Okada AA, Watanabe T, Taki W, Inoue M et al. Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. Retina 2012;32:2061–9
22 Delaey C, Van De Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res 2000;32:249–56
23 He M, Han X, Wu H, Huang W. Choroidal thickness changes in obstructive sleep apnea syndrome: a systematic review and meta-analysis. Sleep Breath 2016;20:369–78
24 Chung SE, Kang SW, Lee JH, Kim YT. Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration. Ophthalmology 2011;118:840–5
25 Kubota T, Jonas JB, Naumann GO. Decreased choroidal thickness in eyes with secondary angle closure glaucoma. An aetiological factor for deep retinal changes in glaucoma? Br J Ophthalmol 1993;77:430–2
26 Esmaeelpour M, Považay B, Hermann B, Hofer B, Kajic V, Hale SL et al. Mapping choroidal and retinal thickness variation in type 2 diabetes using three-dimensional 1060-nm optical coherence tomography. Invest Ophthalmol Vis Sci 2011;52:5311–16
27 He M, Huang W. The role of choroidal thickness in diabetic retinopathy and obstructive sleep apnea syndrome. Sleep Breath 2016;20:1009–10
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
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