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Determination of remnant thyroid volume: comparison of ultrasonography, radioactive iodine uptake and serum thyroid-stimulating hormone level

Published online by Cambridge University Press:  03 July 2007

Y Erbil ,
U Barbaros ,
A Salmaslıoglu ,
H Issever ,
M Tukenmez ,
I Adalet ,
A Bozbora ,
S Özarmagan  and
S Tezelman
Y Erbil*
Affiliation:
Department of General Surgery, Medical Faculty, Istanbul University, Turkey
U Barbaros
Affiliation:
Department of General Surgery, Medical Faculty, Istanbul University, Turkey
A Salmaslıoglu
Affiliation:
Department of Radiology, Medical Faculty, Istanbul University, Turkey
H Issever
Affiliation:
Department of Public Health and Medical Faculty, Istanbul University, Turkey
M Tukenmez
Affiliation:
Department of General Surgery, Medical Faculty, Istanbul University, Turkey
I Adalet
Affiliation:
Department of Nuclear Medicine, Medical Faculty, Istanbul University, Turkey
A Bozbora
Affiliation:
Department of General Surgery, Medical Faculty, Istanbul University, Turkey
S Özarmagan
Affiliation:
Department of General Surgery, Medical Faculty, Istanbul University, Turkey
S Tezelman
Affiliation:
Department of General Surgery, Medical Faculty, Istanbul University, Turkey
*
Address for correspondence: Dr Yesim Erbil, Department of General Surgery, Medical Faculty, Istanbul University, Istanbul 34093, Turkey. Fax: 90 212 5341605 E-mail: yerbil2003@yahoo.com
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Abstract

Purpose:

We aimed to evaluate the accuracy of ultrasonography, radioactive iodine uptake and serum thyroid-stimulating hormone level in predicting the volume of remnant thyroid gland.

Methods:

Sixty-six thyroidectomy patients were divided into two groups according to their functional status, i.e. those operated upon for nontoxic multinodular goitre (group one) and those operated upon for hyperthyroidism (group two). Ultrasonography, radioactive iodine uptake and thyroid-stimulating hormone assay were performed in all patients during the first post-operative month. The two groups were subdivided according to the amount of remnant thyroid volume detected on ultrasonography: <2 ml, 2–5 ml and >5 ml.

Results:

The remnant thyroid volume was positively correlated with the radioactive iodine uptake (rs = 0.684, p = 0.0001). The increase in remnant thyroid tissue radioactive iodine uptake was significantly greater in the patients operated upon for hyperthyroidism compared with those operated upon for nontoxic multinodular goitre (p = 0.0001). There was a negative correlation between remnant thyroid volume and post-operative serum thyroid-stimulating hormone level (rs =  −0.865, p = 0.0001) and between remnant thyroid tissue radioactive iodine uptake and post-operative serum thyroid-stimulating hormone level (rs = −0.682, p = 0.0001).

Conclusion:

Ultrasonography is a more accurate measure of remnant thyroid volume than radioactive iodine uptake in patients operated upon for hyperthyroidism, compared with those operated upon for nontoxic multinodular goitre.

Keywords

Thyroid GlandThyroid NeoplasmsThyroidectomyUltrasound
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 122 , Issue 6 , June 2008 , pp. 615 - 622
Copyright
Copyright © JLO (1984) Limited 2007

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References

1 Nakhjavani, M, Gharib, H. Diffuse nontoxic and multinodular goitre. Curr Ther Endocrinol Metab 1997;6:109–12Google Scholar
2 Hegedus, L, Bonnema, SJ, Bennedbaek, FN. Management of simple nodular goitre: current status and future perspectives. Endocr Rev 2003;24:102–32CrossRefGoogle ScholarPubMed
3 DeGroot, LJ. Treatment of multinodular goitre by surgery. J Endocrinol Invest 2001;24:820–2CrossRefGoogle ScholarPubMed
4 Diehl, LA, Garcia, V, Bonnema, SJ, Hegedus, L, Albino, CC, Graf, H. Latin American Thyroid Society. Management of the nontoxic multinodular goitre in Latin America: comparison with North America and Europe, an electronic survey. J Clin Endocrinol Metab 2005;90:117–23CrossRefGoogle ScholarPubMed
5 Bonnema, SJ, Bennedbaek, FN, Ladenson, PW, Hegedus, L. Management of the nontoxic multinodular goitre: a North American survey. J Clin Endocrinol Metab 2002;87:112–17CrossRefGoogle ScholarPubMed
6 Giles, Y, Boztepe, H, Terzioglu, T, Tezelman, S. The advantage of total thyroidectomy to avoid reoperation for incidental thyroid cancer in multinodular goitre. Arch Surg 2004;139:179–82CrossRefGoogle Scholar
7 Bellantone, R, Lombardi, CP, Bossola, M, Boscherini, M, De Crea, C, Alesina, P et al. Total thyroidectomy for management of benign thyroid disease: review of 526 cases. World J Surg 2002;26:1468–71CrossRefGoogle ScholarPubMed
8 Mishra, A, Agarwal, A, Agarwal, G, Mishra, SK. Total thyroidectomy for benign thyroid disorders in an endemic region. World J Surg 2001;25:307–10CrossRefGoogle Scholar
9 Bron, LP, O'Brien, CJ. Total thyroidectomy for clinically benign disease of the thyroid gland. Br J Surg 2004;91:569–74CrossRefGoogle ScholarPubMed
10 Delbridge, L, Guinea, AI, Reeve, TS. Total thyroidectomy for bilateral benign multinodular goitre: effect of changing practice. Arch Surg 1999;134:1389–93CrossRefGoogle ScholarPubMed
11 Mazzaferri, EL, Kloos, RT. Clinical review 128: Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab 2001;86:1447–63CrossRefGoogle ScholarPubMed
12 Ko, HM, Jhu, IK, Yang, SH, Lee, JH, Nam, JH, Juhng, SW et al. Clinicopathologic analysis of fine needle aspiration cytology of the thyroid. A review of 1,613 cases and correlation with histopathologic diagnoses. Acta Cytol 2003;47:727–32CrossRefGoogle Scholar
13 Belfiore, A, La Rosa, GL. Fine-needle aspiration biopsy of the thyroid. Endocrinol Metab Clin North Am 2001;30:361–400CrossRefGoogle ScholarPubMed
14 Sakorafas, GH, Giotakis, J, Stafyla, V. Papillary thyroid microcarcinoma: a surgical perspective. Cancer Treat Rev 2005;31:423–38CrossRefGoogle ScholarPubMed
15 Menzel, C, Grünwald, F, Biersack, HJ. Monitoring of low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 2003;88:1433–41CrossRefGoogle ScholarPubMed
16 Pearce, EN, Braverman, LE. Papillary thyroid microcarcinoma outcomes and implications for treatment. J Clin Endocrinol Metab 2004;89:3710–12CrossRefGoogle ScholarPubMed
17 Pellegriti, G, Scollo, C, Lumera, G, Regalbuto, C, Vigneri, R, Belfiore, A. Clinical behavior and outcome of papillary thyroid cancers smaller than 1.5 cm in diameter: study of cases. J Clin Endocrinol Metab 2004;89:3713–20CrossRefGoogle Scholar
18 Haugen, BR. Patients with differentiated thyroid carcinoma benefit from radioiodine remnant ablation. J Clin Endocrinol Metab 2004;89:3665–7CrossRefGoogle ScholarPubMed
19 Hegedus, L. Thyroid ultrasound. Endocrinol Metab Clin North Am 2001;30:339–60CrossRefGoogle ScholarPubMed
20 Szebeni, A, Beleznay, E. New, simple method for thyroid volume determination by ultrasonography. J Clin Ultrasound 1992;20:329–37CrossRefGoogle ScholarPubMed
21 Shabana, W, Peeters, E, Verbeek, P, Osteaux, MM. Reducing inter-observer variation in thyroid volume calculation using a new formula and technique. Eur J Ultrasound 2003;16:207–10CrossRefGoogle ScholarPubMed
22 Nygaard, B, Nygaard, T, Court-Payen, M, Jensen, LI, Soe-Jensen, P, Gerhard Nielsen, K et al. Thyroid volume measured by ultrasonography and CT. Acta Radiol 2002;43:269–74CrossRefGoogle ScholarPubMed
23 Pappalardo, G, Guadalaxara, A, Frattaroli, FM, Illomei, G, Falaschi, P. Total compared with subtotal thyroidectomy in benign nodular disease: personal series and review of published reports. Eur J Surg 1998;164:501–6CrossRefGoogle ScholarPubMed
24 Bergamaschi, R, Becouarn, G, Ronceray, J, Arnaud, JP. Morbidity of thyroid surgery. Am J Surg 1998;176:71–5CrossRefGoogle ScholarPubMed
25 Bhattacharyya, N, Fried, MP. Assessment of the morbidity and complications of total thyroidectomy. Arch Otolaryngol Head Neck Surg 2002;128:389–92CrossRefGoogle ScholarPubMed
26 Thomusch, O, Machens, A, Sekulla, C, Ukkat, J, Lippert, H, Gastinger, I et al. Multivariate analysis of risk factors for postoperative complications in benign goitre surgery: prospective multicenter study in Germany. World J Surg 2000;24:1335–41CrossRefGoogle ScholarPubMed
27 Meier, DA, Kaplan, MM. Radioiodine uptake and thyroid scintiscanning. Endocrinol Metab Clin North Am 2001;30:291–313CrossRefGoogle ScholarPubMed
28 Pacini, F, Schlumberger, M, Harmer, C, Berg, GG, Cohen, O, Duntas, L et al. Post-surgical use of radioiodine (131I) in patients with papillary and follicular thyroid cancer and the issue of remnant ablation: a consensus report. Eur J Endocrinol 2005;153:651–9CrossRefGoogle ScholarPubMed
29 Sawka, AM, Thephamongkhol, K, Brouwers, M, Thabane, L, Browman, G, Gerstein, HC. Clinical review 170: A systematic review and meta analysis of the effectiveness of radioactive iodine remnant ablation for well-differentiated thyroid cancer. J Clin Endocrinol Metab 2004;89:3668–76CrossRefGoogle ScholarPubMed
30 Mazzaferri, E. A randomized trial of remnant ablation – in search of an impossible dream? J Clin Endocrinol Metab 2004;89:3662–4CrossRefGoogle ScholarPubMed
31 Rosario, PW, Maia, FF, Cardoso, LD, Barroso, A, Rezende, L, Padrao, EL et al. Correlation between cervical uptake and results of postsurgical radioiodine ablation in patients with thyroid carcinoma. Clin Nucl Med 2004;29:358–61CrossRefGoogle ScholarPubMed
32 Cailleux, AF, Baudin, E, Travagli, JP, Ricard, M, Schlumberger, M. Is diagnostic iodine-131 scanning useful after total thyroid ablation for differentiated thyroid cancer? J Clin Endocrinol Metab 2000;85:175–8CrossRefGoogle ScholarPubMed
33 Leung, SF, Law, MW, Ho, SK. Efficacy of low-dose iodine-131 ablation of postoperative thyroid remnants: a study of 69 cases. Br J Radiol 1992;65:905–9CrossRefGoogle ScholarPubMed
34 Beierwaltes, WH, Rabbani, R, Dmuchowski, C, Lloyd, RV, Eyre, P, Mallette, S. An analysis of “ablation of thyroid remnants” with I-131 in 511 patients from 1947–1984: experience at University of Michigan. J Nucl Med 1984;25:1287–93Google ScholarPubMed
35 Logue, JP, Tsang, RW, Brierley, JD, Simpson, WJ. Radioiodine ablation of residual tissue in thyroid cancer: relationship between administered activity, neck uptake and outcome. Br J Radiol 1994;67:1127–31CrossRefGoogle ScholarPubMed
36 Snyder, J, Gorman, C, Scanlon, P. Thyroid remnant ablation: questionable pursuit of an ill-defined goal. J Nucl Med 1983;24:659–65Google ScholarPubMed